Zobrazeno 1 - 10
of 149
pro vyhledávání: '"John L. Bixby"'
Autor:
Francesco De Virgiliis, Thomas H. Hutson, Ilaria Palmisano, Sarah Amachree, Jian Miao, Luming Zhou, Rositsa Todorova, Richard Thompson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Ilka Wittig, Ajay M. Shah, Simone Di Giovanni
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Pre conditioning injury or environmental enrichment have been shown to promote axon regeneration. Here the authors show that environmental enrichment, combined with preconditioning injury promotes regeneration via a redox signalling dependent mechani
Externí odkaz:
https://doaj.org/article/6b41fe29aefd4cac8cb9f73f6e8e598a
Autor:
Susan E. Morgan, Alexandra Mosser, Soyeon Ahn, Tyler R. Harrison, Jue Wang, Qian Huang, Ashley Reynolds, Bingjing Mao, John L. Bixby
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Abstract Introduction: Incentivizing the development of interdisciplinary scientific teams to address significant societal challenges usually takes the form of pilot funding. However, while pilot funding is likely necessary, it is not sufficient for
Externí odkaz:
https://doaj.org/article/93f29eb709e64a3d97e0a83f8d352c4d
Autor:
Xueting Luo, Marcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, Saloni T. Mehta, Kinjal A. Thakor, Francisca Diaz, Jae K. Lee, Carlos T. Moraes, John L. Bixby, Vance P. Lemmon, Kevin K. Park
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 398-410 (2016)
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in mature C
Externí odkaz:
https://doaj.org/article/b2e6c11a964241089ed85d9b5858d3c9
Publikováno v:
BioTechniques, Vol 41, Iss 5, Pp 619-624 (2006)
Manipulating gene expression in primary neurons has been a goal for many scientists for over 20 years. Vertebrate central nervous system neurons are classically difficult to transfect. Most lipid reagents are inefficient and toxic to the cells, and t
Externí odkaz:
https://doaj.org/article/9362a3694c9f4775b62c632f5e14dd3a
Autor:
Nicholas O’Neill, John L. Bixby, Matt C. Danzi, Hassan Al-Ali, Vance Lemmon, Jeffrey A. Lowell
Publikováno v:
SLAS Discovery. 26:1337-1354
After injury to the central nervous system (CNS), both neuron-intrinsic limitations on regenerative responses and inhibitory factors in the injured CNS environment restrict regenerative axon growth. Instances of successful axon regrowth offer opportu
Autor:
Kar Men Mah, Wei Wu, Hassan Al-Ali, Yan Sun, Qi Han, Ying Ding, Melissa Muñoz, Xiao-Ming Xu, Vance P. Lemmon, John L. Bixby
Publikováno v:
Exp Neurol
Recovery from spinal cord injury (SCI) and other central nervous system (CNS) trauma is hampered by limits on axonal regeneration in the CNS. Regeneration is restricted by the lack of neuron-intrinsic regenerative capacity and by the repressive micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c80a7176470239239120268cff46b07
https://europepmc.org/articles/PMC9443329/
https://europepmc.org/articles/PMC9443329/
Autor:
Alexandra Mosser, Qian Huang, Susan E. Morgan, Soyeon Ahn, John L. Bixby, Bingjing Mao, Ashley Ryan, Tyler R. Harrison, Jue Wang
Publikováno v:
Informing Science: The International Journal of an Emerging Transdiscipline. 24:083-110
Aim/Purpose: There is ample evidence that team processes matter more than the characteristics of individual team members; unfortunately, very few empirical studies have examined communication process variables closely or tied them to team outcomes. B
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 5, Pp 851-855 (2021)
Neural Regeneration Research
Neural Regeneration Research
Adeno-associated virus (AAV) is an essential instrument in the neuroscientist's toolkit, which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression. In the field of neural regenerati
Autor:
Amit K Patel, Xin Duan, Mai T. Vu, Cynthia Berlinicke, Cassidy D. Lee, Karl J. Wahlin, Vance Lemmon, Santiago Vilar, Vinod Jaskula-Ranga, Hassan Al-Ali, Yang Hu, Tianlun Lu, Anna La Torre, Risa M. Broyer, Derek S. Welsbie, Katherine L. Mitchell, Donald J. Zack, Mikaela Louie, John L. Bixby, Robert N. Weinreb
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Axonal injury plays a major role in many neurodegenerative diseases. The dual leucine zipper kinase (DLK) signaling pathway is a key regulator of axonal injury-induced neuronal cell death; however, DLK also has an important role in promo
Autor:
Nick O'Neill, Kar Men Mah, Abdiel Badillo-Martinez, Victor Jann, John L. Bixby, Vance P. Lemmon
Publikováno v:
Experimental neurology. 354
Injuries to the cervical spinal cord represent around 60% of all spinal cord injuries (SCIs). A major priority for patients with cervical SCIs is the recovery of any hand or arm function. The similarities between human and rodent "reach-to-eat moveme