Zobrazeno 1 - 10
of 345
pro vyhledávání: '"John M Coffin"'
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001826 (2022)
Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA-seq dataset from normal tissue sampled at autopsy, we characterized individual
Externí odkaz:
https://doaj.org/article/81705d20b7d34c80a4553b84661889ae
Autor:
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://doaj.org/article/3e177632677e4f3b9ab7e952f1029063
Autor:
Andrea L Ferris, David W Wells, Shuang Guo, Gregory Q Del Prete, Adrienne E Swanstrom, John M Coffin, Xiaolin Wu, Jeffrey D Lifson, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007869 (2019)
Clonal expansion of HIV infected cells plays an important role in the formation and persistence of the reservoir that allows the virus to persist, in DNA form, despite effective antiretroviral therapy. We used integration site analysis to ask if ther
Externí odkaz:
https://doaj.org/article/5e65d44819954b439ce25fc7838a7478
Autor:
Mary F Kearney, Jonathan Spindler, Ann Wiegand, Wei Shao, Richard Haubrich, Sharon Riddler, Christina M Lalama, Michael D Hughes, John M Coffin, John W Mellors
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190438 (2018)
BACKGROUND:Identifying pre-ART factors associated with the emergence of HIV-1 drug resistance is critical for optimizing strategies to prevent virologic failure. A previous study reported that lower pre-ART HIV-1 pol diversity was associated with hig
Externí odkaz:
https://doaj.org/article/cfc076244510432a915859604347eaa0
Autor:
Julia H Wildschutte, John M Coffin
Publikováno v:
eLife, Vol 6 (2017)
Primates have co-opted a viral gene to produce an envelope protein that prevents infection by the HERV-T virus and likely contributed to the extinction of this virus.
Externí odkaz:
https://doaj.org/article/2943d66dda8344a2b8d6fae0c364ca1c
Autor:
John K Bui, Michele D Sobolewski, Brandon F Keele, Jonathan Spindler, Andrew Musick, Ann Wiegand, Brian T Luke, Wei Shao, Stephen H Hughes, John M Coffin, Mary F Kearney, John W Mellors
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006283 (2017)
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive a
Externí odkaz:
https://doaj.org/article/d81e82ce9351408f8840cc2e9444e380
Publikováno v:
PLoS Genetics, Vol 3, Iss 10, Pp 2014-2022 (2007)
The ability of human and murine APOBECs (specifically, APOBEC3) to inhibit infecting retroviruses and retrotransposition of some mobile elements is becoming established. Less clear is the effect that they have had on the establishment of the endogeno
Externí odkaz:
https://doaj.org/article/deea6fa411b249959acdfc42964c3e0d
Autor:
Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon, John M. Coffin, Daniel D. DeCarvalho, Joseph D. Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K. Knutson, Arnold J. Levine, Avindra Nath, Sophie Papa, Daniel Rios, John Sedivy, David T. Ting
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape
Externí odkaz:
https://doaj.org/article/afb42101dc1c4afbabb0c6b4ea01ef97
Autor:
Mary F Kearney, Jonathan Spindler, Wei Shao, Sloane Yu, Elizabeth M Anderson, Angeline O'Shea, Catherine Rehm, Carry Poethke, Nicholas Kovacs, John W Mellors, John M Coffin, Frank Maldarelli
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1004010 (2014)
A better understanding of changes in HIV-1 population genetics with combination antiretroviral therapy (cART) is critical for designing eradication strategies. We therefore analyzed HIV-1 genetic variation and divergence in patients' plasma before cA
Externí odkaz:
https://doaj.org/article/5e79a5c84d0242e3801880d4e7d8f9e4
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004179 (2014)
Externí odkaz:
https://doaj.org/article/46494929b3614c1e9af2961e978b9065