Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John L. Blakemore"'
Autor:
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HD
Externí odkaz:
https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
Autor:
Huan Tao, Patricia G. Yancey, Vladimir R. Babaev, John L. Blakemore, Youmin Zhang, Lei Ding, Sergio Fazio, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1449-1460 (2015)
Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE- and LDLR-deficient mice revealed that hematopoietic scavenger receptor class B type I (SR-BI
Externí odkaz:
https://doaj.org/article/9b17830fd5914ea284743f5ba4a14312
Autor:
Hagai Tavori, Yan Ru Su, Patricia G. Yancey, Ilaria Giunzioni, Ashley J. Wilhelm, John L. Blakemore, Manal Zabalawi, MacRae F. Linton, Mary G. Sorci-Thomas, Sergio Fazio
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 635-643 (2015)
Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main protein, apoAI, are acceptors of excess cholesterol from macrophages; this process inhibits tiss
Externí odkaz:
https://doaj.org/article/4b91fe2d8a4a4c96a386e6e5b802fffd
Autor:
Patricia G. Yancey, Huan Tao, Jiansheng Huang, Lei Ding, Venkataraman Amarnath, Fei Ye, John L. Blakemore, John A. Oates, Sean S. Davies, L. Jackson Roberts, Valery Yermalitsky, Irene Zagol-Ikapitte, MacRae F. Linton, Olivier Boutaud, Youmin Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Lipid peroxidation generates reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that covalently modify proteins. Humans with familial hypercholesterolemia (FH) have increased lipoprotein dicarbonyl adducts and dysfuncti
Autor:
Irene Zagol-Ikapitte, Huan Tao, Lei Ding, John A. Oates, Valery Yermalitsky, John L. Blakemore, Olivier Boutaud, Sean S. Davies, Jiansheng Huang, Venkataraman Amarnath, Patricia G. Yancey, L. Jackson Roberts, MacRae F. Linton, Youmin Zhang
The pathogenesis of atherosclerosis may be accelerated by oxidative stress, which produces lipid peroxidation. Among the products of lipid peroxidation are highly reactive dicarbonyls including isolevuglandins (IsoLGs) and malondialdehyde (MDA) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fe5c561ed163416c08fa76513497ec
https://doi.org/10.1101/524884
https://doi.org/10.1101/524884
Autor:
Manal Zabalawi, Mary G. Sorci-Thomas, Sergio Fazio, Hagai Tavori, Yan Ru Su, John L. Blakemore, MacRae F. Linton, Patricia G. Yancey, Ashley J. Wilhelm, Ilaria Giunzioni
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 635-643 (2015)
Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main protein, apoAI, are acceptors of excess cholesterol from macrophages; this process inhibits tiss
Autor:
W. Gray Jerome, Youmin Zhang, Huan Tao, Kasey C. Vickers, MacRae F. Linton, Jonathan D. Brown, John L. Blakemore, Lei Ding, Patricia G. Yancey
Publikováno v:
J Clin Invest
Autophagy modulates lipid turnover, cell survival, inflammation, and atherogenesis. Scavenger receptor class B type I (SR-BI) plays a crucial role in lysosome function. Here, we demonstrate that SR-BI regulates autophagy in atherosclerosis. SR-BI del
Autor:
Lei Ding, Patricia G. Yancey, Sergio Fazio, Daping Fan, MacRae F. Linton, Hagai Tavori, John L. Blakemore
Publikováno v:
Circulation. 127:2403-2413
Background— Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulates low-density lipoprotein (LDL) receptor (LDLR) degradation, thus influencing serum cholesterol levels. However, dysfunctional LDLR causes hypercholesterolemia without affect
Autor:
Huan Tao, MacRae F. Linton, Kasey C. Vickers, Youmin Zhang, Lei Ding, Patricia G. Yancey, W. Gray Jerome, John L. Blakemore
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Background: Autophagy modulates vascular cell lipid metabolism, lipid droplet turnover, foam cell formation, cell survival and death, and inflammation. Scavenger receptor class B type I (SR-BI) deficiency causes impaired lysosome function in macropha
Autor:
Patricia G. Yancey, John L. Blakemore, Sergio Fazio, L. Jackson Roberts, Youmin Zhang, Huan Tao, Sean S. Davies, Lei Ding, Jiansheng Huang, MacRae F. Linton, John A. Oates, Kasey C. Vickers
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Background: Dysfunctional high density lipoprotein (HDL) is linked to the pathogenesis of atherosclerosis and cardiovascular events. Lipid peroxidation products have been reported to enhance atherogenesis and compromise HDL atheroprotective functions