Zobrazeno 1 - 10
of 169
pro vyhledávání: '"John L. Magnani"'
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/3d33aa4280c444ba8044bba083223d23
Autor:
Valerie Barbier, Johanna Erbani, Corrine Fiveash, Julie M. Davies, Joshua Tay, Michael R. Tallack, Jessica Lowe, John L. Magnani, Diwakar R. Pattabiraman, Andrew C. Perkins, Jessica Lisle, John E. J. Rasko, Jean-Pierre Levesque, Ingrid G. Winkler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibit
Externí odkaz:
https://doaj.org/article/7dde84bbf79f4a748ecf6d1fab0d7161
Autor:
Sumana Devata, Dana E. Angelini, Susan Blackburn, Angela Hawley, Daniel D. Myers, Jordan K. Schaefer, Martina Hemmer, John L. Magnani, Helen M. Thackray, Thomas W. Wakefield, Suman L. Sood
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 2, Pp 193-204 (2020)
Abstract Background There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune cells to initiate the co
Externí odkaz:
https://doaj.org/article/154592a33fc54abd95ad195a38766fb3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophils are essential to protect the host against invading pathogens but can promote disease progression in sickle cell disease (SCD) by becoming adherent to inflamed microvascular networks in peripheral tissue throughout the body. During the inf
Externí odkaz:
https://doaj.org/article/da729016f4884c87b849c6f33ad0f150
Autor:
Beat Ernst, Thomas Peters, Reinhold Oehrlein, Keith E. Norman, John L. Magnani, Wolfgang Jahnke, Beatrice Wagner, Christian Müller, Sébastien Marti, Zorica Dragic, Hartmuth C. Kolb
Publikováno v:
CHIMIA, Vol 55, Iss 4 (2001)
Selectin-mediated recruitment of leukocytes plays a crucial role in a number of diseases and pathological situations, for example in inflammation, reperfusion injury, rheumatoid arthritis and respiratory diseases. Substantial research efforts are dir
Externí odkaz:
https://doaj.org/article/b68097d494ed4343928f824c77805fce
Autor:
Carlton D. Dampier, Marilyn Jo Telen, Ted Wun, R. Clark Brown, Payal Desai, Fuad El Rassi, Beng Fuh, Julie Kanter, Yves Pastore, Jennifer Rothman, James G. Taylor, David Readett, Krupa M. Sivamurthy, Brinda Tammara, Li-Jung Tseng, Jay Nelson Lozier, Helen Thackray, John L. Magnani, Kathryn L. Hassell
Publikováno v:
Blood. 141:168-179
The efficacy and safety of rivipansel, a predominantly E-selectin antagonist, were studied in a phase 3, randomized, controlled trial for vaso-occlusive crisis (VOC) requiring hospitalization (RESET). A total of 345 subjects (204 adults and 141 child
Autor:
Yannan Jia, Weiguo Zhang, Mahesh Basyal, Kyung Hee Chang, Lauren Ostermann, Jared K. Burks, Charlie Ly, Hong Mu-Mosley, Qi Zhang, Xin Han, William E. Fogler, John L. Magnani, Arnaud Lesegretain, Anna A. Zal, Tomasz Zal, Michael Andreeff
Publikováno v:
Leukemia.
Autor:
Daniel D. Myers, William E. Fogler, John L. Magnani, Thomas W. Wakefield, Suman L. Sood, Angela E. Hawley, Robert E. Sigler, Laura Durham, Michael Holinstat, Veronica Dunivant, Garrett Reynolds, Kiley Crego, Reheman Adili, Patrick A Lester, Junjie Ning
Publikováno v:
Journal of Vascular Surgery: Venous and Lymphatic Disorders. 10:211-220
Background This study evaluated E-selectin inhibition with GMI-1271 (Uproleselan [GMI]) alone and in combination with the standard of care low-molecular-weight heparin (LMWH) to improve vein recanalization, decrease vein wall inflammation and protect
Autor:
Kyung Hee Chang, Weiguo Zhang, Muharrem Muftuoglu, Mahesh Basyal, Lauren Ostermann, Po Yee Mak, Yannan Jia, Wenjing Tao, William E. Fogler, John L. Magnani, Bing Z. Carter, Michael Andreeff
Publikováno v:
SSRN Electronic Journal.
Autor:
Garrett Reynolds, Zoe Zimmerman, Michael Holinstat, Reheman Adili, Patrick A Lester, Suman L. Sood, Daniel D. Myers, Robert E. Sigler, Kiley Crego, Angela E. Hawley, Laura Durham, Veronica Dunivant, William E. Fogler, Thomas W. Wakefield, John L. Magnani
Publikováno v:
Journal of Vascular Surgery: Venous and Lymphatic Disorders. 8:268-278
There is an inter-relationship between thrombosis and inflammation. Previously, we have shown the importance of P-selectin in thrombogenesis and thrombus resolution in many preclinical animal models. The role of E-selectin has been explored in rodent