Zobrazeno 1 - 10 of 69 pro vyhledávání: '"John L. Gollan"'
2
Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-α signaling
Autor: Elizabeth Klein, Duygu Dee Harrison-Findik, John J. Evans, John L. Gollan
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G112-G118
Alcohol downregulates hepcidin expression in the liver leading to an increase in intestinal iron transport and liver iron storage. We have previously demonstrated that alcohol-mediated oxidative stress is involved in the inhibition of hepcidin transc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7198233bc5af1c73862e74609206ec76
https://doi.org/10.1152/ajpgi.90550.2008
Zobrazit plný text záznamu
3
Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
Autor: Callie Crist, Duygu Dee Harrison-Findik, John J. Evans, John L. Gollan, Nikolai A. Timchenko, Elizabeth Klein
Publikováno v: Hepatology. 46:1979-1985
Alcohol reduces and iron increases liver hepcidin synthesis. This study investigates the interaction of alcohol and iron in the regulation of hepcidin messenger RNA (mRNA) expression in animal models. Mice were administered 10% ethanol for 7 days aft
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09767a70625af2a40fce10300ce204d5
https://doi.org/10.1002/hep.21895
Zobrazit plný text záznamu
4
Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression
Autor: Nikolai A. Timchenko, Dahn L. Clemens, John L. Gollan, Hasan Kulaksiz, Duygu Dee Harrison-Findik, Denise Schafer, Kostas Pantopoulos, Evelyn Fein, Elizabeth Klein, Billy Andriopoulos
Publikováno v: Journal of Biological Chemistry. 281:22974-22982
Patients with alcoholic liver disease frequently exhibit iron overload in association with increased hepatic fibrosis. Even moderate alcohol consumption elevates body iron stores; however, the underlying molecular mechanisms are unknown. Hepcidin, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a3405d1fc390364eef145378a4817c
https://doi.org/10.1074/jbc.m602098200
Zobrazit plný text záznamu
5
Emerging Therapeutics for Chronic Hepatitis B
Autor: John L. Gollan, Mark E. Mailliard
Publikováno v: Annual Review of Medicine. 57:155-166
Hepatitis B is a global health problem. Patients with chronic hepatitis B (CHB) carry a significant risk to eventually develop cirrhotic liver disease. Recent therapeutic advances against CHB offer excellent potential for long-term suppression of hep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706316c3d02c41e6e23dad13864778f5
https://doi.org/10.1146/annurev.med.57.121304.131422
Zobrazit plný text záznamu
6
Recent developments in the pathophysiology of cholestasis
Autor: John L. Gollan, Grant F. Hutchins
Publikováno v: Clinics in Liver Disease. 8:1-26
The past decade has brought tremendous growth in the under-standing of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb38e302a94f74fde50736912b227409
https://doi.org/10.1016/s1089-3261(03)00125-9
Zobrazit plný text záznamu
7
Cholestasis of sepsis
Autor: Mark E Mailliard, John L Gollan, Richard K Gilroy
Publikováno v: Best Practice & Research Clinical Gastroenterology. 17:357-367
Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4b45a532cc2e13ff576a85f7b21727c
https://doi.org/10.1016/s1521-6918(03)00027-1
Zobrazit plný text záznamu
8
Metabolic liver disease in the young adult
Autor: Mark E. Mailliard, John L. Gollan
Publikováno v: Best Practice & Research Clinical Gastroenterology. 17:307-322
This chapter describes the gene mutations, phenotypes, diagnosis and therapy of the common metabolic liver diseases in young adulthood: haemochromatosis, Wilson disease, α 1 -anti-trypsin deficiency and cystic fibrosis. The remarkable variability of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c85be9f2bb0081750db83b945d9f673
https://doi.org/10.1016/s1521-6918(02)00148-8
Zobrazit plný text záznamu
10
Primary Biliary Cirrhosis
Autor: Leslie B. Lilly, John L. Gollan, Carl L. Berg
Publikováno v: Clinical Immunotherapeutics. 5:420-437
Primary biliary cirrhosis is a well-characterised disorder of autoimmune origin whose exact pathogenesis remains poorly understood. Population studies have suggested an association with human leucocyte antigen (HLA)-DR8, and patients are universally
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::446909367a5d632d1a8b69656abeb22d
https://doi.org/10.1007/bf03259338
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje