Zobrazeno 1 - 10
of 63
pro vyhledávání: '"John L. Haylor"'
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137321 (2015)
Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial
Externí odkaz:
https://doaj.org/article/78aae3ec8ecf43a9a8df700cd4e7221c
Autor:
Badri Man Shrestha, John L. Haylor
Publikováno v:
Experimental and Clinical Transplantation. 17:202-209
OBJECTIVES Experimental rat models of renal transplant have played a pivotal role in renal transplant research. Both intraoperative and postoperative complications during donor nephrectomy and implantation in the recipient can be associated with sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dceabf2d25315ded6bc6dd866962eb
https://doi.org/10.6002/ect.2017.0072
https://doi.org/10.6002/ect.2017.0072
Autor:
Badri Man Shrestha, John L. Haylor
Publikováno v:
Experimental and Clinical Transplantation. 17:18-25
OBJECTIVES Rat models of renal transplant are used to investigate immunologic processes and responses to therapeutic agents before their translation into routine clinical practice. In this study, we have described details of rat surgical anatomy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebe7a6d663b171f509e1b5a637cccbf
https://doi.org/10.6002/ect.2017.0061
https://doi.org/10.6002/ect.2017.0061
Publikováno v:
Progress in Transplantation. 25:64-76
The present state of success in kidney transplantation, including its benefits to patients with end-stage renal failure, was achieved through relentless research, both in experimental animal models and human volunteers. Kidney transplantation has evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ece5b338e5217aae53fd7423593d78
https://doi.org/10.7182/pit2015789
https://doi.org/10.7182/pit2015789
Publikováno v:
Veterinary Pathology. 52:513-523
Chronic kidney disease is a major cause of morbidity and mortality in cats. Transglutaminase 2 (TG2) is a calcium-dependent enzyme proposed to mediate tubulointerstitial fibrosis in the kidney by cross-linking collagen fibrils. Postmortem kidney tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3952b4e86715c48a5410c86667fa4a
https://doi.org/10.1177/0300985814542811
https://doi.org/10.1177/0300985814542811
Publikováno v:
Transplant International. 25:792-800
We have previously reported de novo lymphangiogenesis in human renal allograft nephrectomy specimens that exhibited interstitial fibrosis and tubular atrophy (IFTA). This study examined whether a similar pathology developed in an experimental model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b9e12d096c66b207727bdf5dd77b15
https://doi.org/10.1111/j.1432-2277.2012.01482.x
https://doi.org/10.1111/j.1432-2277.2012.01482.x
Autor:
David Slater, Faith Nutter, Jean-Marc Idée, Gaëlle Jestin, Melissa E. Vickers, Anne Dencausse, John L. Haylor, Sameh K. Morcos
Publikováno v:
Investigative Radiology. 45:507-512
Objectives: The development of nephrogenic systemic fibrosis (NSF) following MRI contrast examination has been associated with gadolinium (Gd) toxicity. Animal models should show the key features of NSF in man where, the only immutable epidemiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe629b62bfa1123c06bbddaa2f5de61a
https://doi.org/10.1097/rli.0b013e3181eb51f2
https://doi.org/10.1097/rli.0b013e3181eb51f2
Publikováno v:
The American Journal of Pathology. 175:1493-1503
Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The kidney disease phenotype is primarily characterized by cyst formation, but there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204dfc0edd825b1c4f2c1b4c40926106
https://doi.org/10.2353/ajpath.2009.090227
https://doi.org/10.2353/ajpath.2009.090227
Autor:
John L. Haylor, Timothy S. Johnson, Meguid El Nahas, Linghong Huang, Martin Griffin, Richard A. Jones, Marie Fisher
Publikováno v:
Matrix Biology. 28:20-31
The up-regulation and trafficking of tissue transglutaminase (TG2) by tubular epithelial cells (TEC) has been implicated in the development of kidney scarring. TG2 catalyses the crosslinking of proteins via the formation of highly stable epsilon(gamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cf2760a1b95c4dfbaae88e18719596
https://doi.org/10.1016/j.matbio.2008.10.003
https://doi.org/10.1016/j.matbio.2008.10.003
Publikováno v:
The Journal of Toxicological Sciences. 33:367-370
(-)-Epigallocatechin 3-O-gallate (EGCG), a major catechin in green tea, suppresses renal failure in animals, and inhibits the growth of mesangial cells and opossum kidney proximal tubular cells. In addition, gallic acid, a structural constituent of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e9572bc2ee21bee278743f295cf802
https://doi.org/10.2131/jts.33.367
https://doi.org/10.2131/jts.33.367