Zobrazeno 1 - 10
of 17
pro vyhledávání: '"John L. Pace"'
Autor:
John L Pace
Publikováno v:
Open Forum Infectious Diseases. 9
Background Fosfomycin (F) inhibits the first committed step of peptidoglycan biosynthesis catalyzed by the MurA enzyme which uses phosphoenolpyruvate as a substrate. Trimethoprim and sulfamethoxazole (TS) inhibit successive steps in folate biosynthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1560e12e12cda8aa36ca1a841795362
https://doi.org/10.1093/ofid/ofac492.728
https://doi.org/10.1093/ofid/ofac492.728
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1931-1934
The novel β-lactamase inhibitor avibactam is a potent inhibitor of class A, class C, and some class D enzymes. The in vitro antibacterial activity of the ceftazidime-avibactam combination was determined for a collection of Enterobacteriaceae clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90095900bf1fe876711d0682817838ac
https://doi.org/10.1128/aac.04218-14
https://doi.org/10.1128/aac.04218-14
Autor:
Kenneth Coleman, Premavathy Levasseur, Ludovic Lavallade, Christine Miossec, Anne-Marie Girard, John L. Pace
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6490-6495
Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been shown in vitro to inhibit class A, class C, and some class D β-lactamases. It is currently in phase 3 of clinical development in combination with ceftazidime. In this study, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6e36d634ec307a8e3af925593a7662
https://doi.org/10.1128/aac.03579-14
https://doi.org/10.1128/aac.03579-14
Autor:
John L. Pace, Kevin M. Krause, J. Kevin Judice, Burton G. Christensen, James B. Aggen, Daniel D. Long, Koné Kaniga, Martin S. Linsell, Sharath S. Hegde, Edmund J. Moran
Publikováno v:
The Journal of Antibiotics. 61:595-602
The design, synthesis and antibacterial activity of novel glycopeptide/beta-lactam heterodimers is reported. Employing a multivalent approach to drug discovery, vancomycin and cephalosporin synthons, A and B respectively, were chemically linked to yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2f187fdf5024f80b2cf483e377057f
https://doi.org/10.1038/ja.2008.79
https://doi.org/10.1038/ja.2008.79
Autor:
John L. Pace, Guang Yang
Publikováno v:
Biochemical Pharmacology. 71:968-980
The natural product glycopeptides vancomycin and teicoplanin have come to play a significant role in the therapy for Gram-positive bacterial infections. In particular vancomycin is the choice for empiric therapy of these infections primarily due to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaf999c62227aa409cd90cb4c8e7096
https://doi.org/10.1016/j.bcp.2005.12.005
https://doi.org/10.1016/j.bcp.2005.12.005
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:735-738
A series of lipidated vancomycin analogues 1 bearing disulfide bonds within their lipid chains was designed and synthesized to optimize their ADME profiles while retaining antibacterial potency. These compounds exhibited good activity against resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f4bd12ecd4cdc2d1ee10ae9739cbe
https://doi.org/10.1016/j.bmcl.2003.11.040
https://doi.org/10.1016/j.bmcl.2003.11.040
Autor:
Kevin M. Krause, Bettina Bazzini, J. Kevin Judice, Burton G. Christensen, Michael R. Leadbetter, Dane E. Karr, Sean G. Trapp, Elizabeth Soriano, Jeng-Pyng Shaw, Paul R. Fatheree, Kelly L. Quast, Lam Bernice M T, Martin S. Linsell, Matthew B. Nodwell, Terry X. Wu, John L. Pace, Jenny D. Villena, Stacy M. Adams
Publikováno v:
The Journal of Antibiotics. 57:326-336
Novel derivatives of N-decylaminoethylvancomycin (2), containing appended hydrophilic groups were synthesized and their antibacterial activity and ADME properties were evaluated. The compounds were prepared by reacting amines with the C-terminus (C-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6222c56379e55f3952bdb5a808e761
https://doi.org/10.7164/antibiotics.57.326
https://doi.org/10.7164/antibiotics.57.326
Autor:
John L. Pace, Kevin M. Krause, Lesley Farrington, Kelly L. Quast, Martin S. Linsell, Terry X. Wu, Deborah L. Higgins, J. Kevin Judice, Burton G. Christensen, John H. Griffin, Thomas E. Jenkins, Matthew B. Nodwell, Qi-Qi Chen
Publikováno v:
Journal of the American Chemical Society. 125:6517-6531
The design, synthesis, and in vitro microbiological analysis of an array of forty covalently linked vancomycin dimers are reported. This work was undertaken to systematically probe the impact of linkage orientation and linker length on biological act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4591a57fa166ab6eff6405828f077be7
https://doi.org/10.1021/ja021273s
https://doi.org/10.1021/ja021273s
Autor:
Jessica A. Schuyler, Stacy M. Adams, Dmitri Debabov, Ronald McMillan, Daina Zeng, John L. Pace, Theresa L. Hartsell, Raul J. Cano
Publikováno v:
Cold Spring Harbor Perspectives in Medicine. 6:a026989
The glycopeptide antimicrobials are a group of natural product and semisynthetic glycosylated peptides that show antibacterial activity against Gram-positive organisms through inhibition of cell-wall synthesis. This is achieved primarily through bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdf3d1ba1e2eb70e10cecb20f36c845
https://doi.org/10.1101/cshperspect.a026989
https://doi.org/10.1101/cshperspect.a026989
Autor:
Sharath S. Hegde, Matthew B. Nodwell, Martin S. Linsell, Kevin M. Krause, Paul R. Fatheree, Daniel Marquess, David W. Green, John L. Pace, James B. Aggen, Koné Kaniga, Sean G. Trapp, Jason P. Chinn, Seok-Ki Choi, J. Kevin Judice, Burton G. Christensen, Michael R. Leadbetter, S. Derek Turner, Daniel D. Long, Edmund J. Moran
Publikováno v:
The Journal of antibiotics. 61(10)
Further investigations towards novel glycopeptide/beta-lactam heterodimers are reported. Employing a multivalent approach to drug discovery, vancomycin and cephalosporin synthons, 4, 2, 5 and 10, 18, 25 respectively, were chemically linked to yield h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f61df8c63b20c8ea01fd57019b7448c
https://pubmed.ncbi.nlm.nih.gov/19168974
https://pubmed.ncbi.nlm.nih.gov/19168974