Zobrazeno 1 - 10
of 31
pro vyhledávání: '"John L.A. Mitchell"'
Publikováno v:
Amino Acids. 33:291-297
Close structural analogs of spermidine and spermine, polyamine mimetics, are potential chemotheraputic agents as they depress cellular polyamines required for tumor growth. Specific mimetic analogs stimulate synthesis of the regulatory protein antizy
Publikováno v:
Biochemical Journal. 335:329-334
Mammalian cells become more susceptible to radiation-induced death and mutagenesis when restricted in their production of the natural polyamines putrescine, spermidine and spermine. The effects of polyamine deprivation are reversed by N-(2-mercaptoet
Autor:
John L.A. Mitchell, Chong Zheng, Narayan S. Hosmane, Bernard F. Spielvogel, Shoujian Li, Kamesh Vyakaranam, Geeta Rana
Publikováno v:
Inorganic Chemistry Communications. 5:522-524
The reaction of 1,4-diaminobutane (putrescine) with two molar equivalents of trimethylaminecyanoborane in anhydrous diethyl ether, produced an unprecedented cyanoborane species, 1,4-diaminobutyl-N,N′-bis(cyanoborane) (1), in 78% yield, via a Lewis-
Publikováno v:
Biochemical and Biophysical Research Communications. 187:443-447
alpha-Difluoromethylornithine is an effective inhibitor of polyamine biosynthesis because of its specificity for ornithine decarboxylase and the fact that its attachment to this enzyme is considered to be irreversible. We have found, however, that or
Publikováno v:
Biochemical and Biophysical Research Communications. 186:81-88
Two mammalian cell lines, rat hepatoma (HTC) and Chinese hamster ovary (CHO), were fed 10 to 50 microM spermidine while changes were monitored in intracellular polyamine levels and spermidine uptake activity. Normal feedback control preventing excess
Publikováno v:
Archives of Biochemistry and Biophysics. 290:143-152
Ornithine decarboxylase (ODC) is extremely unstable in mammalian cells. This unusual characteristic facilitates rapid fluctuations in the activity of this enzyme in response to variations in its biosynthesis. Unfortunately, very little is known about
Autor:
James H. Gillette, John L.A. Mitchell
Publikováno v:
Life Sciences. 48:1501-1510
The purpose of this study was to: (a) determine the temporal pattern of expression of ornithine decarboxylase (ODC), an established marker of cells engaged in proliferation and differentiation, during repair of traumatized skeletal muscle, and (b) ev
Autor:
Phil Tokarz, Laurence J. Marton, John L.A. Mitchell, T. K. Thane, Carrie L. Simkus, Aldonia Valasinas, Venodhar K. Reddy, Michelle M. Bonar, Benjamin Frydman
Publikováno v:
The Biochemical journal. 384(Pt 2)
Spermidine, spermine and putrescine are essential for mammalian cell growth, and there has been a pervasive effort to synthesize analogues of these polyamines that will disrupt their function and serve as tools to inhibit cell proliferation. Recently
Autor:
John L.A. Mitchell, Aviva Leyser, Benjamin Frydman, Jill S Bates, Michelle S Holtorff, Venodhar K. Reddy, Laurence J. Marton, Aldonia Valasinas
The polyamines spermidine and spermine and their diamine precursor putrescine are essential for mammalian cell growth and viability, and strategies are sought for reducing polyamine levels in order to inhibit cancer growth. Several structural analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb921c9c8d6efaab96a84c46e04279e
https://europepmc.org/articles/PMC1222781/
https://europepmc.org/articles/PMC1222781/
The induction of antizyme by spermidine and the resulting enhancement of ornithine decarboxylase (ODC) degradation have been well studied; however, little is known about the mechanism whereby elevated spermidine levels decrease synthesis of the polya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b4d5ad38760a87933c24381371ec3f
https://europepmc.org/articles/PMC1217994/
https://europepmc.org/articles/PMC1217994/