Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John M. A. Grime"'
Autor:
John M. A. Grime, James F. Dama, Barbie K. Ganser-Pornillos, Cora L. Woodward, Grant J. Jensen, Mark Yeager, Gregory A. Voth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Significant morphological changes occur during the conversion of the immature HIV virion into a mature infectious form. Here the authors use coarse-grained molecular dynamics simulations to model HIV-1 capsid self-assembly and disassembly events that
Externí odkaz:
https://doaj.org/article/cb54a296583545b2ab2085fab3f7c41c
Publikováno v:
Journal of the American Chemical Society
The early and late stages of human immunodeficiency virus (HIV) replication are orchestrated by the capsid (CA) protein, which self-assembles into a conical protein shell during viral maturation. Small molecule drugs known as capsid inhibitors (CIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99c882ad903f029bcd41bd930ba0f17
https://pubmed.ncbi.nlm.nih.gov/31244184
https://pubmed.ncbi.nlm.nih.gov/31244184
The early and late stages of human immunodeficiency virus (HIV) replication are orchestrated by the capsid (CA) protein, which self-assembles into a conical protein shell during viral maturation. Small molecule drugs known as capsid inhibitors (CIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9087f46e5ba20403e4d479461c753306
https://doi.org/10.1101/565515
https://doi.org/10.1101/565515
The influenza A matrix 2 (M2) transmembrane protein facilitates virion release from the infected host cell. In particular, M2 plays a role in the induction of membrane curvature and/or in the scission process whereby the envelope is cut upon virion r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f872a011e946b19a90882c1b141120bd
https://doi.org/10.1101/291120
https://doi.org/10.1101/291120
Publikováno v:
Biophysical Journal. 116:61a-62a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed9a7b1bc0d03670fccdb66865712dd1
https://doi.org/10.1016/j.bpj.2018.11.378
https://doi.org/10.1016/j.bpj.2018.11.378
Autor:
Antony K. Chen, Alexander J. Pak, Aleksander E. P. Durumeric, Prabuddha Sengupta, John M. A. Grime, John A. G. Briggs, Anand Srivastava, Gregory A. Voth, Mark Yeager, Jennifer Lippincott-Schwartz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(47)
The packaging and budding of Gag polyprotein and viral RNA is a critical step in the HIV-1 life cycle. High-resolution structures of the Gag polyprotein have revealed that the capsid (CA) and spacer peptide 1 (SP1) domains contain important interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2659ad51ce000238a6d1900851d62c8c
https://pubmed.ncbi.nlm.nih.gov/29114055
https://pubmed.ncbi.nlm.nih.gov/29114055
Autor:
John M. A. Grime, Antony K. Chen, John A. G. Briggs, Alexander J. Pak, Prabuddha Sengupta, Jennifer Lippincott-Schwartz, Anand Srivastava, Mark Yeager, Gregory A. Voth, Aleksander E. P. Durumeric
The packaging and budding of Gag polyprotein and viral ribonucleic acid (RNA) is a critical step in the human immunodeficiency virus-1 (HIV-1) lifecycle. High-resolution structures of the Gag polyprotein have revealed that the capsid (CA) and spacer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d7038e9f5f18d72395419d2a8ff3e6
https://doi.org/10.1101/163295
https://doi.org/10.1101/163295
Publikováno v:
Journal of Computational Physics. 238:97-105
We use Dissipative Particle Dynamics simulations, combined with parallel tempering and umbrella sampling, to investigate the potential of mean force between model transmembrane peptides in the various phases of a lipid bilayer, including the low-temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b3c9bdd2120749202e13a54f52b32f
https://doi.org/10.1016/j.jcp.2012.12.014
https://doi.org/10.1016/j.jcp.2012.12.014
Autor:
Barbie K. Ganser-Pornillos, John M. A. Grime, Grant J. Jensen, Mark Yeager, Gregory A. Voth, James F. Dama, Cora L. Woodward
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c59eb1dbd4b56d00752a44a9bc23ad
https://resolver.caltech.edu/CaltechAUTHORS:20160516-083514191
https://resolver.caltech.edu/CaltechAUTHORS:20160516-083514191
Autor:
John M. A. Grime, Malek O. Khan
Publikováno v:
Journal of chemical theory and computation. 6(10)
A system of counterions between charged surfaces is investigated, with the surfaces represented by uniform charged planes and three different arrangements of discrete surface charges - an equispaced grid and two different clustered arrangements. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdf8e50e0805f1e31451a37e0185ed2
https://pubmed.ncbi.nlm.nih.gov/26616782
https://pubmed.ncbi.nlm.nih.gov/26616782