Zobrazeno 1 - 10
of 111
pro vyhledávání: '"John M. Wells"'
Publikováno v:
Ethics & Human Research
With the rapid spread of SARS‐CoV2 has come a rapid proliferation of clinical research studies, resulting in considerable strain on research ethics committees (RECS), which need to review study proposals. RECs are pressured to move through the revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fceb3678eab621d265ef0fd7555a73f
https://doi.org/10.1002/eahr.500104
https://doi.org/10.1002/eahr.500104
Autor:
Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J Morin, John M Wells, Eugene B Hanlon, Weiming Xia
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163072 (2016)
The testing of candidate drugs to slow progression of Alzheimer's disease (AD) requires clinical trials that are lengthy and expensive. Efforts to model the biochemical milieu of the AD brain may be greatly facilitated by combining two cutting edge t
Externí odkaz:
https://doaj.org/article/a859efebb5544b559c55c1424ad10da8
Autor:
Christopher P. Sullivan, Anthony G. Jay, Edward C. Stack, Maria Pakaluk, Erin Wadlinger, Richard E. Fine, John M. Wells, Peter J. Morin
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 2, Pp 338-345 (2011)
Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is foun
Externí odkaz:
https://doaj.org/article/f8abd9a832864fe0913fb4fd225707f0
Autor:
Themistocles L. Assimes, P. S. Sriram, Qin Hui, Stephen Mastorides, Zuhair Ballas, Yan V. Sun, Hua Tang, Marijana Vujkovic, Ronald G Washburn, Samuel M. Aguayo, Jennifer Moser, Gwenevere Anderson, Mary A. Whooley, Sumitra Muralidhar, Agnes Wallbom, Adriana M. Hung, Xuan-Mai T. Nguyen, Huaying Fang, Jennifer Greco, Rachel B. Ramoni, Amparo Gutierrez, Saiju Pyarajan, Stuart R. Warren, Rob Striker, Pran Iruvanti, Mark B. Hamner, Scott L. DuVall, Elizabeth R. Hauser, Christopher J. O'Donnell, Donald E. Humphries, Jon B. Klein, Nora R. Ratcliffe, John M. Wells, Maureen Murdoch, Gerardo Villareal, Laurence Kaminsky, Peter W. F. Wilson, Mary E. Oehlert, Mary Brophy, Stacey B. Whitbourne, Louis J. Dell’Italia, Grant D. Huang, Ronald Fernando, Dean P. Argyres, Jie Huang, Hongyu Zhao, Scott Kinlay, Kelly Cho, Jeff Whittle, Scott M. Damrauer, Jacqueline Honerlaw, Sunil K. Ahuja, Laurence Meyer, Brooks Robey, John B. Harley, Gretchen Gibson, John Concato, Rachel McArdle, David Cohen, Krisann K. Oursler, Robin A. Hurley, Sujata Bhushan, Salvador Gutierrez, D Jhala, John J. Callaghan, Ron B. Schifman, Nhan Do, Junzhe Xu, Jim Breeling, Jessica V. Brewer, Elif Sonel, Kyong-Mi Chang, Peter W.F. Wilson, Brady Stephens, Shahpoor Shayan, Philip S. Tsao, Joseph Fayad, Michael Godschalk, Jack H. Lichy, Scott Sherman, Shing Shing Yeh, Alan Swann, Michael Rauchman, Samir Gupta, Satish C. Sharma, Edward Boyko, J. Michael Gaziano, Julie Lynch, Timothy R. Morgan, Jean C. Beckham, Todd Stapley, Malcolm Buford, Richard J. Servatius, Hermes Florez, Kathlyn Sue Haddock
Publikováno v:
The American Journal of Human Genetics. 105:763-772
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic factors influencing complex traits related to health and disease among minority populations. At the same time, the genetic diversity in these cohorts presents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e8abe2f5325384907eaed00bf56b85
https://doi.org/10.1016/j.ajhg.2019.08.012
https://doi.org/10.1016/j.ajhg.2019.08.012
Publikováno v:
The New phytologistReferences. 136(4)
SUMMARY Development of mycelial cord systems of Phanerochaete velutina (DC.: Pers.) Parmasto from 4-cm3 inocula on a nutrient-depleted non-sterile soil was studied in laboratory microcosms using image analysis techniques. Cord systems were “baited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8299c6d25ab938055a1802e528153c47
https://pubmed.ncbi.nlm.nih.gov/33863108
https://pubmed.ncbi.nlm.nih.gov/33863108
