Zobrazeno 1 - 10
of 94
pro vyhledávání: '"John L Fowlkes"'
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a
Autor:
Jeffry S. Nyman, Evangelia Kalaitzoglou, R. Clay Bunn, Sasidhar Uppuganti, Kathryn M. Thrailkill, John L. Fowlkes
Publikováno v:
Bone Reports, Vol 7, Iss C, Pp 1-8 (2017)
Those with type 1 diabetes (T1D) are more likely to suffer a fracture than age- and sex-matched individuals without diabetes, despite daily insulin therapy. In rodent studies examining the effect of bone- or glucose-targeting therapies on preventing
Externí odkaz:
https://doaj.org/article/919dfc139d4e4b9facd07bc85576a0cf
Publikováno v:
Current opinion in endocrinology, diabetes, and obesity. 29(4)
In this review, we describe the three primary mouse models of insulin-deficiency diabetes that have been used to study the effects of type 1 diabetes (T1D) on skeletal outcomes. These models include streptozotocin (chemically)-induced diabetes, autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b1380386c742246b9249a7c258e436
https://pubmed.ncbi.nlm.nih.gov/35749285
https://pubmed.ncbi.nlm.nih.gov/35749285
Autor:
John L. Fowlkes, Jeffry S. Nyman, R. Clay Bunn, Gael E. Cockrell, Elizabeth C. Wahl, Mallikarjuna R. Rettiganti, Charles K. Lumpkin Jr., Kathryn M. Thrailkill
Publikováno v:
Bone Reports, Vol 1, Iss C, Pp 16-19 (2015)
In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of fracture. Animal models of DBD demonstrate that acquired alterations in trabecular and cortical
Externí odkaz:
https://doaj.org/article/89a6b74e20f0427e9bcf2ebdc2dff0b3
Publikováno v:
Frontiers in Pediatrics. 10
In recent years, new therapies for the treatment of rare pediatric bone disorders have emerged, guided by an increasing understanding of the genetic and molecular etiology of these diseases. Herein, we review three such disorders, impacted by debilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1724c2cf34bf31289edde5b6ddb682
https://doi.org/10.3389/fped.2022.1012816
https://doi.org/10.3389/fped.2022.1012816
Autor:
Harshini Suresh Kumar, Edwina N. Barnett, Evangelia Kalaitzoglou, John L. Fowlkes, Ramkumar T. Annamalai
Diabetes is a chronic metabolic disorder that affects 422 million people worldwide and can lead to diabetic myopathy and bone diseases. The etiology of musculoskeletal complications in diabetes and the interplay between the muscular and osseous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efcdf7b64ef0115dcb3dba8080514b57
https://doi.org/10.1101/2022.10.05.510953
https://doi.org/10.1101/2022.10.05.510953
Autor:
Corey B. Hughes, George M. Mussman, Kathryn M. Thrailkill, Phil Ray, Virgilius Cornea, Robert C. Bunn, Iuliana Popescu, John L. Fowlkes
Publikováno v:
Cell and Tissue Research. 384:527-543
Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect exerted by the inhibition of glucose reabsorption in the kidney. Inhibition of SGLT2 is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c072ffe2c3a25971e234c3a1a212485d
https://doi.org/10.1007/s00441-020-03358-8
https://doi.org/10.1007/s00441-020-03358-8
Autor:
Sarah McDonald, Phil Ray, Robert C. Bunn, John L. Fowlkes, Kathryn M. Thrailkill, Iuliana Popescu
Publikováno v:
Acta histochemica. 124(7)
A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2 diabetes (T2D). New evidence suggests that in T2D, β-cells are not destroyed but experience a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ed562d71d6166d55246a313da60aa1
https://pubmed.ncbi.nlm.nih.gov/35969910
https://pubmed.ncbi.nlm.nih.gov/35969910
Autor:
Evangelia Kalaitzoglou, Phil Ray, R. Clay Bunn, Kathryn M. Thrailkill, Iuliana Popescu, John L. Fowlkes
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f798d38f20bbb033671ee76b7e5568a0
http://link.springer.com/article/10.1038/s41598-020-65717-3
http://link.springer.com/article/10.1038/s41598-020-65717-3
Publikováno v:
Journal of Clinical and Translational Science. 6:41-41
OBJECTIVES/GOALS: Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes. Though largely preventable, DKA is one of the most common acute complications of diabetes. In the US, rates of DKA hospitalization and associated costs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c590de0be311ff751df9bcc771962ef
https://doi.org/10.1017/cts.2022.135
https://doi.org/10.1017/cts.2022.135