Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John M, Kreeger"'
Autor:
Ryan M. Esquejo, Christopher T. Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, Chuong Nguyen, Kieran F. Geoghegan, John M. Kreeger, Alan Opsahl, Jessica Ward, Amit S. Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F. Osborne, Gregory R. Steinberg, Morris J. Birnbaum, Kimberly O. Cameron, Russell A. Miller
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 122-132 (2018)
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://doaj.org/article/3a6b1a8ecd964eee8550aafb2b27ef05
Autor:
Rachel J Church, Shelli J Schomaker, J Scott Eaddy, Germaine G Boucher, John M Kreeger, Jiri Aubrecht, Paul B Watkins
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240562 (2020)
Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH is located within the mitochondrial matrix, it has been hypothesized that it might also be
Externí odkaz:
https://doaj.org/article/4b07e64a012741b78f47489226cafa94
Autor:
Germaine Boucher, Rachel J. Church, John M. Kreeger, Paul B. Watkins, Shelli J. Schomaker, J. Scott Eaddy, Jiri Aubrecht
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240562 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240562 (2020)
Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH is located within the mitochondrial matrix, it has been hypothesized that it might also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd59f00575c24ff15ec8f7876db259a9
https://pubmed.ncbi.nlm.nih.gov/33035276
https://pubmed.ncbi.nlm.nih.gov/33035276
Autor:
Jessica Ward, Jason Barricklow, Chuong Nguyen, Eliza Bollinger, Christopher T. Salatto, Bina Albuquerque, Mara Monetti, Norimitsu Shirai, Emily A. Day, Emily Cokorinos, Kieran F. Geoghegan, Gregory R. Steinberg, Rob Moccia, Matthew Peloquin, Ryan M. Esquejo, Morris J. Birnbaum, Russell A. Miller, Alan C. Opsahl, Brennan K. Smith, Jake Delmore, Kimberly O. Cameron, Timothy F. Osborne, Allan R. Reyes, John M. Kreeger, Lynne Butler, David A. Tess, Amit S. Kalgutkar, Yuji Shi
Publikováno v:
EBioMedicine, Vol 31, Iss, Pp 122-132 (2018)
EBioMedicine
EBioMedicine
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f1c5af9f8bcc8ab432732a5031a0fe
http://www.sciencedirect.com/science/article/pii/S2352396418301373
http://www.sciencedirect.com/science/article/pii/S2352396418301373
Autor:
Hans-Peter Gerber, Chunli Huang, Leslie A. Obert, Magali Guffroy, Germaine Boucher, Richard Goldstein, Karen Walters, Danielle Sullivan, Hadi Falahatpisheh, William J. Reagan, John M. Kreeger, Nasir K. Khan, Tim M. Coskran, Kathleen Biddle, Richard P. Giovanelli, Sharon A. Sokolowski, Martin Finkelstein
Publikováno v:
Clinical Cancer Research. 23:1760-1770
Purpose: Adverse reactions reported in patients treated with antibody–calicheamicin conjugates such as gemtuzumab ozogamicin (Mylotarg) and inotuzumab ozogamicin include thrombocytopenia and sinusoidal obstruction syndrome (SOS). The objective of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cc14d6604e232f8e412e34715ae0ed
https://doi.org/10.1158/1078-0432.ccr-16-0939
https://doi.org/10.1158/1078-0432.ccr-16-0939
Autor:
Paul DaSilva-Jardine, Jessica Ward, Katherine Cialdea, Matthew F. Calabrese, Marina Amaro, Harmeet Gandhok, Francis Rajamohan, Alan C. Opsahl, Mara Monetti, Kimberly O. Cameron, Tim Rolph, Eliza Bollinger, Benjamin S. Maciejewski, Ravi G. Kurumbail, Christopher T. Salatto, Timothy M. Coskran, David A. Tess, Aditi Jatkar, Nathan E. Genung, Emily Cokorinos, Allan R. Reyes, Morris J. Birnbaum, Germaine Boucher, John M. Kreeger, Andre Shavnya, David J. Edmonds, Russell A. Miller, Amit S. Kalgutkar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:303-311
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine monophosphate-activated protein kinase (AMPK) has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66e0afa566f1f67e7eeedde3c3b2a37
https://doi.org/10.1124/jpet.116.237925
https://doi.org/10.1124/jpet.116.237925
Autor:
Russell C. Cattley, Satoko Kakiuchi-Kiyota, Samuel M. Cohen, John M. Kreeger, Shuhua Xia, Jon C. Cook, Danielle M. Crowell, Marc D. Roy, Torrie A. Crabbs, Leslie A. Obert, Timothy M. Coskran
Publikováno v:
Toxicologic pathology. 48(3)
Several chemicals and pharmaceuticals increase the incidence of hemangiosarcomas (HSAs) in mice, but the relevance to humans is uncertain. Recently, canine HSAs were identified as a powerful tool for investigating the pathogenesis of human HSAs. To c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786645bec816da62c6c6ba92741d995
https://pubmed.ncbi.nlm.nih.gov/31918642
https://pubmed.ncbi.nlm.nih.gov/31918642
Autor:
E. Clive Joseph, Teri Conte, Ben Deeley, Susan Portugal, Bradley E. Enerson, Sharon A. Sokolowski, Todd Wisialowski, John M. Kreeger, Catherine Rief, Michael P. Lawton, Paul Nugent, Terri A. Swanson, Leslie A. Obert
Publikováno v:
Toxicologic Pathology. 42:784-791
Several classes of drugs have been shown to cause drug-induced vascular injury (DIVI) in preclinical toxicity studies. Measurement of blood flow and vessel diameter in numerous vessels and across various tissues by ultrasound imaging has the potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa4239055d114e420cf2fd06e0e1dc4
https://doi.org/10.1177/0192623314525687
https://doi.org/10.1177/0192623314525687
Publikováno v:
Toxicologic Pathology. 42:1082-1091
In a 2-year rat carcinogenicity study, pegvisomant injected subcutaneously on a daily basis at doses of 0, 2, 8, or 20 mg/kg/day produced malignant fibrous histiocytomas (MFHs) at the injection sites of 3 male rats (5%) given 8 mg/kg/day and 5 males
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2dd23d5123bd52f62b6e3ba2380c51
https://doi.org/10.1177/0192623313517772
https://doi.org/10.1177/0192623313517772
Autor:
Christopher T, Salatto, Russell A, Miller, Kimberly O, Cameron, Emily, Cokorinos, Allan, Reyes, Jessica, Ward, Matthew F, Calabrese, Ravi G, Kurumbail, Francis, Rajamohan, Amit S, Kalgutkar, David A, Tess, Andre, Shavnya, Nathan E, Genung, David J, Edmonds, Aditi, Jatkar, Benjamin S, Maciejewski, Marina, Amaro, Harmeet, Gandhok, Mara, Monetti, Katherine, Cialdea, Eliza, Bollinger, John M, Kreeger, Timothy M, Coskran, Alan C, Opsahl, Germaine G, Boucher, Morris J, Birnbaum, Paul, DaSilva-Jardine, Tim, Rolph
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Diabetic nephropathy remains an area of high unmet medical need, with current therapies that slow down, but do not prevent, the progression of disease. A reduced phosphorylation state of adenosine monophosphate-activated protein kinase (AMPK) has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dabb362de095f5aa2c5ef6849429242e
https://pubmed.ncbi.nlm.nih.gov/28289077
https://pubmed.ncbi.nlm.nih.gov/28289077