Výsledky vyhledávání - "John M Abraham"

Akademický článek

Phosphorus-32, a clinically available drug, inhibits cancer growth by inducing DNA double-strand breakage.

Autor: Yulan Cheng, Ana P Kiess, Joseph M Herman, Martin G Pomper, Stephen J Meltzer, John M Abraham

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128152 (2015)

Radioisotopes that emit electrons (beta particles), such as radioiodine, can effectively kill target cells, including cancer cells. Aqueous 32P[PO4] is a pure beta-emitter that has been used for several decades to treat non-malignant human myeloproli

Externí odkaz: https://doaj.org/article/69cdc6cb840d403184553bc730760a83

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Akademický článek

Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells.

Autor: Rachana Agarwal, Yuriko Mori, Yulan Cheng, Zhe Jin, Alexandru V Olaru, James P Hamilton, Stefan David, Florin M Selaru, Jian Yang, John M Abraham, Elizabeth Montgomery, Patrice J Morin, Stephen J Meltzer

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e8002 (2009)

Claudins are membrane proteins that play critical roles in tight junction (TJ) formation and function. Members of the claudin gene family have been demonstrated to be aberrantly regulated, and to participate in the pathogenesis of various human cance

Externí odkaz: https://doaj.org/article/1ff85d7b6f96494baa02925f27c4c7de

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Akademický článek

Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy.

Autor: John M Abraham, Yulan Cheng, James P Hamilton, Bogdan Paun, Zhe Jin, Rachana Agarwal, Takatsugu Kan, Stefan David, Alexandru Olaru, Jian Yang, Tetsuo Ito, Florin M Selaru, Yuriko Mori, Stephen J Meltzer

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2508 (2008)

Cancers have been revealed to be extremely heterogenous in terms of the frequency and types of mutations present in cells from different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that th

Externí odkaz: https://doaj.org/article/7e4e0408aa8547bd9afe8634bc07a6a5

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Akademický článek

Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.

Publikováno v: PLoS ONE, Vol 3, Iss 4, p e1890 (2008)

Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter

Externí odkaz: https://doaj.org/article/448f834db6b2493aa69544cf81f2acc2

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Akademický článek

Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells.

Autor: John M Abraham, Fumiaki Sato, Yulan Cheng, Bogdan Paun, Takatsugu Kan, Alexandru Olaru, Zhe Jin, Jian Yang, Rachana Agarwal, Stefan David, James P Hamilton, Tetsuo Ito, Yuriko Mori, Stephen J Meltzer

Publikováno v: PLoS ONE, Vol 2, Iss 10, p e964 (2007)

The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.This report describes the discovery of nine novel decapeptides

Externí odkaz: https://doaj.org/article/4c9046db201645d584288b2b11f6bfc4

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