Zobrazeno 1 - 10
of 207
pro vyhledávání: '"John M Luk"'
Autor:
Mary McMahon, Adrian Contreras, Mikael Holm, Tamayo Uechi, Craig M Forester, Xiaming Pang, Cody Jackson, Meredith E Calvert, Bin Chen, David A Quigley, John M Luk, R Kate Kelley, John D Gordan, Ryan M Gill, Scott C Blanchard, Davide Ruggero
Publikováno v:
eLife, Vol 8 (2019)
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in ce
Externí odkaz:
https://doaj.org/article/049984ff3ff540b49c64893eccc6ff9f
Autor:
Ji Hoon Kim, Bo Hwa Sohn, Hyun-Sung Lee, Sang-Bae Kim, Jeong Eun Yoo, Yun-Yong Park, Woojin Jeong, Sung Sook Lee, Eun Sung Park, Ahmed Kaseb, Baek Hui Kim, Wan Bae Kim, Jong Eun Yeon, Kwan Soo Byun, In-Sun Chu, Sung Soo Kim, Xin Wei Wang, Snorri S Thorgeirsson, John M Luk, Koo Jeong Kang, Jeonghoon Heo, Young Nyun Park, Ju-Seog Lee
Publikováno v:
PLoS Medicine, Vol 11, Iss 12, p e1001770 (2014)
BACKGROUND: Typically observed at 2 y after surgical resection, late recurrence is a major challenge in the management of hepatocellular carcinoma (HCC). We aimed to develop a genomic predictor that can identify patients at high risk for late recurre
Externí odkaz:
https://doaj.org/article/06bad4d2b4fe4e5290542ae8d50d884e
Autor:
Angela M Liu, Zhi Xu, Felix H Shek, Kwong-Fai Wong, Nikki P Lee, Ronnie T Poon, Jinfei Chen, John M Luk
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86872 (2014)
In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize aerobic glycolysis (Warburg's effect), with benefit of providing intermediates for biomass p
Externí odkaz:
https://doaj.org/article/45321d802302417ab9575fa294725dba
Autor:
Yonggang Wang, Felix H Shek, Kwong F Wong, Ling Xiao Liu, Xiao Qian Zhang, Yi Yuan, Ester Khin, Mei-Yu Hu, Jian Hua Wang, Ronnie T P Poon, Wanjin Hong, Nikki P Lee, John M Luk
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72386 (2013)
Cadherin-17 (CDH17) is an oncofetal molecule associated with poor prognostic outcomes of hepatocellular carcinoma (HCC), for which the treatment options are very limited. The present study investigates the therapeutic potential of a monoclonal antibo
Externí odkaz:
https://doaj.org/article/541a922c573b4e4fa86211a45660f3b1
Autor:
Jian Li, George Lau, Leilei Chen, Yun-Fei Yuan, Jun Huang, John M Luk, Dan Xie, Xin-Yuan Guan
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46264 (2012)
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most popular cancers in the world with poor prognosis, which often develops from chronic liver inflammatory diseases. Interleukin 23 (IL-23) is an inflammatory cytokine which is reported to pla
Externí odkaz:
https://doaj.org/article/b223f99113614e5a8561635935fc3d9b
Autor:
John R Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Ke Hao, Eugene Chudin, Hunter B Fraser, Joshua Millstein, Mark Ferguson, Christine Suver, Irena Ivanovska, Martin Scott, Ulrike Philippar, Dimple Bansal, Zhan Zhang, Julja Burchard, Ryan Smith, Danielle Greenawalt, Michele Cleary, Jonathan Derry, Andrey Loboda, James Watters, Ronnie T P Poon, Sheung T Fan, Chun Yeung, Nikki P Y Lee, Justin Guinney, Cliona Molony, Valur Emilsson, Carolyn Buser-Doepner, Jun Zhu, Stephen Friend, Mao Mao, Peter M Shaw, Hongyue Dai, John M Luk, Eric E Schadt
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20090 (2011)
BackgroundIn hepatocellular carcinoma (HCC) genes predictive of survival have been found in both adjacent normal (AN) and tumor (TU) tissues. The relationships between these two sets of predictive genes and the general process of tumorigenesis and di
Externí odkaz:
https://doaj.org/article/b53d4a768873417aa36a0629f6eecc3f
Autor:
Jian Li, George Ka-Kit Lau, Leilei Chen, Sui-sui Dong, Hui-Yao Lan, Xiao-Ru Huang, Yan Li, John M Luk, Yun-Fei Yuan, Xin-yuan Guan
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21816 (2011)
BACKGROUND: IL-17A is a pro-inflammatory cytokine that plays important role in inflammatory disease pathology and tumor microenvironment. The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC
Externí odkaz:
https://doaj.org/article/2842e63431c94f50b5afe2fca9046399
Autor:
Irena Ivanovska, Chunsheng Zhang, Angela M Liu, Kwong F Wong, Nikki P Lee, Patrick Lewis, Ulrike Philippar, Dimple Bansal, Carolyn Buser, Martin Scott, Mao Mao, Ronnie T P Poon, Sheung Tat Fan, Michele A Cleary, John M Luk, Hongyue Dai
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24582 (2011)
Biomarkers derived from gene expression profiling data may have a high false-positive rate and must be rigorously validated using independent clinical data sets, which are not always available. Although animal model systems could provide alternative
Externí odkaz:
https://doaj.org/article/1a6968a013d74f12988b1620ffe531a4
Autor:
Julja Burchard, Chunsheng Zhang, Angela M Liu, Ronnie T P Poon, Nikki P Y Lee, Kwong‐Fai Wong, Pak C Sham, Brian Y Lam, Mark D Ferguson, George Tokiwa, Ryan Smith, Brendan Leeson, Rebecca Beard, John R Lamb, Lee Lim, Mao Mao, Hongyue Dai, John M Luk
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)–gene interaction network in carcinogenesis, we examined their genome‐wide expression profiles in 96 pairs of tumor/non‐tumor tissues from hepatocellular car
Externí odkaz:
https://doaj.org/article/50bc46a5e0da45ebb7e123909cce0639
Autor:
Xiao Meng Pei, Heong Ting Wong, Simon Siu Man Ng, Wing Wa Leung, Yee Ni Wong, Hin Fung Tsang, Amanda Kit Ching Chan, Yin Kwan Evelyn Wong, Allen Chi Shing Yu, Aldrin Kay Yuen Yim, William Chi Shing Cho, John Kwok Cheung Chan, Kwong Fai Wong, John M Luk, William Chi Shing Tai, Sze Chuen Cesar Wong
Publikováno v:
Expert Review of Molecular Diagnostics. 23:171-179