Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John Lawrence Lamattina"'
Publikováno v:
Nature Reviews Drug Discovery. 14:147-149
The United States is facing two healthcare challenges — the equitable distribution of healthcare, and to support it, a sustainable biomedical research foundation for the discovery of new therapies and diagnostics. Although the US biomedical researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a56328f84a001db27a38f8020531f5
https://doi.org/10.1038/nrd4454-c1
https://doi.org/10.1038/nrd4454-c1
Autor:
John Lawrence Lamattina
Publikováno v:
Nature reviews. Drug discovery. 10(8)
Mergers and acquisitions in the pharmaceutical industry have substantially reduced the number of major companies over the past 15 years. The short-term business rationale for this extensive consolidation might have been reasonable, but at what cost t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7bd2c9788ac98f11d2153a08202d52
https://pubmed.ncbi.nlm.nih.gov/21804580
https://pubmed.ncbi.nlm.nih.gov/21804580
Publikováno v:
ChemInform. 23
2,3-Diaminopyridine reacts with cyclohexanone to form dihydro-4-azabenzimidazole-2-spirocyclohexane. Reaction of this intermediate with a variety of nucleophiles (e.g., water, phenylmercaptan, ethanol, dimethylamine, and diethylmalonate) in the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23d8397ee94b4f2116ae2775b9d97f2
https://doi.org/10.1002/chin.199228174
https://doi.org/10.1002/chin.199228174
Publikováno v:
Tetrahedron Letters. 32:6503-6506
2,3-Diaminopyridine reacts with cyclohexanone to form dihydro-4-azabenzimidazole-2-spirocyclohexane. Reaction of this intermediate with a variety of nucleophiles (e.g., water, phenylmercaptan, ethanol, dimethylamine, and diethylmalonate) in the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da795f78e45085ec8aff6fc431ecaae3
https://doi.org/10.1016/0040-4039(91)80204-j
https://doi.org/10.1016/0040-4039(91)80204-j
Publikováno v:
Journal of Medicinal Chemistry. 33:543-552
A series of 4-substituted 2-guanidinothiazoles has been found to inhibit the gastric proton-pump enzyme H+,K(+)-ATPase. In general, these compounds were reversible inhibitors of canine gastric H+,K(+)-ATPase, competitive at the K+ site, and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd00287b86c0c75c1ebc5a1f9c35136
https://doi.org/10.1021/jm00164a012
https://doi.org/10.1021/jm00164a012
Autor:
R. T. Suleske, John Lawrence Lamattina
Publikováno v:
Organic Syntheses
α-Amino acetals: 2,2-diethoxy-2-(4-pyridyl)ethylamine reactant: Hydroxylamine hydrochloride (25.0 g, 0.36 mol) reactant: 4-acetylpyridine (36.3 g, 0.30 mol) intermediate: E- and Z-isomers of 4-acetylpyridine oxime intermediate: E-4-acetylpyridine ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32ce03602becb258c97c6595d13390b
https://doi.org/10.1002/0471264180.os064.03
https://doi.org/10.1002/0471264180.os064.03
Autor:
John Lawrence Lamattina
Publikováno v:
Nature Medicine. 15:134-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52aa66235c9420e6c0ec386a6c06777b
https://doi.org/10.1038/nm0209-134
https://doi.org/10.1038/nm0209-134
Publikováno v:
ChemInform. 21
A series of 4-substituted 2-guanidinothiazoles has been found to inhibit the gastric proton-pump enzyme H+,K(+)-ATPase. In general, these compounds were reversible inhibitors of canine gastric H+,K(+)-ATPase, competitive at the K+ site, and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::778f36d6ed35f0932757bb8b5477e7ea
https://doi.org/10.1002/chin.199024153
https://doi.org/10.1002/chin.199024153
Publikováno v:
Tetrahedron Letters. 25:2957-2960
5-Acetyl-2-aminooxazole, upon treatment with amines in the presence of water, affords good yields of 1H-5-acetyl-2-substituted amino-imidazoles, along witn varying amounts of the corresponding 5-hydroxy-4-methyl-2-substituted aminopyrimidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363f0952497afb23dafff2d9d1106d44
https://doi.org/10.1016/s0040-4039(01)81336-8
https://doi.org/10.1016/s0040-4039(01)81336-8
Publikováno v:
Tetrahedron Letters. 24:2059-2062
The synthesis of p -nitrophenyl 3-bromo-2,2-diethoxypropionate, and its chemoselective reactions for the preparation of highly functionalized small molecules and also novel heterocycles, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b20910497eb868690e81bebdd88a9aee
https://doi.org/10.1016/s0040-4039(00)81843-2
https://doi.org/10.1016/s0040-4039(00)81843-2