Zobrazeno 1 - 10
of 622
pro vyhledávání: '"John L Markley"'
Autor:
Om Kumar Shrestha, Ruchika Sharma, Bartlomiej Tomiczek, Woonghee Lee, Marco Tonelli, Gabriel Cornilescu, Milena Stolarska, Lukasz Nierzwicki, Jacek Czub, John L Markley, Jaroslaw Marszalek, Szymon J Ciesielski, Elizabeth A Craig
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217098 (2019)
The J-domain protein Zuotin is a multi-domain eukaryotic Hsp70 co-chaperone. Though it is primarily ribosome-associated, positioned at the exit of the 60S subunit tunnel where it promotes folding of nascent polypeptide chains, Zuotin also has off-rib
Externí odkaz:
https://doaj.org/article/b09f12cb237047c2956e4aed7205ec36
Autor:
Brenda A Schilke, Szymon J Ciesielski, Thomas Ziegelhoffer, Erina Kamiya, Marco Tonelli, Woonghee Lee, Gabriel Cornilescu, Justin K Hines, John L Markley, Elizabeth A Craig
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007084 (2017)
By binding to a multitude of polypeptide substrates, Hsp70-based molecular chaperone systems perform a range of cellular functions. All J-protein co-chaperones play the essential role, via action of their J-domains, of stimulating the ATPase activity
Externí odkaz:
https://doaj.org/article/3b39ed135dee43bd8878ef4ccb38a39f
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177233 (2017)
Escherichia coli has been the most widely used host to produce large amounts of heterologous proteins. However, given an input plasmid DNA, E. coli may produce soluble protein, produce only inclusion bodies, or yield little or no protein at all. Many
Externí odkaz:
https://doaj.org/article/22fc0e4012ed4441b4539c63d7f781ca
Autor:
Kiran K Singarapu, Michele M Otte, Marco Tonelli, William M Westler, Jorge C Escalante-Semerena, John L Markley
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141297 (2015)
GTP:adenosylcobinamide-phosphate (AdoCbi-P) guanylyl transferase (CobY) is an enzyme that transfers the GMP moiety of GTP to AdoCbi yielding AdoCbi-GDP in the late steps of the assembly of Ado-cobamides in archaea. The failure of repeated attempts to
Externí odkaz:
https://doaj.org/article/3eca2b31f33c4a13a21c311e2bd1d3e1
Autor:
Woonghee Lee, Kelly E Watters, Andrew T Troupis, Nichole M Reinen, Fabian P Suchy, Kylie L Moyer, Ronnie O Frederick, Marco Tonelli, David J Aceti, Ann C Palmenberg, John L Markley
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97198 (2014)
Human rhinovirus strains differ greatly in their virulence, and this has been correlated with the differing substrate specificity of the respective 2A protease (2Apro). Rhinoviruses use their 2Apro to cleave a spectrum of cellular proteins important
Externí odkaz:
https://doaj.org/article/943f24431a2749f3bb299b7fa9fca771
Autor:
Arash Bahrami, Marco Tonelli, Sarata C Sahu, Kiran K Singarapu, Hamid R Eghbalnia, John L Markley
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33173 (2012)
ADAPT-NMR (Assignment-directed Data collection Algorithm utilizing a Probabilistic Toolkit in NMR) represents a groundbreaking prototype for automated protein structure determination by nuclear magnetic resonance (NMR) spectroscopy. With a [(13)C,(15
Externí odkaz:
https://doaj.org/article/f78bc75a01c141c8bb5f36ccfbf9c1a5
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000307 (2009)
The process of assigning a finite set of tags or labels to a collection of observations, subject to side conditions, is notable for its computational complexity. This labeling paradigm is of theoretical and practical relevance to a wide range of biol
Externí odkaz:
https://doaj.org/article/f76d1bae6cc7499ca26dc7e64162d333
Publikováno v:
Membranes. 12(9)
The heightened dipolar interactions in solids render solid-state NMR (ssNMR) spectra more difficult to interpret than solution NMR spectra. On the other hand, ssNMR does not suffer from severe molecular weight limitations like solution NMR. In recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9c6d133568c587f281b24a5aeb9f6f
https://pubmed.ncbi.nlm.nih.gov/36135853
https://pubmed.ncbi.nlm.nih.gov/36135853
Autor:
Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markley, Seth Frietze, Karen C. Glass
Publikováno v:
J Med Chem
Bromodomains are chromatin reader modules that recognize acetylated lysine. Different bromodomains exhibit a preference for specific patterns of lysine acetylation marks on core and variant histone proteins, however, the functional relationships that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8961c303018439c9f7b6ef608f6fb1de
https://doi.org/10.1021/acs.jmedchem.0c01178
https://doi.org/10.1021/acs.jmedchem.0c01178
Autor:
Nicolas W. Hengartner, Timothy H. Tran, Andrew G. Stephen, Daniel Scott, Oleg Chertov, Arvind Ramanathan, William K. Gillette, Debsindhu Bhowmik, Michael L. Gross, Mathias Lösche, Xiaoying Ye, Frank Heinrich, Que N. Van, Dhirendra K. Simanshu, Simon Messing, Marco Tonelli, Troy Taylor, Sandrasegaram Gnanakaran, John L. Markley, Patrick Alexander, Dominic Esposito, Christopher B. Stanley, Matt Drew, Ben Niu, Cesar A. Lopez, Dwight V. Nissley, William M. Westler, Peter Frank, Frank McCormick
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
The small GTPase KRAS is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor stimulation to intracellular signaling networks. In this process, KRAS recruits effectors, such as RAF kinase, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9286cfbd4800c04eaa75d171689e1440
https://doi.org/10.1073/pnas.2006504117
https://doi.org/10.1073/pnas.2006504117