Zobrazeno 1 - 10
of 247
pro vyhledávání: '"John M Nicholls"'
Autor:
Yaqing Jiao, Cindy S. W. Tong, Lingyun Zhao, Yilin Zhang, John M. Nicholls, Timothy H. Rainer
Publikováno v:
Laboratory Animal Research, Vol 40, Iss 1, Pp 1-7 (2024)
Abstract Community-acquired respiratory infection is the commonest cause of sepsis presenting to emergency departments. Yet current experimental animal models simulate peritoneal sepsis with intraperitoneal (I.P.) injection of lipopolysaccharide (LPS
Externí odkaz:
https://doaj.org/article/d91fe190c2a04f89bfea12f86eb0c161
Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infection.
Autor:
Trevenan Walther, Rositsa Karamanska, Renee W Y Chan, Michael C W Chan, Nan Jia, Gillian Air, Clark Hopton, Maria P Wong, Anne Dell, J S Malik Peiris, Stuart M Haslam, John M Nicholls
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003223 (2013)
The first step in influenza infection of the human respiratory tract is binding of the virus to sialic (Sia) acid terminated receptors. The binding of different strains of virus for the receptor is determined by the α linkage of the sialic acid to g
Externí odkaz:
https://doaj.org/article/583765bd90754878a449037918e42426
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34160 (2012)
BACKGROUND: Very little is known regarding the persistence of Highly Pathogenic Avian Influenza (HPAI) H5N1 viruses in aquatic environments in tropical countries, although environmental materials have been suggested to play a role as reservoirs and s
Externí odkaz:
https://doaj.org/article/14dc2c51890a4d9a98e62072a2ed4d2b
Autor:
Chunfang Hu, Wenbin Wei, Xiaoyi Chen, Ciaran B Woodman, Yunhong Yao, John M Nicholls, Irène Joab, Sim K Sihota, Jian-Yong Shao, K Dalia Derkaoui, Aicha Amari, Stephanie L Maloney, Andrew I Bell, Paul G Murray, Christopher W Dawson, Lawrence S Young, John R Arrand
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41055 (2012)
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesi
Externí odkaz:
https://doaj.org/article/8f662a7d54aa4ae18f6d06c5d45f7c40
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51057 (2012)
The pathogenesis of human influenza H5N1 virus infection remains poorly understood and controversial. Cytokine dysregulation in human infection has been hypothesized to contribute to disease severity. We developed in vitro cultures of mouse bone marr
Externí odkaz:
https://doaj.org/article/296fbdf8b9e24b248a5ca5b40735d0c2
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28609 (2011)
BACKGROUND: The Highly Pathogenic Avian Influenza H5N1 virus has dramatically spread throughout Southeast Asia since its first detection in 1997. Merit Release Birds, such as the Eurasian Tree Sparrow, are believed to increase one's positive karma wh
Externí odkaz:
https://doaj.org/article/bd286e2fcba047caa54674cbf442c268
Autor:
Danlin Jia, Ramtin Rahbar, Renee W Y Chan, Suki M Y Lee, Michael C W Chan, Ben Xuhao Wang, Darren P Baker, Bing Sun, J S Malik Peiris, John M Nicholls, Eleanor N Fish
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13927 (2010)
Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and influencing the activation of various immune cells. Viruses such as influenza have developed mecha
Externí odkaz:
https://doaj.org/article/8c0f5d8c214f42d38650d89baf78a12d
Autor:
Renee W Y Chan, Kit M Yuen, Wendy C L Yu, Carol C C Ho, John M Nicholls, J S Malik Peiris, Michael C W Chan
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8713 (2010)
Influenza H5N1 virus continues to be enzootic in poultry and transmits zoonotically to humans. Although a swine-origin H1N1 virus has emerged to become pandemic, its virulence for humans remains modest in comparison to that seen in zoonotic H5N1 dise
Externí odkaz:
https://doaj.org/article/72a35012b3204b9c9b75b940bf88aa27
Autor:
Gallen B Triana-Baltzer, Larisa V Gubareva, John M Nicholls, Melissa B Pearce, Vasiliy P Mishin, Jessica A Belser, Li-Mei Chen, Renee W Y Chan, Michael C W Chan, Maria Hedlund, Jeffrey L Larson, Ronald B Moss, Jacqueline M Katz, Terrence M Tumpey, Fang Fang
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7788 (2009)
The recent emergence of a novel pandemic influenza A(H1N1) strain in humans exemplifies the rapid and unpredictable nature of influenza virus evolution and the need for effective therapeutics and vaccines to control such outbreaks. However, resistanc
Externí odkaz:
https://doaj.org/article/41fbea0695cb45de85d29444673103fb
Autor:
Olive T W Li, Michael C W Chan, Cynthia S W Leung, Renee W Y Chan, Yi Guan, John M Nicholls, Leo L M Poon
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5658 (2009)
Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mam
Externí odkaz:
https://doaj.org/article/775ebfc9ae7e4f5f9e7570b7305fbe07