Zobrazeno 1 - 10
of 68
pro vyhledávání: '"John M, Yanni"'
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 21:139-148
The aim of this study was to establish a clinically relevant short-term animal model of dry eye with utility in identifying compounds with potential therapeutic efficacy.Rabbit lacrimal glands were injected with the T-cell mitogen Concanavalin A (Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea46660b88b94c9df555b7ccfb63047
https://doi.org/10.1089/jop.2005.21.139
https://doi.org/10.1089/jop.2005.21.139
Autor:
Milton T. Brady, M. H. Rawji, D. C. Dahlin, M. A. Kapin, M. E. Sanders, Daniel A. Gamache, T.J. McDonough, John M. Yanni, John G. Flanagan
Publikováno v:
Inflammation. 27:281-291
The purpose of this study was to evaluate the ability of the nonsteroidal anti-inflammatory drug nepafenac to prevent development of mitogen-induced pan-retinal edema following topical ocular application in the rabbit. Anesthetized Dutch Belted rabbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da6cfcd2904f2f0392cac25aa3e749a2
https://doi.org/10.1023/a:1026024409826
https://doi.org/10.1023/a:1026024409826
Autor:
Steven T. Miller, Howard L. Brockman, John M. Yanni, Gustav Graff, Maureen M. Momsen, Joshua R. Knudtson
Publikováno v:
Ocular Immunology and Inflammation. 11:247-268
Olopatadine, an effective topical ocular human conjunctival mast cell stabilizer/antihistaminic antiallergic drug, was evaluated and compared to selected classical antihistamines for their interaction with model and natural membranes to ascertain pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8facc164525815f97a6a9741ac8a6ec7
https://doi.org/10.1076/ocii.11.4.247.18261
https://doi.org/10.1076/ocii.11.4.247.18261
Autor:
Joan M. Spellman, Lori K. Weimer, Zhongyou Wei, Steven T. Miller, Daniel A. Gamache, John M. Yanni
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:349-361
The mucin secretagogue 15(S)-HETE was found to stimulate glycoprotein secretion in human ocular tissue at submicromolar concentrations in the present studies. Therefore, the ability of topically applied 15(S)-HETE to preserve corneal integrity was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38582453513422780e620ebf27ba8a5b
https://doi.org/10.1089/10807680260218515
https://doi.org/10.1089/10807680260218515
Publikováno v:
Acta Ophthalmologica Scandinavica. 78:10-15
Olopatadine is a human conjunctival mast cell stabilizer with antihistaminic activity. Ketotifen is an older molecule that possesses antihistaminic activity and is reported to have additional pharmacological properties. The interactions of these two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf23e0774d43fdf294ce4197c5ffc3
https://doi.org/10.1034/j.1600-0420.2000.078s230010.x
https://doi.org/10.1034/j.1600-0420.2000.078s230010.x
Publikováno v:
Inflammation. 24:357-370
Nepafenac, the amide analog of 2-amino-3-benzoylbenzeneacetic acid (amfenac), was examined in preclinical models for its potential utility as a topical ocular anti-inflammatory agent. Diclofenac was selected as the reference compound. In contrast to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c98f30c455cd81904d2b5c751aeddd36
https://doi.org/10.1023/a:1007049015148
https://doi.org/10.1023/a:1007049015148
Publikováno v:
Inflammation. 24:371-384
Nepafenac, the amide analog of the NSAID amfenac, was examined in vitro for its bioactivation by ocular tissue components and its ability to permeate external ocular barriers. Rabbit tissues catalyzed a concentration-dependent conversion of nepafenac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a18f33fb0014c843e409a5a6fb17333c
https://doi.org/10.1023/a:1007001131987
https://doi.org/10.1023/a:1007001131987
Autor:
Daniel A. Gamache, Najam A. Sharif, Joan M. Spellman, John M. Yanni, Lori K. Weimer, Steven T. Miller
Publikováno v:
Acta Ophthalmologica Scandinavica. 77:33-37
Two important realizations about pathophysiological mechanisms involved in allergic conjunctivitis have led to novel drug discovery efforts and new topical ocular medications for prevention and treatment of this prevent allergic disease. The first of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3699137aa28377915abcb6c8cd486
https://doi.org/10.1111/j.1600-0420.1999.tb01171.x
https://doi.org/10.1111/j.1600-0420.1999.tb01171.x
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 15:413-423
Ocular neovascular diseases represent a major cause of blindness in the world. Angiostatic steroids are a unique class of compounds which inhibit the formation of new blood vessels in various models, including ocular models of angiogenesis. In search
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b8a4a8977e09ad004cad2d660a5a0
https://doi.org/10.1089/jop.1999.15.413
https://doi.org/10.1089/jop.1999.15.413
Publikováno v:
International Archives of Allergy and Immunology. 115:288-293
The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner. The histamine antagonists emedastine (H1), ranitidine (H2) and thioperamide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566c523a926906a0266becf3c6211a22
https://doi.org/10.1159/000069459
https://doi.org/10.1159/000069459