Zobrazeno 1 - 10
of 622
pro vyhledávání: '"John L. Markley"'
Publikováno v:
Journal of Structural Biology: X, Vol 6, Iss , Pp 100073- (2022)
NMR spectroscopy provides structural and functional information about biomolecules and their complexes. The complexity of these systems can make the NMR data difficult to interpret, particularly for newer users of NMR technology, who may have limited
Externí odkaz:
https://doaj.org/article/16c7092582fc45ff854449c949e89b65
Autor:
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 104-115 (2020)
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)
Externí odkaz:
https://doaj.org/article/373be060f02e4b3cb3c3da481b1aace9
Autor:
Valeriu Bortnov, Marco Tonelli, Woonghee Lee, Ziqing Lin, Douglas S. Annis, Omar N. Demerdash, Alex Bateman, Julie C. Mitchell, Ying Ge, John L. Markley, Deane F. Mosher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute fu
Externí odkaz:
https://doaj.org/article/a6990a6e878247dcb11d2880bc0fb764
Publikováno v:
Membranes, Vol 12, Iss 9, p 834 (2022)
The heightened dipolar interactions in solids render solid-state NMR (ssNMR) spectra more difficult to interpret than solution NMR spectra. On the other hand, ssNMR does not suffer from severe molecular weight limitations like solution NMR. In recent
Externí odkaz:
https://doaj.org/article/85fe0771a87b411995bbcfa665b513c2
Autor:
Chiara M. Evans, Margaret Phillips, Kiera L. Malone, Marco Tonelli, Gabriel Cornilescu, Claudia Cornilescu, Simon J. Holton, Mátyás Gorjánácz, Liping Wang, Samuel Carlson, Jamie C. Gay, Jay C. Nix, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9128 (2021)
The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four α-helices. ATAD2 functions as a co-activator of the androgen and estrogen receptors as well as the MYC and E2F tran
Externí odkaz:
https://doaj.org/article/c130bf1e716a48bfbb4258fbbdf20d6b
Autor:
Brian R. Barnett, Fariba Fathi, Paulo Falco Cobra, Sue Y. Yi, Jacqueline M. Anderson, Hamid R. Eghbalnia, John L. Markley, John-Paul J. Yu
Publikováno v:
Metabolites, Vol 10, Iss 2, p 79 (2020)
Synaptosomes are isolated nerve terminals that contain synaptic components, including neurotransmitters, metabolites, adhesion/fusion proteins, and nerve terminal receptors. The essential role of synaptosomes in neurotransmission has stimulated keen
Externí odkaz:
https://doaj.org/article/493af966793b445681303c63c24cf9fd
Autor:
Chelcie H. Eller, Tzu-Yuan Chao, Kiran K. Singarapu, Ouathek Ouerfelli, Guangbin Yang, John L. Markley, Samuel J. Danishefsky, Ronald T. Raines
Publikováno v:
ACS Central Science, Vol 1, Iss 4, Pp 181-190 (2015)
Externí odkaz:
https://doaj.org/article/1105c7e6464745a6b61e86682671d8b0
Autor:
Erik K. Larsen, Cristina Olivieri, Caitlin Walker, Manu V.S., Jiali Gao, David A. Bernlohr, Marco Tonelli, John L. Markley, Gianluigi Veglia
Publikováno v:
Molecules, Vol 23, Iss 8, p 1937 (2018)
Protein-protein interactions (PPIs) regulate a plethora of cellular processes and NMR spectroscopy has been a leading technique for characterizing them at the atomic resolution. Technically, however, PPIs characterization has been challenging due to
Externí odkaz:
https://doaj.org/article/9f27098cd6fd4467b12bbfd4bc44a176
Autor:
Kai Cai, John L. Markley
Publikováno v:
Molecules, Vol 23, Iss 9, p 2213 (2018)
Iron-sulfur (Fe-S) clusters, the ubiquitous protein cofactors found in all kingdoms of life, perform a myriad of functions including nitrogen fixation, ribosome assembly, DNA repair, mitochondrial respiration, and metabolite catabolism. The biogenesi
Externí odkaz:
https://doaj.org/article/88b3968ffca149268246f4fa1225ade7
Autor:
Fariba Fathi, Antonio Brun, Katherine H. Rott, Paulo Falco Cobra, Marco Tonelli, Hamid R. Eghbalnia, Enrique Caviedes-Vidal, William H. Karasov, John L. Markley
Publikováno v:
Metabolites, Vol 7, Iss 4, p 61 (2017)
Metabolites present in liver provide important clues regarding the physiological state of an organism. The aim of this work was to evaluate a protocol for high-throughput NMR-based analysis of polar and non-polar metabolites from a small quantity of
Externí odkaz:
https://doaj.org/article/10ae90776d904005adf1c925ff89f333