Zobrazeno 1 - 10
of 220
pro vyhledávání: '"John L Rinn"'
Autor:
Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner
Publikováno v:
eLife, Vol 12 (2023)
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs rem
Externí odkaz:
https://doaj.org/article/3fce62d60c7b4d80ba98c9f07f7a3da0
Autor:
Christophe Bourges, Abigail F Groff, Oliver S Burren, Chiara Gerhardinger, Kaia Mattioli, Anna Hutchinson, Theodore Hu, Tanmay Anand, Madeline W Epping, Chris Wallace, Kenneth GC Smith, John L Rinn, James C Lee
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp 1-17 (2020)
Abstract Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could
Externí odkaz:
https://doaj.org/article/6f6d2d05ba2f4f178954073cc994019a
Autor:
Thomas A Carter, Manvendra Singh, Gabrijela Dumbović, Jason D Chobirko, John L Rinn, Cédric Feschotte
Publikováno v:
eLife, Vol 11 (2022)
The human endogenous retrovirus type-H (HERVH) family is expressed in the preimplantation embryo. A subset of these elements are specifically transcribed in pluripotent stem cells where they appear to exert regulatory activities promoting self-renewa
Externí odkaz:
https://doaj.org/article/8e4eb247256d4b97bde382a3e457328e
Autor:
Michael J Smallegan, Soraya Shehata, Savannah F Spradlin, Alison Swearingen, Graycen Wheeler, Arpan Das, Giulia Corbet, Benjamin Nebenfuehr, Daniel Ahrens, Devin Tauber, Shelby Lennon, Kevin Choi, Thao Huynh, Tom Wieser, Kristen Schneider, Michael Bradshaw, Joel Basken, Maria Lai, Timothy Read, Matt Hynes-Grace, Dan Timmons, Jon Demasi, John L Rinn
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0237055 (2021)
A key aspect in defining cell state is the complex choreography of DNA binding events in a given cell type, which in turn establishes a cell-specific gene-expression program. Here we wanted to take a deep analysis of DNA binding events and transcript
Externí odkaz:
https://doaj.org/article/3581be7dbf384cbd93c22a41d69897a4
Autor:
Jeffrey R Haswell, Kaia Mattioli, Chiara Gerhardinger, Philipp G Maass, Daniel J Foster, Paola Peinado, Xiaofeng Wang, Pedro P Medina, John L Rinn, Frank J Slack
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0252848 (2021)
Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of development. Here, we report the first described human embryonic stem cell (hESC) lines to repre
Externí odkaz:
https://doaj.org/article/0c003e912f964144b90286b77f64afc5
Autor:
Daniel Andergassen, Zachary D Smith, Jordan P Lewandowski, Chiara Gerhardinger, Alexander Meissner, John L Rinn
Publikováno v:
eLife, Vol 8 (2019)
Recent evidence has determined that the conserved X chromosome mega-structures controlled by the Firre and Dxz4 loci are not required for X chromosome inactivation (XCI) in cell lines. Here, we examined the in vivo contribution of these loci by gener
Externí odkaz:
https://doaj.org/article/1c2cab850748461eaf421c1d07f7c435
Publikováno v:
eLife, Vol 6 (2017)
The spatial organization of RNA within cells is a crucial factor influencing a wide range of biological functions throughout all kingdoms of life. However, a general understanding of RNA localization has been hindered by a lack of simple, high-throug
Externí odkaz:
https://doaj.org/article/87937a28b4ce4872b428be61b44e7ef8
Autor:
M Joaquina Delás, Leah R Sabin, Egor Dolzhenko, Simon RV Knott, Ester Munera Maravilla, Benjamin T Jackson, Sophia A Wild, Tatjana Kovacevic, Eva Maria Stork, Meng Zhou, Nicolas Erard, Emily Lee, David R Kelley, Mareike Roth, Inês AM Barbosa, Johannes Zuber, John L Rinn, Andrew D Smith, Gregory J Hannon
Publikováno v:
eLife, Vol 6 (2017)
A substantial fraction of the genome is transcribed in a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here, we systematically characterize transcriptional dynamics during hematopoiesis a
Externí odkaz:
https://doaj.org/article/e9c2590fa9734ed099eb3c9e83222b6f
Autor:
Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn
Publikováno v:
eLife, Vol 2 (2013)
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological cond
Externí odkaz:
https://doaj.org/article/5fdb35f4c02f45c69bc508db25a26cb3
Autor:
Michael B Clark, Paulo P Amaral, Felix J Schlesinger, Marcel E Dinger, Ryan J Taft, John L Rinn, Chris P Ponting, Peter F Stadler, Kevin V Morris, Antonin Morillon, Joel S Rozowsky, Mark B Gerstein, Claes Wahlestedt, Yoshihide Hayashizaki, Piero Carninci, Thomas R Gingeras, John S Mattick
Publikováno v:
PLoS Biology, Vol 9, Iss 7, p e1000625; discussion e1001102 (2011)
Externí odkaz:
https://doaj.org/article/0c29d3480ead4effa96e474f417fd1d0