Zobrazeno 1 - 10 of 121 pro vyhledávání: '"John M Hamlyn"'
1
Akademický článek
Inhibition of endogenous ouabain by atrial natriuretic peptide is a guanylyl cyclase independent effect.
Autor: Gulay Tegin, Yonglin Gao, John M Hamlyn, Barbara J Clark, Rif S El-Mallakh
Publikováno v: PLoS ONE, Vol 16, Iss 11, p e0260131 (2021)
BackgroundEndogenous ouabain (EO) and atrial natriuretic peptide (ANP) are important in regulation of sodium and fluid balance. There is indirect evidence that ANP may be involved in the regulation of endogenous cardenolides.MethodsH295R are human ad
Externí odkaz: https://doaj.org/article/082c946d0b5a4e9ebf73ff1eb912ee1b
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2
Akademický článek
Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control.
Autor: John M Hamlyn, Cristina I Linde, Junjie Gao, Bing S Huang, Vera A Golovina, Mordecai P Blaustein, Frans H H Leenen
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108916 (2014)
Central nervous system (CNS) administration of angiotensin II (Ang II) raises blood pressure (BP). The rise in BP reflects increased sympathetic outflow and a slower neuromodulatory pressor mechanism mediated by CNS mineralocorticoid receptors (MR).
Externí odkaz: https://doaj.org/article/0df3a099a042406bab64d41201224757
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3
Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension
Autor: Mordecai P. Blaustein, Stephen S. Gottlieb, John M. Hamlyn, Frans H. H. Leenen
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 323:H1281-H1295
Cloning of the “Na+ pump” (Na+,K+-ATPase or NKA) and identification of a circulating ligand, endogenous ouabain (EO), a cardiotonic steroid (CTS), triggered seminal discoveries regarding EO and its NKA receptor in cardiovascular function and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1345345ef94cf7afac112b32941534bc
https://doi.org/10.1152/ajpheart.00362.2022
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4
Inverse salt sensitivity: an independent risk factor for cardiovascular damage in essential hypertension
Autor: Ermira Cuka, Marco Simonini, Chiara Lanzani, Laura Zagato, Lorena Citterio, Elisabetta Messaggio, Sipontina Faienza, Elena Brioni, John M. Hamlyn, Paolo Manunta
Publikováno v: Journal of hypertension. 40(8)
Salt sensitivity is a powerful risk factor for cardiovascular (CV) disease and mortality in both normotensive and hypertensive patients. We investigated the predictive value of the salt sensitivity phenotype in the development of CV events and hypert
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0a149b6184797b47712342aa2f3d04
https://pubmed.ncbi.nlm.nih.gov/35881450
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5
Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel
Autor: Tultul Saha, Kazi Mirajul Hoque, Paramita Sarkar, Owen M. Woodward, Normand Leblanc, Andrea J. Bourdelais, John M. Hamlyn, Daniel G. Baden, Joydeep Aoun
Publikováno v: Pharmaceutical Biology, Vol 59, Iss 1, Pp 1008-1015 (2021)
Pharmaceutical Biology
article-version (VoR) Version of Record
Context Cucumber (Cucumis sativus Linn. [Cucurbitaceae]) is widely known for its purgative, antidiabetic, antioxidant, and anticancer therapeutic potential. However, its effect on gastrointestinal (GI) disease is unrecognised. Objective This study in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f2cf15c98a2ee17e38dc3c32fc15aa
https://doaj.org/article/4d4c56a7fd524cb48851e0eb97bd40fa
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8
Inhibition of endogenous ouabain by atrial natriuretic peptide is a guanylyl cyclase independent effect
Autor: Barbara J. Clark, John M. Hamlyn, Gulay Tegin, Rif S. El-Mallakh, Yonglin Gao
Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0260131 (2021)
Background Endogenous ouabain (EO) and atrial natriuretic peptide (ANP) are important in regulation of sodium and fluid balance. There is indirect evidence that ANP may be involved in the regulation of endogenous cardenolides. Methods H295R are human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760d690a68c3a83afd9045acb3956d09
https://pubmed.ncbi.nlm.nih.gov/34793577
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9
Abstract P039: The Endogenous Ouabain And Changes In Blood Pressure And Sodium Excretion Following An Acute Saline Load In Essential Hypertension
Autor: Paolo Manunta, John M. Hamlyn, Elisabetta Messaggio, Clarence E. Grim, Marco Simonini, Laura Zagato, Lorena Citterio, Chiara Lanzani
Publikováno v: Hypertension. 76
Among ~25% of patients with essential hypertension (EH), circulating endogenous ouabain (EO) and aldosterone (Aldo) are typically coelevated and their BP is especially salt-sensitive (SS). We probed for exaggerated natriuresis in a large cohort (712)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95d21c526b989c3d268b3335d58517f9
https://doi.org/10.1161/hyp.76.suppl_1.p039
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10
COVID-19 and Crosstalk between the Hallmarks of Aging
Autor: Shabnam Salimi, John M. Hamlyn
Within the past several decades, the emergence of new viral diseases with more severe health complications and mortality, primarily in older adults with comorbidities, is evidence of an age-dependent, compromised bodily response to abrupt stress with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1632d577c5d7ce6f1bd14675ed41cf00
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Plný text Recenzováno Digitální knihovna AV ČR
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