Autor:
John M. Wells, J. E. Butterfield
Publikováno v:
Plant disease. 81(8)
Wash water from 66% of 401 samples of fresh fruits and vegetables collected in the marketplace and affected by bacterial soft rot were positive for suspected strains of Salmonella, i.e., black, hydrogen sulfide-positive colonies on Salmonella-Shigell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3232cdb6d3d2d107a288be6e19097feb
https://pubmed.ncbi.nlm.nih.gov/30866372
https://pubmed.ncbi.nlm.nih.gov/30866372
Publikováno v:
Plant disease. 82(5)
EDTA and the antibiotic nisin, in combination with heat, were tested for inhibition of growth of six pectolytic, soft-rotting bacteria in 80% trypticase soy broth (TSB). Fifty percent reduction of growth by EDTA at 25°C in TSB occurred at 3.24 mM fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643d926a3eaa78f24109d594c7b5ad49
https://pubmed.ncbi.nlm.nih.gov/30856977
https://pubmed.ncbi.nlm.nih.gov/30856977
Autor:
Pran Iruvanti, Gwenevere Anderson, Mary A. Whooley, Jacqueline Honerlaw, Saiju Pyarajan, Jennifer Moser, Yichi Zhang, Michael Rauchman, Nhan Do, Junzhe Xu, Mark B. Hamner, Michael Gaziano, David M. Cohen, Yan V. Sun, Kyong-Mi Chang, Mary Brophy, Krisann K. Oursler, J. Michael Gaziano, Christopher J. O'Donnell, Jie Huang, Yuk Lam Ho, Elizabeth R. Hauser, John B. Harley, Laurence Kaminsky, Elif Sonel, Hermes Florez, Jon B. Klein, Malcolm Buford, Petra Schubert, Jennifer Greco, Robin A. Hurley, Gerardo Villareal, Mary E. Oehlert, Samuel M. Aguayo, Jiehuan Sun, Timothy R. Morgan, Hongyu Zhao, Shahpoor Shayan, Jeff Whittle, Rob Striker, Samir Gupta, Kathlyn Sue Haddock, Jean C. Beckham, John Concato, Agnes Wallbom, Grant D. Huang, Richard J. Servatius, Tianrun Cai, Dean P. Argyres, Kelly Cho, Xuan-Mai T. Nguyen, Yuri Ahuja, Maureen Murdoch, Peter W.F. Wilson, Philip S. Tsao, Tianxi Cai, Gretchen Gibson, Joseph Fayad, Amparo Gutierrez, Ron B. Schifman, Jessica V. Brewer, Lauren Costa, Zuhair Ballas, Adriana M. Hung, Katherine P. Liao, Donald E. Humphries, Louis J. Dell’Italia, Todd Stapley, D Jhala, Sunil K. Ahuja, Brooks Robey, Ronald Fernando, Scott Kinlay, Sumitra Muralidhar, Laurence Meyer, P. S. Sriram, Sujata Bhushan, David R. Gagnon, Jim Breeling, Jack H. Lichy, Scott Sherman, Salvador Gutierrez, Brady Stephens, Scott M. Damrauer, Stacey B. Whitbourne, Chuan Hong, Shing Shing Yeh, Rachel Ramoni, Stuart R. Warren, Rachel McArdle, Michael Godschalk, John J. Callaghan, Stephen Mastorides, Ronald G Washburn, Satish C. Sharma, Edward Boyko, Nicholas Link, Alan Swann, Nora R. Ratcliffe, John M. Wells
IMPORTANCE: Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9f3e537da4240761913b8c83faf02c
https://europepmc.org/articles/PMC6233652/
https://europepmc.org/articles/PMC6233652/
Publikováno v:
Stem Cell Research, Vol 15, Iss 2, Pp 325-327 (2015)
Peripheral blood mononuclear cells (PBMC) were donated by a patient with clinically diagnosed frontotemporal dementia (FTD). Induced pluripotent stem cells (iPSCs) were developed using integration-free CytoTune-iPS Sendai Reprogramming factors which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2671bdb46b545a488c7bf0a286c66a3
https://doi.org/10.1016/j.scr.2015.07.004
https://doi.org/10.1016/j.scr.2015.07.004
Autor:
John M. Wells, Anish Kanesa-Thasan, Rosemary Elliott-Bryant, Ann C. McKee, Christopher P. Sullivan, Peter J. Morin, Richard E. Fine
Publikováno v:
Advances in Alzheimer's Disease. :126-131
Wnt signaling has been implicated in Alzheimer’s disease (AD) pathogenesis, but no studies have described Wnt signaling in aging brain. Phosphorylation of the Wnt coreceptor, low-density lipoprotein receptor-related protein 6 (Lrp6), is a sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a1fb6552ea39da3e69c59a56f3c588
https://doi.org/10.4236/aad.2013.24017
https://doi.org/10.4236/aad.2013.24017