Zobrazeno 1 - 10
of 314
pro vyhledávání: '"John M Greally"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010567 (2023)
It is a generally accepted model that environmental influences can exert their effects, at least in part, by changing the molecular regulators of transcription that are described as epigenetic. As there is biochemical evidence that some epigenetic re
Externí odkaz:
https://doaj.org/article/f8cfd3b436a7441f9b5062b9fde59e13
Autor:
Netha Ulahannan, Ronald Cutler, Reanna Doña-Termine, Claudia A Simões-Pires, N Ari Wijetunga, Matthew McKnight Croken, Andrew D Johnston, Yu Kong, Shahina B Maqbool, Masako Suzuki, John M Greally
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275226 (2022)
To gain insights into the molecular interactions of an intracellular pathogen and its host cell, we studied the gene expression and chromatin states of human fibroblasts infected with the Apicomplexan parasite Toxoplasma gondii. We show a striking ac
Externí odkaz:
https://doaj.org/article/af22b0789185460b95069884872c8950
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215987 (2019)
Cell subtype proportion variability between samples contributes significantly to the variation of functional genomic properties such as gene expression or DNA methylation. Although the impact of the variation of cell subtype composition on measured g
Externí odkaz:
https://doaj.org/article/b565903f2d7548d3b1fc4944e32b3739
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006105 (2016)
Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human phenotypes. The epigenome is especially intriguing as a target for study, as epigenetic regulatory
Externí odkaz:
https://doaj.org/article/669a369641924a5ca6e503a58b35f4f6
Autor:
Maria Delio, Kunjan Patel, Alex Maslov, Robert W Marion, Thomas V McDonald, Evan M Cadoff, Aaron Golden, John M Greally, Jan Vijg, Bernice Morrow, Cristina Montagna
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133742 (2015)
While next generation sequencing (NGS) is a useful tool for the identification of genetic variants to aid diagnosis and support therapy decision, high sequencing costs have limited its application within routine clinical care, especially in economica
Externí odkaz:
https://doaj.org/article/b00fe29eba5d4aae922b4802bd2aa89e
Autor:
Esther R Berko, Masako Suzuki, Faygel Beren, Christophe Lemetre, Christine M Alaimo, R Brent Calder, Karen Ballaban-Gil, Batya Gounder, Kaylee Kampf, Jill Kirschen, Shahina B Maqbool, Zeineen Momin, David M Reynolds, Natalie Russo, Lisa Shulman, Edyta Stasiek, Jessica Tozour, Maria Valicenti-McDermott, Shenglong Wang, Brett S Abrahams, Joseph Hargitai, Dov Inbar, Zhengdong Zhang, Joseph D Buxbaum, Sophie Molholm, John J Foxe, Robert W Marion, Adam Auton, John M Greally
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004402 (2014)
DNA mutational events are increasingly being identified in autism spectrum disorder (ASD), but the potential additional role of dysregulation of the epigenome in the pathogenesis of the condition remains unclear. The epigenome is of interest as a pos
Externí odkaz:
https://doaj.org/article/a803dd8795744243ae732bdcac7b9739
Autor:
John M Greally
Publikováno v:
eLife, Vol 2 (2013)
Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
Externí odkaz:
https://doaj.org/article/5147c2d8d2d140afa454d25562b40150
Autor:
Adam Auton, Ying Rui Li, Jeffrey Kidd, Kyle Oliveira, Julie Nadel, J Kim Holloway, Jessica J Hayward, Paula E Cohen, John M Greally, Jun Wang, Carlos D Bustamante, Adam R Boyko
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003984 (2013)
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals
Externí odkaz:
https://doaj.org/article/900bd09f64624507874ce0821cbe7a35
Autor:
Maher Hanoun, Lewin Eisele, Masako Suzuki, John M Greally, Andreas Hüttmann, Semra Aydin, René Scholtysik, Ludger Klein-Hitpass, Ulrich Dührsen, Jan Dürig
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34347 (2012)
Disruption of circadian rhythm is believed to play a critical role in cancer development. Cryptochrome 1 (CRY1) is a core component of the mammalian circadian clock and we have previously shown its deregulated expression in a subgroup of patients wit
Externí odkaz:
https://doaj.org/article/90463603a82440d4a52cfa3953def144
Autor:
Hector Alvarez, Joanna Opalinska, Li Zhou, Davendra Sohal, Melissa J Fazzari, Yiting Yu, Christina Montagna, Elizabeth A Montgomery, Marcia Canto, Kerry B Dunbar, Jean Wang, Juan Carlos Roa, Yongkai Mo, Tushar Bhagat, K H Ramesh, Linda Cannizzaro, J Mollenhauer, Reid F Thompson, Masako Suzuki, Stephen J Meltzer, Ari Melnick, John M Greally, Anirban Maitra, Amit Verma
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001356 (2011)
Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unk
Externí odkaz:
https://doaj.org/article/6a4dfe7d74b147538ce4d65d3a9a0ab9