Understanding the molecular determinants driving the immunological specificity of the protective pilus 2a backbone protein of group B streptococcus.

Autor: Annalisa Nuccitelli, C Daniela Rinaudo, Barbara Brogioni, Roberta Cozzi, Mario Ferrer-Navarro, Daniel Yero, John L Telford, Guido Grandi, Xavier Daura, Martin Zacharias, Domenico Maione

Publikováno v: PLoS Computational Biology, Vol 9, Iss 6, p e1003115 (2013)

The pilus 2a backbone protein (BP-2a) is one of the most structurally and functionally characterized components of a potential vaccine formulation against Group B Streptococcus. It is characterized by six main immunologically distinct allelic variant

Externí odkaz: https://doaj.org/article/c214f3573e9e49aabd3daa62b2b5b92d

Structural basis for group B streptococcus pilus 1 sortases C regulation and specificity.

Autor: Roberta Cozzi, Daniil Prigozhin, Roberto Rosini, Francesca Abate, Matthew J Bottomley, Guido Grandi, John L Telford, C Daniela Rinaudo, Domenico Maione, Tom Alber

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49048 (2012)

Gram-positive bacteria assemble pili through class C sortase enzymes specialized in polymerizing pilin subunits into covalently linked, high-molecular-weight, elongated structures. Here we report the crystal structures of two class C sortases (SrtC1

Externí odkaz: https://doaj.org/article/e5a5c9bd38f241e79d383985c730baf0

Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.

Autor: Francesca Necchi, Vincenzo Nardi-Dei, Massimiliano Biagini, Michael Assfalg, Annalisa Nuccitelli, Roberta Cozzi, Nathalie Norais, John L Telford, C Daniela Rinaudo, Guido Grandi, Domenico Maione

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25300 (2011)

Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS), is one of the most common causes of life-threatening bacterial infections in infants. In recent years cell surface pili have been identified in several Gram-positive bacteria,

Externí odkaz: https://doaj.org/article/77ec078ca7cd481fa9d1adf6aa6e0b19

Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination

Autor: Kaihu Yao, C. Daniela Rinaudo, John L. Telford, Lucilla Baldassarri, Domenico Maione, Knud Poulsen, Mogens Kilian, Uffe B. Skov Sørensen

Publikováno v: Yao, K, Poulsen, K, Maione, D, Rinaudo, C D, Baldassarri, L, Telford, J L, Sørensen, U B S, Kilian, M & Members of the DEVANI Study Group 2013, ' Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination ', Journal of Clinical Microbiology, vol. 51, no. 2, pp. 503-7 . https://doi.org/10.1128/JCM.02417-12
Journal of Clinical Microbiology; Vol 51

We evaluated three different PCR-based capsular gene typing methods applied to 312 human and bovine Streptococcus agalactiae (group B Streptococcus [GBS]) isolates and compared the results to serotyping results obtained by latex agglutination. Among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93633324435b66221fcda75496132836
https://doi.org/10.1128/jcm.02417-12

The Protective Value of Maternal Group B Streptococcus Antibodies: Quantitative and Functional Analysis of Naturally Acquired Responses to Capsular Polysaccharides and Pilus Proteins in European Maternal Sera

Autor: Giulia Anderloni, Roberto Rosini, Fabio Rigat, Filippo Carboni, Sceida Khacheh, C. Daniela Rinaudo, Guido Grandi, Roberta Creti, Lucilla Baldassarri, Monica Fabbrini, Immaculada Margarit, John L. Telford, Irene Passalaqua, Domenico Maione

BACKGROUND Group B Streptococcus (GBS) is a major cause of neonatal sepsis and meningitis. A vaccine targeting pregnant women could protect infants through placentally transferred antibodies. The association between GBS maternal antibody concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed9f35f9eabe2647a42516351301c7a
http://hdl.handle.net/11572/175776