Zobrazeno 1 - 10
of 49
pro vyhledávání: '"John LaFrancois"'
Autor:
Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum, Helen E. Scharman
Publikováno v:
bioRxiv
Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afa826b0a1b843f151b390317488238
https://europepmc.org/articles/PMC9882187/
https://europepmc.org/articles/PMC9882187/
Autor:
Cynthia A Lemere, Edward T Spooner, John LaFrancois, Brian Malester, Chica Mori, Jodi F Leverone, Yasuji Matsuoka, Jennie W Taylor, Ronald B DeMattos, David M Holtzman, John D Clements, Dennis J Selkoe, Karen E Duff
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 1, Pp 10-18 (2003)
Immunization with amyloid-β (Aβ) peptide in mouse models of Alzheimer’s disease has been reported to decrease cerebral Aβ levels and improve behavioral deficits. Several mechanisms have been proposed, including antibody-induced phagocytosis of A
Externí odkaz:
https://doaj.org/article/4f47f1c3bb8b443086efd9bb58489f0a
Autor:
Melissa W. VonDran, John LaFrancois, Victoria A. Padow, Wilma J. Friedman, Helen E. Scharfman, Teresa A. Milner, Barbara L. Hempstead
Publikováno v:
ASN Neuro, Vol 6 (2014)
ProNGF and p75 NTR are upregulated and induce cell death following status epilepticus (SE) in rats. However, less is known about the proneurotrophin response to SE in mice, a more genetically tractable species where mechanisms can be more readily dis
Externí odkaz:
https://doaj.org/article/389014102d7e489682524d9ac9776a0a
Autor:
Yasuji Matsuoka, Miquel Vila, Sarah Lincoln, Alison McCormack, Melanie Picciano, John LaFrancois, Xin Yu, Dennis Dickson, William J. Langston, Eileen McGowan, Matt Farrer, John Hardy, Karen Duff, Serge Przedborski, Donato A. Di Monte
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 3, Pp 535-539 (2001)
α-Synuclein has been identified as a major component of Lewy body inclusions, which are one of the pathologic hallmarks of idiopathic Parkinson's disease. Mutations in α-synuclein have been found to be responsible for rare familial cases of Parkins
Externí odkaz:
https://doaj.org/article/8e2813da0f1045a4bb948bd73bb938d0
Autor:
Lorenzo M. Refolo, Miguel A. Pappolla, Brian Malester, John LaFrancois, Tara Bryant-Thomas, Rong Wang, G.Stephen Tint, Kumar Sambamurti, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 4, Pp 321-331 (2000)
Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking cholesterol metabolism and the pathogenesis of AD. To test the hypothesis that amyloid β-p
Externí odkaz:
https://doaj.org/article/63c83aa9944e4c6aa4e4629a93bf4f54
Autor:
Helen E. Scharfman, Justin J. Botterill, Cátia M. Teixeira, John LaFrancois, K. Yaragudri Vinod, Kathleen J Gerencer
Publikováno v:
J Neurosci
The dentate gyrus (DG) of the hippocampus is important for cognition and behavior. However, the circuits underlying these functions are unclear. DG mossy cells (MCs) are potentially important because of their excitatory synapses on the primary cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963e66242a1678974af5ca19c65584e4
https://pubmed.ncbi.nlm.nih.gov/33472828
https://pubmed.ncbi.nlm.nih.gov/33472828
Autor:
Justin J. Botterill, Helen E. Scharfman, Yi-Ling Lu, John LaFrancois, Aine M. Duffy, Hannah L. Bernstein
Glutamatergic dentate gyrus (DG) mossy cells (MCs) innervate the primary cell type, granule cells (GCs), and GABAergic neurons which inhibit GCs. Prior studies suggest that the net effect of MCs is mainly to inhibit GCs, leading one to question why d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41ce52eb95ccd346bd9255134e2335d
https://doi.org/10.1101/2020.06.06.137844
https://doi.org/10.1101/2020.06.06.137844
Autor:
Yi-Ling Lu, Helen E. Scharfman, Swati Jain, Jillian N Moretto, John LaFrancois, Aine M. Duffy, Keria Bermudez-Hernandez
Publikováno v:
Brain Structure and Function. 222:3147-3161
The dentate gyrus (DG) principal cells are glutamatergic granule cells (GCs), and they are located in a compact cell layer. However, GCs are also present in the adjacent hilar region, but have been described in only a few studies. Therefore, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7533bbcdca2028288412d0d30c3b77
https://doi.org/10.1007/s00429-017-1391-5
https://doi.org/10.1007/s00429-017-1391-5
Autor:
Alexia Tiberi, Michael Cammer, Khalil Saadipour, Wilma J. Friedman, Moses V. Chao, John LaFrancois, Sylvia Lombardo, Francesca-Fang Liao, Noralyn B. Mañucat-Tan, Elena Grajales, Xin-Fu Zhou, Laura Ester Montroull, Helen E. Scharfman, Giueseppina Tesco, Paul M. Mathews
Publikováno v:
Mol Cell Neurosci
BACE1 is a transmembrane aspartic protease that cleaves various substrates and it is required for normal brain function. BACE1 expression is high during early development, but it is reduced in adulthood. Under conditions of stress and injury, BACE1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0ee3339c7ccab47d89d781728ce19c
https://europepmc.org/articles/PMC6993608/
https://europepmc.org/articles/PMC6993608/
Autor:
Helen E. Scharfman, Justin J. Botterill, Paige Leary, Hannah L. Bernstein, John LaFrancois, Yi-Ling Lu, Swati Jain, David Alcantara-Gonzalez
Publikováno v:
Epilepsy Currents
Cell Reports, Vol 29, Iss 9, Pp 2875-2889.e6 (2019)
Cell reports
Cell Reports, Vol 29, Iss 9, Pp 2875-2889.e6 (2019)
Cell reports
SUMMARY The sparse activity of hippocampal dentate gyrus (DG) granule cells (GCs) is thought to be critical for cognition and behavior, whereas excessive DG activity may contribute to disorders such as temporal lobe epilepsy (TLE). Glutamatergic moss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123bc2e12687d21a24d0951a98897f9e
https://pubmed.ncbi.nlm.nih.gov/32550841
https://pubmed.ncbi.nlm.nih.gov/32550841