Zobrazeno 1 - 10
of 241
pro vyhledávání: '"John Lewicki"'
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Table S1: OMP-59R5 binding data as assessed by surface plasmon resonance (Biacore); Table S2. Histopathology of human pancreatic tumors; Table S3. Effect of anti-Notch2/3 antibody OMP-59R5 in combination with gemcitabine on growth of pancreatic xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf498724cd8f0c5646ff30984a2c9c4
https://doi.org/10.1158/1078-0432.22458093
https://doi.org/10.1158/1078-0432.22458093
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Purpose: The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been reported in several human tumor types. In this report, we describe the development of an antibody, OMP-59R5 (tarextumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f473b99c67334f0815470d792e6624
https://doi.org/10.1158/1078-0432.c.6523824.v1
https://doi.org/10.1158/1078-0432.c.6523824.v1
Autor:
Timothy Hoey, Diane M. Simeone, Austin Gurney, John Lewicki, Ann M. Kapoun, Xiaomei Song, V. Pete Yeung, Lucia Beviglia, Edward Kim, Jingjiang Wu, Mark Hynes, Marcus M. Fischer, Wan-Ching Yen
Purpose: We previously showed that targeting Delta-like ligand 4 (DLL4) in colon and breast tumors inhibited tumor growth and reduced tumor initiating cell frequency. In this report, we have extended these studies to pancreatic cancer and probed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad21b6e04b50ace89c553086d95fc0b
https://doi.org/10.1158/1078-0432.c.6522125.v1
https://doi.org/10.1158/1078-0432.c.6522125.v1
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Ann M. Kapoun, Chun Zhang, Min Wang, Breanna Wallace, Tracy Tang, Jalpa Shah, Aaron Sato, Rene Meisner, William R. Henner, Belinda Cancilla, Jennifer Cain, Christopher Bond, Fumiko Axelrod, Marcus M. Fischer, Wan-Ching Yen
Figure S1A. Binding affinities of OMP-59R5 to human (h) Notch1-4 receptors; Figure S1B. Alignment of the EGF repeats 10-15 of Notch2 and 9-14 of Notch3 from human (h), cynomolgus monkey (cyno), and mouse (m); Figure S2. Human NOTCH1, NOTCH2 and NOTCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f59c2b422fb81b4b510586fa10a689b
https://doi.org/10.1158/1078-0432.22458096.v1
https://doi.org/10.1158/1078-0432.22458096.v1
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Gilbert O'Young, Min Wang, Ann M. Kapoun, Wan-Ching Yen, Marcus Fischer
Supplementary Table 1, Materials and Methods, Figure Legends 1-4 from Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7506435bc1d5a29a73cd03b7586355
https://doi.org/10.1158/0008-5472.22389633.v1
https://doi.org/10.1158/0008-5472.22389633.v1
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Supplemental figure legends also include brief methods where appropriate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c92ef1c6e992c263c2057d6a7459f78
https://doi.org/10.1158/0008-5472.22410083.v1
https://doi.org/10.1158/0008-5472.22410083.v1
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Gilbert O'Young, Min Wang, Ann M. Kapoun, Wan-Ching Yen, Marcus Fischer
Supplementary Figure 1 from Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6553367358d8b1c6a123232f5e2e1ae
https://doi.org/10.1158/0008-5472.22389645
https://doi.org/10.1158/0008-5472.22389645
Autor:
Timothy Hoey, Austin Gurney, John Lewicki, Gilbert O'Young, Min Wang, Ann M. Kapoun, Wan-Ching Yen, Marcus Fischer
Supplementary Figure 3 from Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab124a6e63ad8292ad3f6770a7e6a64a
https://doi.org/10.1158/0008-5472.22389639.v1
https://doi.org/10.1158/0008-5472.22389639.v1
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a2dd884372d990c2aeb1d5180b91e4
https://doi.org/10.1158/0008-5472.c.6507911
https://doi.org/10.1158/0008-5472.c.6507911
Autor:
Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier
Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft models aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c673aa921f31eb42807e17eb99f932
https://doi.org/10.1158/0008-5472.22410080.v1
https://doi.org/10.1158/0008-5472.22410080.v1