Zobrazeno 1 - 10
of 185
pro vyhledávání: '"John L Rubinstein"'
Autor:
Iga Kucharska, Špela Binter, Rajagopal Murugan, Stephen W Scally, Julia Ludwig, Katherine Prieto, Elaine Thai, Giulia Costa, Kan Li, Gillian Q Horn, Yevel Flores-Garcia, Alexandre Bosch, Taylor Sicard, John L Rubinstein, Fidel Zavala, S Moses Dennison, Georgia D Tomaras, Elena A Levashina, Paul Kellam, Hedda Wardemann, Jean-Philippe Julien
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010999 (2022)
Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains multiple central repeating NANP motifs; some of the most potent anti-infective antibodies against
Externí odkaz:
https://doaj.org/article/8c8d7d9367ac4e39a094144bab03ffbb
Autor:
Iga Kucharska, Lamia Hossain, Danton Ivanochko, Qiren Yang, John L Rubinstein, Régis Pomès, Jean-Philippe Julien
Publikováno v:
eLife, Vol 11 (2022)
Malaria is a global health burden, with Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) responsible for the majority of infections worldwide. Circumsporozoite protein (CSP) is the most abundant protein on the surface of Plasmodium sporozoites, a
Externí odkaz:
https://doaj.org/article/d77aa415a45c4b3ea7da0686d84f0e1a
Autor:
David J Yanofsky, Justin M Di Trani, Sylwia Król, Rana Abdelaziz, Stephanie A Bueler, Peter Imming, Peter Brzezinski, John L Rubinstein
Publikováno v:
eLife, Vol 10 (2021)
The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of co
Externí odkaz:
https://doaj.org/article/1d6aa07f32734bd39aa34dc44cea219b
Autor:
Iga Kucharska, Elaine Thai, Ananya Srivastava, John L Rubinstein, Régis Pomès, Jean-Philippe Julien
Publikováno v:
eLife, Vol 9 (2020)
Plasmodium sporozoites express circumsporozoite protein (CSP) on their surface, an essential protein that contains central repeating motifs. Antibodies targeting this region can neutralize infection, and the partial efficacy of RTS,S/AS01 – the lea
Externí odkaz:
https://doaj.org/article/e9f37c736a9f4e2ba78a3da2bcc96791
Publikováno v:
eLife, Vol 9 (2020)
The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development ag
Externí odkaz:
https://doaj.org/article/822beeb8932145e48d5d5f0bd6a2ecf3
Autor:
Zhijie Li, Aidan CA Tomlinson, Alan HM Wong, Dongxia Zhou, Marc Desforges, Pierre J Talbot, Samir Benlekbir, John L Rubinstein, James M Rini
Publikováno v:
eLife, Vol 8 (2019)
The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Report
Externí odkaz:
https://doaj.org/article/eed3c0e9a1a2460c8ad3b9c833f16c92
Publikováno v:
eLife, Vol 8 (2019)
ATP synthases produce ATP from ADP and inorganic phosphate with energy from a transmembrane proton motive force. Bacterial ATP synthases have been studied extensively because they are the simplest form of the enzyme and because of the relative ease o
Externí odkaz:
https://doaj.org/article/035c14f858f8430c81a9ae7f4de7605a
Autor:
Ana Paula Lobez, Fei Wu, Justin M. Di Trani, John L. Rubinstein, Mikael Oliveberg, Peter Brzezinski, Agnes Moe
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Recent studies have established that cellular electrostatic interactions are more influential than assumed previously. Here, we use cryo-EM and perform steady-state kinetic studies to investigate electrostatic interactions between cytochrome
Externí odkaz:
https://doaj.org/article/738fcf75ed4f40e2b9d85af5aa5ca206
Autor:
Jianhua Zhao, Ksenia Beyrakhova, Yao Liu, Claudia P Alvarez, Stephanie A Bueler, Li Xu, Caishuang Xu, Michal T Boniecki, Voula Kanelis, Zhao-Qing Luo, Miroslaw Cygler, John L Rubinstein
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006394 (2017)
Intracellular pathogenic bacteria evade the immune response by replicating within host cells. Legionella pneumophila, the causative agent of Legionnaires' Disease, makes use of numerous effector proteins to construct a niche supportive of its replica
Externí odkaz:
https://doaj.org/article/25983daec897429b9ce82b455086e88c
Autor:
Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay
Publikováno v:
eLife, Vol 6 (2017)
Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors s
Externí odkaz:
https://doaj.org/article/65b653e5554744cebb68c1ea76c5bd1d