Zobrazeno 1 - 10
of 181
pro vyhledávání: '"John M Harlan"'
Autor:
Akiko Iwata, R Angelo de Claro, Vicki L Morgan-Stevenson, Joan C Tupper, Barbara R Schwartz, Li Liu, Xiaodong Zhu, Katherine C Jordan, Robert K Winn, John M Harlan
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14729 (2011)
Severe sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic manipulation of death and survival pathways has been shown to modulate organ
Externí odkaz:
https://doaj.org/article/3763326c217a4beda13f907baf8de85f
Autor:
Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles, Kevin C. Kain
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 24-33 (2017)
Abstract miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may contribute to the pathogenesis of
Externí odkaz:
https://doaj.org/article/56bbf8fe6dc4421fa32a5aa6aa24e667
Autor:
Thomas S Uldrick, Nixon Niyonzima, Jackson Orem, Henry Ddungu, Alfred Karagu, Abrahams Omoding, Julius Mwaiselage, John M. Harlan, Louis Ngendahayo, Marta Ferraresso, Sylivestor Kadhumbula, Joyce Balagadde-Kambugu, Katherine Tarlock, Clement D Okello, Suzanne D. Turner
Publikováno v:
The Lancet Haematology. 8:e756-e769
Summary Haematological malignancies account for almost 10% of all cancers diagnosed in sub-Saharan Africa, although the exact incidences and treatment outcomes are difficult to discern because population-based cancer registries in the region are stil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56e2252e8f3689a5e33381cd1f43e16
https://doi.org/10.1016/s2352-3026(21)00198-8
https://doi.org/10.1016/s2352-3026(21)00198-8
Publikováno v:
Journal of Clinical Oncology. 39:405-405
405 Background: Globally, gastrointestinal (GI) cancers, which account for around 28% of all cancers, has increased constantly at a CAGR of 2% (2014-2019), while the treatment options remain limited and often ineffective. This is largely due to late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f76b553e42b343117c1575340d88915
https://doi.org/10.1200/jco.2021.39.3_suppl.405
https://doi.org/10.1200/jco.2021.39.3_suppl.405
Autor:
Anna E. Coghill, John M. Harlan, Manoj Menon, Warren Phipps, Corey Casper, Jackson Orem, Fred Okuku, Innocent Mutyaba
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191967 (2018)
PLoS ONE
PLoS ONE
Introduction Cancer treatment options in sub-Saharan Africa are scarce despite an increasing burden of disease. Identification of those cancer patients who would benefit most from the limited resources available would allow broader and more effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba46f79b04ebb4a4861290d78896f9e8
http://europepmc.org/articles/PMC5794100?pdf=render
http://europepmc.org/articles/PMC5794100?pdf=render
Autor:
W. Conrad Liles, Kevin R. Barker, Junmei Chen, Andrea L. Conroy, Makon-Sébastien Njock, Hani Kim, José A. López, Kevin C. Kain, Michael Hawkes, Ying Zheng, John M. Harlan, Henry S. Cheng, Jason E. Fish, Ziyue Lu
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 24-33 (2017)
miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may contribute to the pathogenesis of cerebral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf88df02f620392d83fbb7ee620041b
https://europepmc.org/articles/PMC5364112/
https://europepmc.org/articles/PMC5364112/
Autor:
John M. Harlan
Publikováno v:
Judges on Judging: Views from the Bench
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfefadf8c13e64702d561c5174b1a4a6
https://doi.org/10.4135/9781071800942.n12
https://doi.org/10.4135/9781071800942.n12
Autor:
Carole L. Wilson, Ivan G. Gomez, Wei Yan, Jingjing Tang, Elaine W. Raines, Jay W. Heinecke, John M. Harlan
Publikováno v:
Journal of Biological Chemistry. 287:4581-4589
Macrophage exiting from inflammatory sites is critical to limit the local innate immune response. With tissue insult, resident tissue macrophages rapidly efflux to lymph nodes where they modulate the adaptive immune response, and inflammatory macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a8a614c3106e3981b72899c360f1c9
https://doi.org/10.1074/jbc.m111.321182
https://doi.org/10.1074/jbc.m111.321182
Autor:
Pamela S. Becker, Kenneth J. Kopecky, Derek L. Stirewalt, Sylvia Chien, Frederick R. Appelbaum, Thalia Papayannopoulou, Cheryl L. Willman, John M. Harlan, Stephen H. Petersdorf, Adrianne N. Wilks
Publikováno v:
Blood. 113:866-874
Adhesion of acute myeloid leukemia (AML) blasts in the bone marrow microenvironment confers protection from chemotherapy-induced apoptosis. One mechanism for retention of blasts within the bone marrow is adhesion via very late antigen-4 (VLA-4), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632016a8e1e189b4d40f856f2b9ef822
https://doi.org/10.1182/blood-2007-12-124818
https://doi.org/10.1182/blood-2007-12-124818