Zobrazeno 1 - 10
of 112
pro vyhledávání: '"John M Ong'echa"'
Autor:
Sean V Connelly, Nicholas F Brazeau, Mwinyi Msellem, Billy E Ngasala, Ozkan Aydemir, Varun Goel, Karamoko Niaré, David J Giesbrecht, Zachary R Popkin-Hall, Chris Hennelly, Zackary Park, Ann M Moormann, John M Ong'echa, Robert Verity, Safia Mohammed, Shija J Shija, Lwidiko E Mhamilawa, Ulrika Morris, Andreas Mårtensson, Jessica T Lin, Anders Björkman, Jonathan J Juliano, Jeffrey A Bailey
Publikováno v:
eLife, Vol 12 (2024)
Background: The Zanzibar archipelago of Tanzania has become a low-transmission area for Plasmodium falciparum. Despite being considered an area of pre-elimination for years, achieving elimination has been difficult, likely due to a combination of imp
Externí odkaz:
https://doaj.org/article/6feb7f41f1cd4136b8f33a29805e4a19
Autor:
Lily E. Kisia, Qiuying Cheng, Evans Raballah, Elly O. Munde, Benjamin H. McMahon, Nick W. Hengartner, John M. Ong’echa, Kiprotich Chelimo, Christophe G. Lambert, Collins Ouma, Prakasha Kempaiah, Douglas J. Perkins, Kristan A. Schneider, Samuel B. Anyona
Publikováno v:
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-15 (2022)
Abstract Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte–macrophage colony-
Externí odkaz:
https://doaj.org/article/9181a3a765424ab5950663800c7efad4
Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma
Autor:
Beatrice M. Muriuki, Catherine S. Forconi, Erastus K. Kirwa, Titus K. Maina, Bonface O. Ariera, Jeffrey A. Bailey, Anita Ghansah, Ann M. Moormann, John M. Ong’echa
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Endemic Burkitt lymphoma (eBL) is a fast-growing germinal center B cell lymphoma, affecting 5–10 per 100,000 children annually, in the equatorial belt of Africa. We hypothesize that co-infections with Plasmodium falciparum (Pf) malaria and Epstein-
Externí odkaz:
https://doaj.org/article/bbd6fd04cb4e43f8a84fda999cea8ab6
Autor:
Beatrice M. Muriuki, Catherine S. Forconi, Peter O. Oluoch, Jeffrey A. Bailey, Anita Ghansah, Ann M. Moormann, John M. Ong’echa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Endemic Burkitt lymphoma (eBL) is an aggressive pediatric B cell lymphoma, common in Equatorial Africa. Co-infections with Epstein-Barr virus (EBV) and Plasmodium falciparum, coupled with c-myc translocation are involved in eBL etiology. Inf
Externí odkaz:
https://doaj.org/article/c8bb22471a264e9294c72f6d71cd58d1
Autor:
Peter O. Oluoch, Catherine S. Forconi, Cliff I. Oduor, Dominic A. Ritacco, Hoseah M. Akala, Jeffrey A. Bailey, Jonathan J. Juliano, John M. Ong’echa, Christian Münz, Ann M. Moormann
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6711 (2023)
The seroprevalence of Kaposi sarcoma-associated herpesvirus (KSHV) and the incidence of endemic Kaposi sarcoma (KS) overlap with regions of malaria endemicity in sub-Saharan Africa. Multiple studies have shown an increased risk of KSHV seroconversion
Externí odkaz:
https://doaj.org/article/130e5eebd8bd491d88575eaaaf980f41
Autor:
Nicole Caduff, Donal McHugh, Lisa Rieble, Catherine S. Forconi, John M. Ong’echa, Peter O. Oluoch, Ana Raykova, Anita Murer, Michelle Böni, Lara Zuppiger, Thomas F. Schulz, David J. Blackbourn, Obinna Chijioke, Ann M. Moormann, Christian Münz
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109056- (2021)
Summary: Herpesvirus infections shape the human natural killer (NK) cell compartment. While Epstein-Barr virus (EBV) expands immature NKG2A+ NK cells, human cytomegalovirus (CMV) drives accumulation of adaptive NKG2C+ NK cells. Kaposi sarcoma-associa
Externí odkaz:
https://doaj.org/article/8daa87608142474f9b3ea06d42a3614a
Autor:
Lily E. Kisia, Prakasha Kempaiah, Samuel B. Anyona, Elly O. Munde, Angela O. Achieng, John M. Ong’echa, Christophe G. Lambert, Kiprotich Chelimo, Collins Ouma, Douglas J. Perkins, Evans Raballah
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic feature of SMA, are
Externí odkaz:
https://doaj.org/article/d64936deb1244e07876c59d122a1102c
Autor:
Angela O. Achieng, Nicolas W. Hengartner, Evans Raballah, Qiuying Cheng, Samuel B. Anyona, Nick Lauve, Bernard Guyah, Ivy Foo-Hurwitz, John M. Ong'echa, Benjamin H. McMahon, Collins Ouma, Christophe G. Lambert, Douglas J. Perkins
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 290-302 (2019)
Background: Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods: To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome profiling was performed i
Externí odkaz:
https://doaj.org/article/227c31d2ca5f4169af92c5fbcd96ccb6
Autor:
Angela O. Achieng, Bernard Guyah, Qiuying Cheng, John M. Ong'echa, Collins Ouma, Christophe G. Lambert, Douglas J. Perkins
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 278-289 (2019)
Background: Leukocyte-associated immunoglobulin like receptor-1 (LAIR1) is a transmembrane inhibitory receptor that influences susceptibility to a myriad of inflammatory diseases. Our recent investigations of severe malarial anaemia (SMA) pathogenesi
Externí odkaz:
https://doaj.org/article/621f58e1646d467c86e5748e64d78ce2
Autor:
Catherine S. Forconi, Cliff I. Oduor, Peter O. Oluoch, John M. Ong'echa, Christian Münz, Jeffrey A. Bailey, Ann M. Moormann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Natural Killer (NK) cells play an essential role in antiviral and anti-tumoral immune responses. In peripheral blood, NK cells are commonly classified into two major subsets: CD56brightCD16neg and CD56dimCD16pos despite the characterization of a CD56
Externí odkaz:
https://doaj.org/article/ac2084d03d0f456981037cfc4d973f89