Zobrazeno 1 - 10
of 249
pro vyhledávání: '"John Lunec"'
Autor:
Hayden L. Bell, Helen J. Blair, Mankaran Singh, Anthony V. Moorman, Olaf Heidenreich, Frederik W. van Delft, John Lunec, Julie A. E. Irving
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve outcomes. Targeted inhibition of WEE1 with small-molecule inhibitor adavosertib (AZD1775) has emerg
Externí odkaz:
https://doaj.org/article/9deed2b8e0db4595931334af42559dac
Autor:
Erhan Aptullahoglu, Sirintra Nakjang, Jonathan P. Wallis, Helen Marr, Scott Marshall, Elaine Willmore, John Lunec
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1388 (2024)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically diverse hematological cancer affecting middle-aged and elderly individuals. Novel targeted therapy options are needed for patients who relapse following initial responses or who are i
Externí odkaz:
https://doaj.org/article/d985462f94fb48a19b17942c67dfd921
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Marco Youssef William Zaki, Ahmed Khairallah Mahdi, Gillian Lucinda Patman, Anna Whitehead, João Pais Maurício, Misti Vanette McCain, Despina Televantou, Sameh Abou-Beih, Erik Ramon-Gil, Robyn Watson, Charlotte Cox, Jack Leslie, Caroline Wilson, Olivier Govaere, John Lunec, Derek Austin Mann, Sirintra Nakjang, Fiona Oakley, Ruchi Shukla, Quentin Mark Anstee, Dina Tiniakos, Helen Louise Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) is rising, even in the absence of cirrhosis. We aimed to develop a murine model that would facilitate further understanding of
Externí odkaz:
https://doaj.org/article/c2466e2014fe4723915552556b300a2b
Autor:
Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11335 (2023)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically heterogeneous malignancy affecting older individuals. There are a number of current treatment options for CLL, including monoclonal antibodies, targeted drugs, chemotherapy, and diffe
Externí odkaz:
https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072
Autor:
Chiao-En Wu, Chiao-Ping Chen, Wen-Kuan Huang, Yi-Ru Pan, Erhan Aptullahoglu, Chun-Nan Yeh, John Lunec
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
KIT and PDGFRA play a major role in the oncogenic process in gastrointestinal stroma tumors (GIST) and small molecules have been employed with great success to target the KIT and PDGFRA pathways in this cancer. However, approximately 10% of patients
Externí odkaz:
https://doaj.org/article/72f0d93c72be43c786986b48217fa31c
Autor:
Vahinipriya Manoharan, Eric Hamilton Karunanayake, Kamani Hemamala Tennekoon, Sumadee De Silva, Ahamed Ilyas Ahamed Imthikab, Kanishka De Silva, Preethika Angunawela, Sameera Vishwakula, John Lunec
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its somatic mutations are
Externí odkaz:
https://doaj.org/article/cf4eed64e55e4dd2a9acae5fddb84a64
Autor:
Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2410 (2023)
Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhi
Externí odkaz:
https://doaj.org/article/6f9040da79ba4efb994e204cb3e28ff1
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods In
Externí odkaz:
https://doaj.org/article/d52f6c520f674aa0ad3934c0311b3100
Autor:
Bassier Zadran, Praveen Dhondurao Sudhindar, Daniel Wainwright, Yvonne Bury, Saimir Luli, Rachel Howarth, Misti Vanette McCain, Robyn Watson, Hannah Huet, Fanni Palinkas, Rolando Berlinguer-Palmini, John Casement, Derek A. Mann, Fiona Oakley, John Lunec, Helen Reeves, Geoffrey J. Faulkner, Ruchi Shukla
Publikováno v:
British Journal of Cancer. 128:1236-1248
Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the development of novel therapeutic strategies for the disease. We have previously demonstrated mutagenic consequences of Long-Interspersed Nuclear Element-1 (LINE