Zobrazeno 1 - 10
of 35
pro vyhledávání: '"John L. Dzuris"'
Autor:
Melinda Y. Hardy, Gautam Goel, Amy K. Russell, Swee Lin G. Chen Yi Mei, Gregor J. E. Brown, Suyue Wang, Evan Szymczak, Ruan Zhang, Kaela E. Goldstein, Kristin M. Neff, Leslie J. Williams, Kenneth E. Truitt, John L. Dzuris, Jason A. Tye-Din, Robert P. Anderson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Improved blood tests assessing the functional status of rare gluten-specific CD4+ T cells are needed to effectively monitor experimental therapies for coeliac disease (CD). Our aim was to develop a simple, but highly sensitive cytokine release assay
Externí odkaz:
https://doaj.org/article/44d464c9335848cca3a691f2d2a3caa2
Autor:
A. James M. Daveson, Hooi C. Ee, Jane M. Andrews, Timothy King, Kaela E. Goldstein, John L. Dzuris, James A. MacDougall, Leslie J. Williams, Anita Treohan, Michael P. Cooreman, Robert P. Anderson
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 78-90 (2017)
Background: Nexvax2® is a novel, peptide-based, epitope-specific immunotherapy intended to be administered by regular injections at dose levels that increase the threshold for clinical reactivity to natural exposure to gluten and ultimately restore
Externí odkaz:
https://doaj.org/article/dddffba30bd84072b2c97201e1ba0294
Autor:
David A. Katzka, Vandana Nehra, Amanda K. Cartee, Rok Seon Choung, Eric V. Marietta, Joseph A. Murray, Robert P. Anderson, Chadrick A. Hinson, Madhusudan Grover, Katherine S. King, John L. Dzuris, Suyue Wang, Carol T. Van Dyke
Publikováno v:
American Journal of Gastroenterology. 117:319-326
Introduction Treated patients with celiac disease (CeD) and nonceliac gluten sensitivity (NCGS) report acute, transient, incompletely understood symptoms after suspected gluten exposure. To determine whether (i) blinded gluten exposure induces sympto
Autor:
Knut E.A. Lundin, Ludvig M. Sollid, Robert P. Anderson, Kaela E. Goldstein, Suyue Wang, Jason A. Tye-Din, Gautam Goel, John L. Dzuris, Vikas Kumar Sarna, Amy K. Russell, Gry Irene Skodje, Leslie J. Williams
Publikováno v:
United European Gastroenterology Journal. 8:108-118
BACKGROUND: Diagnosing coeliac disease (CD) in patients on a gluten-free diet (GFD) is difficult. Ingesting gluten elevates circulating interleukin (IL)-2, IL-8 and IL-10 in CD patients on a GFD. OBJECTIVE: We tested whether cytokine release after gl
Autor:
Kenneth E. Truitt, Kristin M Neff, Gautam Goel, A. James M. Daveson, Robert P. Anderson, Kaela E. Goldstein, Sarah Acaster, James MacDougall, Jason A. Tye-Din, John L. Dzuris, Hooi C. Ee
Publikováno v:
Alimentary Pharmacology & Therapeutics. 50:901-910
Background: Coeliac disease patients on a gluten-free diet experience reactions to gluten, but these are not well characterised or understood. Systemic cytokine release was recently linked to reactivation of gluten immunity in coeliac disease. Aim: T
Autor:
Gautam Goel, Suyue Wang, Robert P. Anderson, Kaela E. Goldstein, Amy K. Russell, Kristin M Neff, Kenneth E. Truitt, Jason A. Tye-Din, Leslie J. Williams, Ruan Zhang, Evan Szymczak, John L. Dzuris, Melinda Y Hardy
Publikováno v:
Clin Exp Immunol
Summary Whole blood cytokine release assays (CRA) assessing cellular immunity to gluten could simplify the diagnosis and monitoring of coeliac disease (CD). We aimed to determine the effectiveness of electrochemiluminescence CRA to detect responses t
Autor:
Kenneth E. Truitt, Robert P. Anderson, Jason A. Tye-Din, Kristin M Neff, Evan Szymczak, Suyue Wang, John L. Dzuris, Leila Williams, C E Hooi, A J M Daveson, Gautam Goel
Publikováno v:
Clin Exp Immunol
Summary Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten supp
Autor:
Ludvig M. Sollid, Bana Jabri, Robert P. Anderson, Kaela E. Goldstein, Vikas Kumar Sarna, Suyue Wang, Jason A. Tye-Din, Gautam Goel, Cezary Ciszewski, Shuo-Wang Qiao, Leslie J. Williams, Ramnik J. Xavier, Knut E.A. Lundin, John L. Dzuris, Toufic Mayassi, Amy K. Russell
Publikováno v:
Science Advances
Acute gastrointestinal symptoms induced by gluten, within 4 hours, are mediated by reactivation of antigen-specific memory T cells.
Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Wit
Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Wit
Autor:
Robert P. Anderson, Kaela E. Goldstein, A. James M. Daveson, Suyue Wang, Gautam Goel, Ludvig M. Sollid, Tim King, Markku Mäki, Janakan Krishnarajah, Alina Popp, John L. Dzuris, Roger Epstein, Adam Girardin, Charles F. Barish, Timothy P. Kinney, Jane M. Andrews, Juha Taavela, Jason A. Tye-Din, Bana Jabri, Gregor J. Brown, Philip B. Miner, Ramnik J. Xavier, Leslie J. Williams, Patrick Griffin, Alessandro Sette, John Sidney, Ronald Fogel, Richard Krause
Publikováno v:
The lancet. Gastroenterologyhepatology. 2(7)
Summary Background A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three pept
Autor:
Robert P. Anderson, Suyue Wang, Chadrick A. Hinson, Rok Seon Choung, Eric V. Marietta, Carol T. Van Dyke, David A. Katzka, Vandana Nehra, Joseph A. Murray, Amanda K. Cartee, Madhusudan Grover, John L. Dzuris, Katherine S. King
Publikováno v:
Gastroenterology. 156:S-177