Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John M Sowerby"'
Autor:
Lyra O Randzavola, Paige M Mortimer, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio XC Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Publikováno v:
eLife, Vol 11 (2022)
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, chronic granulomatous dise
Externí odkaz:
https://doaj.org/article/1b48b81ab31e44d4a2884318ac761009
Autor:
Julia Körholz, Anastasia Gabrielyan, John M. Sowerby, Felix Boschann, Lan-Sun Chen, Diana Paul, David Brandt, Janina Kleymann, Martin Kolditz, Nicole Toepfner, Ralf Knöfler, Eva-Maria Jacobsen, Christine Wolf, Karsten Conrad, Nadja Röber, Min Ae Lee-Kirsch, Kenneth G. C. Smith, Stefan Mundlos, Reinhard Berner, Alexander H. Dalpke, Catharina Schuetz, William Rae
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundInborn errors of immunity (IEI) present with a large phenotypic spectrum of disease, which can pose diagnostic and therapeutic challenges. Suppressor of cytokine signaling 1 (SOCS1) is a key negative regulator of cytokine signaling, and has
Externí odkaz:
https://doaj.org/article/157591a72b194f6cb40a244fa421e25e
Autor:
Marion Espéli, Rachael Bashford-Rogers, John M. Sowerby, Nagham Alouche, Limy Wong, Alice E. Denton, Michelle A. Linterman, Kenneth G. C. Smith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The inhibitory receptor, FcγRIIb, is reported to limit autoimmune B cell response. Here the authors show that FcγRIIb has a dual role in both human and mouse, with reduced FcγRIIb expression or function associated with enhanced pre-immune B cell t
Externí odkaz:
https://doaj.org/article/79eaab1ad06c4833bed4609c3c0f95a6
Autor:
Amélie Bonaud, Simon Clare, Valeria Bisio, John M. Sowerby, Shugang Yao, Hanne Ostergaard, Karl Balabanian, Kenneth G. C. Smith, Marion Espéli
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The generation of a potent humoral immune response by B cells relies on the integration of signals induced by the B cell receptor, toll-like receptors and both negative and positive co-receptors. Several reports also suggest that integrin signaling p
Externí odkaz:
https://doaj.org/article/f2a5a03a38854997b6ab77d7411f784f
Autor:
Paige M Mortimer, Lyra O Randzavola, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio XC Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed7b8a23462d0bf93707f8ec4f553fd
https://doi.org/10.7554/elife.76387.sa2
https://doi.org/10.7554/elife.76387.sa2
Autor:
William, Rae, John M, Sowerby, Dorit, Verhoeven, Mariam, Youssef, Prasanti, Kotagiri, Natalia, Savinykh, Eve L, Coomber, Alexis, Boneparth, Angela, Chan, Chun, Gong, Machiel H, Jansen, Romy, du Long, Giorgia, Santilli, Ilenia, Simeoni, Jonathan, Stephens, Kejia, Wu, Marta, Zinicola, Hana Lango, Allen, Helen, Baxendale, Dinakantha, Kumararatne, Effrossyni, Gkrania-Klotsas, Selma C, Scheffler Mendoza, Marco Antonio, Yamazaki-Nakashimada, Laura Berrón, Ruiz, Cesar Mauricio, Rojas-Maruri, Saul O, Lugo Reyes, Paul A, Lyons, Anthony P, Williams, Daniel J, Hodson, Gail A, Bishop, Adrian J, Thrasher, David C, Thomas, Michael P, Murphy, Timothy J, Vyse, Joshua D, Milner, Taco W, Kuijpers, Kenneth G C, Smith
Publikováno v:
Science immunology. 7(74)
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a central regulator of immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human immunity is not defined. Here, in five unrelated families, we describe an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e24d9e414ab0c7f3318dd753ec84764
https://pubmed.ncbi.nlm.nih.gov/35960817
https://pubmed.ncbi.nlm.nih.gov/35960817
Autor:
Limy Wong, Kenneth G. C. Smith, John M. Sowerby, Rachael Bashford-Rogers, Nagham Alouche, Alice E. Denton, Michelle A. Linterman, Marion Espéli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93bed5518849917602406805d518290
http://link.springer.com/article/10.1038/s41467-019-09434-0
http://link.springer.com/article/10.1038/s41467-019-09434-0
Autor:
Paul A. Lyons, Alexander Hatton, James Lee, John M. Sowerby, Tim F. Rayner, Miles Parkes, Eoin F. McKinney, Hannah M. Rickman, Edward J. Carr, Kenneth G. C. Smith, Huzefa Ratlamwala, Francesca Bredin
Publikováno v:
Journal of Clinical Investigation. 121:4170-4179
Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients. Identification of reliable prognostic biomarkers would enable tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793dfc400bfa1796ab8f1cdd8aeffdb5
https://doi.org/10.1172/jci59255
https://doi.org/10.1172/jci59255
Autor:
Daniel P O'Brien, Allen C. Cheng, Peter Callan, Margaret J. Henry, Anthony McDonald, Ian Holten, John M Sowerby, Mike Birrell, Paul D R Johnson, Andrew J. Hughes, Eugene Athan
Publikováno v:
Medical Journal of Australia. 186:58-61
Objective: To describe the effect of antibiotics on outcomes of treatment for Buruli or Bairnsdale ulcer (BU) in patients on the Bellarine Peninsula in south-eastern Australia. Design: Observational, non-randomised study with data collected prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a956c5d166c68bf3ede151ef8ed5189
https://doi.org/10.5694/j.1326-5377.2007.tb00800.x
https://doi.org/10.5694/j.1326-5377.2007.tb00800.x
Autor:
Katherine Harcourt, Jyoti S. Choudhary, David J. Adams, Ananth Prakash, Daniel M. L. Storisteanu, Gordon Dougan, David Goulding, Shaun M. Flint, Marion Espéli, Kim Hoenderdos, James Lee, Paul A. Lyons, Leanne Kane, Edwin R. Chilvers, Yagnesh Umrania, Kenneth G. C. Smith, Simon Clare, Robin Antrobus, David C. Thomas, Jatinder K. Juss, Louise van der Weyden, Mercedes Pardo, Alex Bateman, Subhankar Mukhopadhyay, Alison M. Condliffe, John M. Sowerby
Publikováno v:
The Lancet. 387:S12
Background Reactive oxygen species (ROS), generated via the phagocyte NADPH oxidase cytochrome b558, are essential for effective immune responses to common and serious pathogens. The phagocyte NADPH oxidase is a multisubunit protein complex and defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691d779bf5cee0e7ce12999b8b4e4776
https://doi.org/10.1016/s0140-6736(16)00399-8
https://doi.org/10.1016/s0140-6736(16)00399-8