Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John M. Lehrach"'
Autor:
Douglas S. Auld, James R. Beasley, David A. Dunn, Susan M. Parlato, Tiffany L. Walker, John M. Lehrach
Publikováno v:
ASSAY and Drug Development Technologies. 1:455-459
IMAP is a non-separation-based, antibody-independent, FP assay that can be applied to many types of protein kinases and phosphatases. This technology is currently being used in many high-throughput screening campaigns throughout the industry. In this
Autor:
Marc-Raleigh Brescia, Douglas S. Auld, Laura L. Rokosz, John M. Lehrach, Tara M. Stauffer, Ian Henderson, Maria L. Webb, Andrew G. Cole
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(5)
The discovery and evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin (IP) receptor antagonists is described. Analogs disclosed showed high affinity for the IP receptor in human platelet membranes with IC50 values of 0.05–0.50 μ
Publikováno v:
Assay and drug development technologies. 1(1 Pt 2)
A screen of a GPCR against Pharmacopeia's combinatorial libraries was performed using 1,536-well plates in a 1.5-microl assay volume with an LSI that was specially modified to enable detection at these volumes. The screen encompassed approximately 4
Autor:
James R. Beasley, David A. Dunn, Tiffany L. Walker, Susan M. Parlato, John M. Lehrach, Douglas S. Auld
Publikováno v:
Assay & Drug Development Technologies; Jun2003, Vol. 1 Issue 3, p455-459, 5p