Výsledky vyhledávání - "John M Canty"

Akademický článek

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro.

Autor: Jennifer K Lang, Rebeccah F Young, Hashmat Ashraf, John M Canty

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165926 (2016)

Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function. However, it has not yet been d

Externí odkaz: https://doaj.org/article/6f18ed8e0402420a96916fa561675397

Zobrazit plný text záznamu

Akademický článek

Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium.

Autor: Gen Suzuki, Brian R Weil, Merced M Leiker, Amanda E Ribbeck, Rebeccah F Young, Thomas R Cimato, John M Canty

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e113009 (2014)

Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique. Unfortunately, myocyte loss and dysfunction occur globally in many patients wit

Externí odkaz: https://doaj.org/article/284f92a0ce214e119953e16fb3e7a9a8

Zobrazit plný text záznamu

Akademický článek

Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart.

Autor: Wen Wang, Jennifer K Lang, Gen Suzuki, John M Canty, Thomas Cimato

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24868 (2011)

BackgroundCoronary artery disease and ischemic heart disease are leading causes of heart failure and death. Reduced blood flow to heart tissue leads to decreased heart function and symptoms of heart failure. Therapies to improve heart function in chr

Externí odkaz: https://doaj.org/article/8ff42e6c75d947449d6f5799f44ff633

Zobrazit plný text záznamu

Akademický článek

Galectin-3 Is Associated with Cardiac Fibrosis and an Increased Risk of Sudden Death

Autor: Mingma D. Sherpa, Swati D. Sonkawade, Vinesh Jonnala, Saraswati Pokharel, Mahyar Khazaeli, Yan Yatsynovich, Mohamad A. Kalot, Brian R. Weil, John M. Canty, Umesh C. Sharma

Publikováno v: Cells, Vol 12, Iss 9, p 1218 (2023)

Background: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium is associated with high

Externí odkaz: https://doaj.org/article/f10e896244b946eb8ad9d678205dd228

Zobrazit plný text záznamu

Plný text ve formátu HTML

Widespread intracoronary allogeneic cardiosphere-derived cell therapy with and without cyclosporine in reperfused myocardial infarction

Autor: George Techiryan, Brian R. Weil, Rebeccah F. Young, John M. Canty

Publikováno v: American journal of physiology. Heart and circulatory physiology. 323(5)

In a three-way blinded, randomized design, we determined whether allogeneic CDCs administered at reperfusion improved myocardial function and whether intravenous cyclosporine enhanced their efficacy. In contrast to prior studies using oral cyclospori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82eaf866dc9a0e567cecf29ef4029d9
https://pubmed.ncbi.nlm.nih.gov/36083793

Zobrazit plný text záznamu

Does quantification of [11C]meta-hydroxyephedrine and [13N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy

Autor: Aaryn Lavallee, Jason G.E. Zelt, Benjamin H. Rotstein, Rob S. Beanlands, Jennifer M. Renaud, Nicole Kaps, Jean Z. Wang, James A. Fallavollita, Robert A. deKemp, John M. Canty

Publikováno v: Journal of Nuclear Cardiology. 29:413-425

In ischemic cardiomyopathy patients, cardiac sympathetic nervous system dysfunction is a predictor of sudden cardiac arrest (SCA). This study compared abnormal innervation and perfusion measured by [11C]meta-hydroxyephedrine (HED) vs [13N]ammonia (NH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f60b6aa6e9b5eb69f9f1b5b8d66bbb5
https://doi.org/10.1007/s12350-021-02732-5

Zobrazit plný text záznamu

Gaining Efficiency in Clinical Trials With Cardiac Biomarkers

Publikováno v: Journal of the American College of Cardiology. 77:1922-1933

The momentum of cardiovascular drug development has slowed dramatically. Use of validated cardiac biomarkers in clinical trials could accelerate development of much-needed therapies, but biomarkers have been used less for cardiovascular drug developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f647eaea221c1fe1deaac2fc73692fa1
https://doi.org/10.1016/j.jacc.2021.02.040

Zobrazit plný text záznamu

Changes in Field Termination of Resuscitation and Survival Rates After an Educational Intervention to Promote on Scene Resuscitation for Out-of-Hospital Cardiac Arrest

Autor: Robert Orlowski, John M. Canty, Michael R. Waldrop, David Hostler, Lynn J. White, Johanna Innes, Eric Dievendorf, Kejia Wang, Heather A. Lindstrom, Brian M. Clemency

Publikováno v: J Emerg Med

Background Emergency medical services (EMS) agencies with higher field termination-of-resuscitation (TOR) rates tend to have higher survival rates from out-of-hospital cardiac arrest (OHCA). Whether EMS agencies can improve survival rates through eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c908b6c32fac25cdc0620b0cd17a769
https://doi.org/10.1016/j.jemermed.2020.10.003

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání