Zobrazeno 1 - 10
of 74
pro vyhledávání: '"John L. Trotter"'
Publikováno v:
Journal of Autoimmunity. 19:195-201
It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0eef2c3b8cbafff3722c6428955d1e
https://doi.org/10.1006/jaut.2002.0619
https://doi.org/10.1006/jaut.2002.0619
Publikováno v:
Journal of Neuroimmunology
(SJL/J × PL/J)F 1 mice immunized with myelin basic protein (MBP) develop an autoimmune demyelinating disease termed relapsing experimental allergic encephalomyelitis (rEAE). The acute stage of disease is mediated by CD4 + T cells specific for MBP am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23948786e86f3a614a495e9eaa577b7
http://europepmc.org/articles/PMC7172317
http://europepmc.org/articles/PMC7172317
Publikováno v:
Journal of Neuroimmunology. 112:1-14
There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de8a245ec3d51eb53dd664ca6d1c6a4
https://doi.org/10.1016/s0165-5728(00)00409-4
https://doi.org/10.1016/s0165-5728(00)00409-4
Autor:
Jacqueline M. Benson, Scott S. Stuckman, Karen L. Cox, Richard M. Wardrop, Ingrid E. Gienapp, Anne H. Cross, John L. Trotter, Caroline C. Whitacre
Publikováno v:
The Journal of Immunology. 162:6247-6254
Oral administration of a myelin component, myelin basic protein (MBP), induces immunological unresponsiveness to CNS Ags and ameliorates murine relapsing experimental autoimmune encephalomyelitis (REAE). However, a recent clinical trial in which mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeabb5357506a3f8b22867ec072f41cd
https://doi.org/10.4049/jimmunol.162.10.6247
https://doi.org/10.4049/jimmunol.162.10.6247
Autor:
Jacqueline A. Selvidge, T Mohanakumar, Clara M. Pelfrey, Kelly C Gushleff, John L. Trotter, Amy L Trotter, Henry F. McFarland
Publikováno v:
Journal of Neuroimmunology. 84:172-178
Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral blood of HLA-DR 15(2) MS patients were established which responded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c31c594279e9d432cd718a91156f18
https://doi.org/10.1016/s0165-5728(97)00260-9
https://doi.org/10.1016/s0165-5728(97)00260-9
Autor:
P J Perrin, John L. Trotter, Michael K. Racke, Joanne Lauber, Amy E. Lovett-Racke, Carl H. June
Publikováno v:
Journal of Clinical Investigation. 101:725-730
Although multiple sclerosis (MS) patients and healthy individuals have similar frequencies of myelin basic protein (MBP)-specific T cells, the activation state of these cells has not been well characterized. Therefore, we investigated the dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f35cbe3e9e4691a59b596ebe2f8a86
https://doi.org/10.1172/jci1528
https://doi.org/10.1172/jci1528
Autor:
Cheryl A. Damico, Xin Ting Fu, Henry F. McFarland, Clara M. Pelfrey, John L. Trotter, Anne H. Cross, Robert W. Karr
Publikováno v:
Journal of Neuroimmunology. 75:95-103
Mutation of the hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene in a T-cell is believed to be an indication that the T-cell has been activated and has proliferated in vivo. HPRT mutant T-cell lines were generated from peripheral blood mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c20f79c17d76d81dddda08633aad416
https://doi.org/10.1016/s0165-5728(97)00007-6
https://doi.org/10.1016/s0165-5728(97)00007-6
Publikováno v:
Neurology. 45:1971-1974
We previously reported elevations of interleukin 2 (IL-2) in the serum of patients with chronic progressive MS. Using gel chromatography, protein A sepharose affinity chromatography, and ELISAs for IL-2 and the IL-2 soluble receptor, we now demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cdd5dd8930bd05c68700b720e96c8d
https://doi.org/10.1212/wnl.45.11.1971
https://doi.org/10.1212/wnl.45.11.1971
Autor:
R. J. Evans, R.W. Karr, Thomas J. Girard, K. S. Giacoletto, John L. Trotter, Anne H. Cross, Robin F. Lin, Richard M. Keeling
Publikováno v:
Journal of Clinical Investigation. 95:2783-2789
T cell activation involves not only recognition of antigen presented by the MHC, but also nonspecific interactions termed "costimulation." The costimulatory molecules B7-1 and B7-2 are ligands on antigen-presenting cells for the CD28 and CTLA-4 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c372dcd62b6339101c4e0db9b68158
https://doi.org/10.1172/jci117982
https://doi.org/10.1172/jci117982
Publikováno v:
Annals of Neurology. 32:352-357
Some bacteria that are common human pathogens produce protein toxins that are potent activators of human T lymphocytes expressing certain types of T-cell receptors. In this study we examined the ability of staphylococcal toxins to stimulate human T l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee8b3b206f244b407adb27010c8187a
https://doi.org/10.1002/ana.410320308
https://doi.org/10.1002/ana.410320308