Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John M Finke"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120420 (2015)
The fraction of IgG antibodies with anti-oligomeric Aβ affinity and surface sialic acid was compared between Octagam and Gammagard intravenous immunoglobulin (IVIG) using two complementary surface plasmon resonance methods. These comparisons were pe
Externí odkaz:
https://doaj.org/article/a715aecdbf8c47d5935b4e42fa52d6b9
Publikováno v:
The journal of physical chemistry. B. 126(48)
Formation of protein knots is an intriguing offshoot of the protein folding problem. Since experimental resolution on knot formation is limited, theoretical methods currently provide the most detailed insights into the knotting process. While suitabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65ff0bbc4b99e8260fa306df788a33f
https://pubmed.ncbi.nlm.nih.gov/36424347
https://pubmed.ncbi.nlm.nih.gov/36424347
Autor:
John M. Finke, William A. Banks
Publikováno v:
Human Antibodies. 25:131-146
This review serves to highlight approaches that may improve the access of antibody drugs to regions of the brain affected by Alzheimer's Disease. While previous antibody drugs have been unsuccessful in treating Alzheimer's disease, recent work demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7317dc5e14683c473a52f09bdf9fe9c2
https://doi.org/10.3233/hab-160306
https://doi.org/10.3233/hab-160306
Autor:
John M. Finke, Lynnae M. Smith, David A. Loeffler, Loan Dang, Adam L. Yokom, Amanda C. Crisostomo, Jeremiah J. Payne, Jyothi L. Digambaranath, Andrea C. Klaver
Publikováno v:
Data in Brief
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
Data in Brief, Vol 4, Iss C, Pp 650-658 (2015)
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as soluble oligomer and amyloid fibril products from a slow (3–4 week) assembly reaction und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963d9127e70314edf466791d06173849
http://europepmc.org/articles/PMC4560727
http://europepmc.org/articles/PMC4560727
Autor:
Adam L. Yokom, Lynnae M. Smith, Amanda C. Crisostomo, Andrea C. Klaver, Jyothi L. Digambaranath, Loan Dang, David A. Loeffler, Jeremiah J. Payne, John M. Finke
Publikováno v:
Analytical Biochemistry. 481:43-54
Surface plasmon resonance was used to investigate the kinetics, affinity, and specificity of binding between anti-Aβ (beta-amyloid) IgG antibodies and oligomeric Aβ. Two factors were needed to accurately characterize the IgG binding kinetics. First
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8c0616e4a79afd7589195216ba60f4
https://doi.org/10.1016/j.ab.2015.03.032
https://doi.org/10.1016/j.ab.2015.03.032
Publikováno v:
International Journal for Ion Mobility Spectrometry. 16:133-143
Understanding protein tertiary and quaternary structures is crucial to a better understanding of their biological functions. Here we illustrate for tryptophan synthase that tandem mass spectrometry (MS/MS) reveals not only protein subunit architectur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1764cce2ed0a7cbe037fc1ab67f9ca
https://doi.org/10.1007/s12127-013-0126-4
https://doi.org/10.1007/s12127-013-0126-4
Publikováno v:
Biochimica et biophysica acta. General subjects. 1861(9)
Background Drug delivery to the brain is a major roadblock to treatment of Alzheimer's disease. Recent results of the PRIME study indicate that increasing brain penetration of antibody drugs improves Alzheimer's treatment outcomes. New approaches are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849947e70a7643070e909ac36194c166
https://pubmed.ncbi.nlm.nih.gov/28624473
https://pubmed.ncbi.nlm.nih.gov/28624473
Autor:
Michael J. McPhail, Tyler V. Campbell, Alfred Chung, Karis E. Stevenson, Mohamed Zohdy, John M. Finke, Jyothi L. Digambaranath
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 79:1427-1440
Polyglutamine repeats in proteins are highly correlated with amyloid formation and neurological disease. To better understand the molecular basis of glutamine repeat diseases, structural analysis of polyglutamine peptides as soluble monomers, oligome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cc0c61e14bca42df243a0a28b7ce4b9
https://doi.org/10.1002/prot.22970
https://doi.org/10.1002/prot.22970
Autor:
Roman Dembinski, Deepthi Khanduri, Adam Sniady, Michael D. Sevilla, Tadeusz Lis, John M. Finke, Srinivasarao Meneni, Sławomir Szafert
Publikováno v:
Chemistry - A European Journal. 15:7569-7577
Sonogashira coupling of diacetyl 5-ethynyl-2′-deoxyuridine with diacetyl 5-iodo-2′-deoxyuridine gave the acylated ethynediyl-linked 2′-deoxyuridine dimer (3 b; 63 %), which was deprotected with ammonia/methanol to give ethynediyl-linked 2′-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936c7fa121ccd1bdbca1d19421750c81
https://doi.org/10.1002/chem.200900481
https://doi.org/10.1002/chem.200900481
Publikováno v:
Journal of Molecular Biology. 374:528-546
The structures of partially folded states appearing during the folding of a (betaalpha)(8) TIM barrel protein, the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus (sIGPS), was assessed by hydrogen exchange mass spectrometry (HX-MS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3eea5c1b9b5c8fa9b71d2022d11536
https://doi.org/10.1016/j.jmb.2007.09.024
https://doi.org/10.1016/j.jmb.2007.09.024