Zobrazeno 1 - 10 of 35 pro vyhledávání: '"John Lövrot"'
1
Akademický článek
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
Autor: Michael Bartoschek, Nikolay Oskolkov, Matteo Bocci, John Lövrot, Christer Larsson, Mikael Sommarin, Chris D. Madsen, David Lindgren, Gyula Pekar, Göran Karlsson, Markus Ringnér, Jonas Bergh, Åsa Björklund, Kristian Pietras
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer-associated fibroblasts (CAFs) are an important component of the breast tumour microenvironment. Here, single-cell RNA sequencing of CAFs from a mouse model of breast cancer defines three transcriptomically distinct subpopulations with putative
Externí odkaz: https://doaj.org/article/1659aa31381d4c7a92e2ff7e1c638daf
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2
Akademický článek
PD-1 protein and gene expression as prognostic factors in early breast cancer
Autor: Christos Sotiriou, Antonis Valachis, Alexios Matikas, Ioannis Zerdes, John Lövrot, Emmanouil Sifakis, Francois Richard, Georgios Rassidakis, Theodoros Foukakis
Publikováno v: ESMO Open, Vol 5, Iss 6 (2020)
Background There is a paucity of data on the prognostic value of programmed cell death protein 1 (PD-1) protein and gene expression in early breast cancer (BC) and the present study’s aim was to comprehensively investigate it.Methods The study cons
Externí odkaz: https://doaj.org/article/2ebcd0486dac40868b6ee7df5066751a
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3
Akademický článek
Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling
Autor: Govindasamy-Muralidharan Karthik, Mattias Rantalainen, Gustav Stålhammar, John Lövrot, Ikram Ullah, Amjad Alkodsi, Ran Ma, Lena Wedlund, Johan Lindberg, Jan Frisell, Jonas Bergh, Johan Hartman
Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Transcriptomic profiling of breast tumors provides opportunity for subtyping and molecular-based patient stratification. In diagnostic applications the specimen profiled should be representative of the expression profile of the wh
Externí odkaz: https://doaj.org/article/c44ea55cc846474487dfc35c4ac3061b
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4
Akademický článek
Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer
Autor: Alexios Matikas, John Lövrot, Anna Ramberg, Margareta Eriksson, Therese Lindsten, Tobias Lekberg, Ingrid Hedenfalk, Niklas Loman, Jonas Bergh, Thomas Hatschek, Ann Erlandsson, Theodoros Foukakis
Publikováno v: OncoImmunology, Vol 7, Iss 9 (2018)
Gene expression (GE) signatures and Tumor Infiltrating Lymphocytes (TIL) enumeration are predictive for response to neoadjuvant chemotherapy in HR- and in HER2+ breast cancer, but data are conflicting in HR+/HER2- disease. This study aimed to explore
Externí odkaz: https://doaj.org/article/ae7ace0d4c5c4cc387f40768c42685a6
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6
Data from Prognostic Implications of PD-L1 Expression in Breast Cancer: Systematic Review and Meta-analysis of Immunohistochemistry and Pooled Analysis of Transcriptomic Data
Autor: Theodoros Foukakis, Antonios Valachis, Jonas Bergh, Christos Sotiriou, François Richard, John Lövrot, Ioannis Zerdes, Alexios Matikas
Purpose:Conflicting data have been reported on the prognostic value of PD-L1 protein and gene expression in breast cancer.Experimental Design: Medline, Embase, Cochrane Library, and Web of Science Core Collection were searched, and data were extracte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dc1ca067caa31a6b377db1add25cb1
https://doi.org/10.1158/1078-0432.c.6527996
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