Výsledky vyhledávání - "John L. VanCott"

The Role of Interferons in Rotavirus Infections and Protection

Autor: Monica M. McNeal, Richard L. Ward, John L. VanCott, Anthony H.-C. Choi

Publikováno v: Journal of Interferon & Cytokine Research. 23:163-170

Type I and type II interferons (IFNs) play a critical role in control of a number of viral infections. To study whether altered and reduced functional capacities of type I and type II IFNs would affect rotavirus-induced diarrhea and viral replication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a25992ce268a794942f8b333a3160f1
https://doi.org/10.1089/107999003321532501

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Functional mapping of protective epitopes within the rotavirus VP6 protein in mice belonging to different haplotypes

Autor: Richard L. Ward, Mitali Basu, Anthony H.-C. Choi, Monica M. McNeal, Judy A. Bean, John D. Clements, John L. VanCott

Publikováno v: Vaccine. 21:761-767

We recently used "functional mapping" to locate protective epitopes in the carboxyl terminus (aa 197-397) of the VP6 protein (designated CD) of the EDIM strain of murine rotavirus [J. Virol. 74 (2000) 11574]. For this, H-2(d) BALB/c mice were given t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0dccbdc736c2eb7db886bfc12284ba5
https://doi.org/10.1016/s0264-410x(02)00595-9

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The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant

Autor: John D. Clements, Heather L. Davis, Mitali Basu, Anthony H.-C. Choi, Jason A. Flint, Judy A. Bean, Michael J. McCluskie, Monica M. McNeal, Nils Lycke, John L. VanCott, Richard L. Ward

Publikováno v: Vaccine. 20:1733-1740

Intranasal (i.n.) immunization of BALB/c mice with chimeric murine rotavirus EDIM (epizootic diarrhea of infant mice) VP6 and attenuated E. coli heat-labile toxin (LT), LT(R192G), stimulated99% protection against rotavirus shedding after EDIM challen

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https://doi.org/10.1016/s0264-410x(02)00043-9

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CD4 T Cells Are the Only Lymphocytes Needed To Protect Mice against Rotavirus Shedding after Intranasal Immunization with a Chimeric VP6 Protein and the Adjuvant LT(R192G)

Autor: Richard L. Ward, John D. Clements, John L. VanCott, Anthony H.-C. Choi, Jason A. Flint, Monica M. McNeal, Susan C. Stone, Matili Basu

Publikováno v: Journal of Virology. 76:560-568

Intranasal immunization of mice with a chimeric VP6 protein and the mucosal adjuvantEscherichia coliheat labile toxin LT(R192G) induces nearly complete protection against murine rotavirus (strain EDIM [epizootic diarrhea of infant mice virus]) sheddi

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https://doi.org/10.1128/jvi.76.2.560-568.2002

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Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice

Autor: Sara A. Bailey, Richard L. Ward, Monica M. McNeal, John L. VanCott, Jason A. Flint, Anthony H.-C. Choi

Publikováno v: European Journal of Immunology. 31:3380-3387

We examined the importance of T cell-independent B cell activity in the resolution of primary murine (EDIM) rotavirus infection in adult mice. We showed that Rag 1 (C57BL / 6 background) and Rag 2 (BALB / c background) knockout mice, which lack both

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https://doi.org/10.1002/1521-4141(200111)31:11<3380::aid-immu3380>3.0.co

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Human C-Reactive Protein Is Protective against FatalSalmonella entericaSerovar Typhimurium Infection in Transgenic Mice

Autor: John E. Volanakis, Alexander J. Szalai, William H. Benjamin, Jerry R. McGhee, John L. VanCott

Publikováno v: Infection and Immunity. 68:5652-5656

C-reactive protein (CRP) is an acute-phase protein with a well-known association with infection and other inflammatory conditions. We have shown that expression of human CRP by CRP transgenic (CRPtg) mice is protective against lethal infection byStre

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https://doi.org/10.1128/iai.68.10.5652-5656.2000

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Protective Immunity to Rotavirus Shedding in the Absence of Interleukin-6: Th1 Cells and Immunoglobulin A Develop Normally

Autor: Steffanie Sabbaj, Manuel A. Franco, Richard Murray, Baozhing Tang, Harry B. Greenberg, John L. VanCott, Jerry R. McGhee

Publikováno v: Journal of Virology. 74:5250-5256

We investigated whether interleukin-6 (IL-6) was required for the development of immunoglobulin A (IgA)- and T-helper 1 (Th1)-associated protective immune responses to rotavirus by using adult IL-6-deficient mice [BALB/c and (C57BL/6 × O1a)F2backgro

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https://doi.org/10.1128/jvi.74.11.5250-5256.2000

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Expression of Recombinant Enterotoxigenic Escherichia coli Colonization Factor Antigen I by Salmonella typhimurium Elicits a Biphasic T Helper Cell Response

Autor: Masafumi Yamamoto, David W. Pascual, John L. VanCott, Kohataro Fujihashi, Shaoguang Wu, Robert J. Powell, Stacy Hall, Jerry R. McGhee, Hiroshi Kiyono, Frederik W. van Ginkel, David M. Hone, Nancy Walters

Publikováno v: Infection and Immunity. 67:6249-6256

Protective immunity to enterotoxigenic Escherichia coli (ETEC) is antibody (Ab) dependent; however, oral immunization with purified ETEC fimbriae fails to elicit protective immunity as a consequence of antigenic alteration by the gastrointestinal (GI

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https://doi.org/10.1128/iai.67.12.6249-6256.1999

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Lack of Orally Induced Systemic Unresponsiveness in IFN-γ Knockout Mice

Autor: Mi-Na Kweon, Kohtaro Fujihashi, John L. VanCott, Kazuo Higuchi, Masafumi Yamamoto, Jerry R. McGhee, Hiroshi Kiyono

Publikováno v: The Journal of Immunology. 160:1687-1693

Splenic T cells isolated from BALB/c mice that had been mucosally tolerized by oral administration of 25 mg of OVA revealed selective increases in IFN-γ production with impaired levels of IL-2, IL-4, IL-5, and IL-10. These mice possessed reduced spl

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https://doi.org/10.4049/jimmunol.160.4.1687

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A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity

Autor: F W van Ginkel, Hiroshi Kiyono, Mi-Na Kweon, Kohtaro Fujihashi, Jerry R. McGhee, John L. VanCott, M Yamamoto

Publikováno v: Springer Seminars in Immunopathology. 18:477-494

Mucosal immune responses are strongly regulated by CD4+ T cells and their derived cytokines. In this regard, IFN-γ−/− mice (i.e., which lack Th1 and have elevated Th2 cells) showed strong mucosal Th2-type responses together with S-IgA production

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https://doi.org/10.1007/bf00824054

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