Zobrazeno 1 - 10
of 299
pro vyhledávání: '"John L, Neumeyer"'
Publikováno v:
Chemistry, Vol 3, Iss 3, Pp 1047-1056 (2021)
The dopamine D2 agonist MCL-524 is selective for the D2 receptor in the high-affinity state (D2high), and, therefore, the PET analogue, [18F]MCL-524, may facilitate the elucidation of the role of D2high in disorders such as schizophrenia. However, th
Externí odkaz:
https://doaj.org/article/5a1916e91d404f2aa0245d4f9b0a550a
Autor:
Youbai Chen, Alan B. Packard, John L. Neumeyer, Anna W. Sromek, Vamsidhar Akurathi, James A. H. Inkster
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Fluorine-18 radiolabeling typically includes several conserved steps including elution of the [18F]fluoride from an anion exchange cartridge with a basic solution of K2CO3 or KHCO3 and Kryptofix 2.2.2. in mixture of acetonitrile and water followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077b79cbd9506167828faee6438141e5
http://link.springer.com/article/10.1038/s41598-020-61845-y
http://link.springer.com/article/10.1038/s41598-020-61845-y
Publikováno v:
Chemistry
Volume 3
Issue 3
Pages 75-1056
Chemistry, Vol 3, Iss 75, Pp 1047-1056 (2021)
Volume 3
Issue 3
Pages 75-1056
Chemistry, Vol 3, Iss 75, Pp 1047-1056 (2021)
The dopamine D2 agonist MCL-524 is selective for the D2 receptor in the high-affinity state (D2high), and, therefore, the PET analogue, [18F]MCL-524, may facilitate the elucidation of the role of D2high in disorders such as schizophrenia. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1d7121767457a98a1c383a1a7e497f
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:230-233
A series of novel aporphine derivatives were synthesized for initial screening at the 5-HT2 receptor subtypes. Among them, Compounds 11a and 11b were identified as potent 5-HT2C hit ligands with high selectivity over other 5-HT2 receptor subtypes. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b833cc72f602d444ab8ba4a6b456d2
https://doi.org/10.1016/j.bmcl.2018.11.050
https://doi.org/10.1016/j.bmcl.2018.11.050
Publikováno v:
ACS Chem Neurosci
The dopamine D(2) receptor exists in two different states, D(2)(high) and D(2low); the former is the functional form of the D(2) receptor and associates with intracellular G-proteins. The D(2) agonist [(3)H]MCL-536 has high affinity for the D(2) rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f813fd6204b12b4423e55ec16e37b51
https://pubmed.ncbi.nlm.nih.gov/33844498
https://pubmed.ncbi.nlm.nih.gov/33844498
Publikováno v:
ACS Chem Neurosci
Increases in the D2 receptor high affinity state are associated with certain neurological disorders. We synthesized and characterized the high-affinity D2high ligand [(3)H]MCL-536 in competition binding against the D2/3 agonist R-(−)-N-n-propylnora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac8ae3a2d925a203e60932a1dfd9de6
https://doi.org/10.1021/acschemneuro.8b00096
https://doi.org/10.1021/acschemneuro.8b00096
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5811 (2009)
(+/-) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D(1)-like dopamine receptor agonistic activity. The precise mecha
Externí odkaz:
https://doaj.org/article/7508d982aa0449b3b4b8a817edb57a18
Autor:
Peter Jenner, Anna W. Sromek, Andrew J. Lees, Louise Lincoln, Sarah Rose, Michael J. Jackson, John L. Neumeyer, Ria Fisher
Publikováno v:
Movement Disorders. 31:1381-1388
Background The D1/D2 dopamine agonist apomorphine has poor oral bioavailability, necessitating subcutaneous administration in the treatment of Parkinson's disease (PD). Acute subcutaneous injection is used as rescue therapy from “off” periods, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c604e38f427589e5c64738425d70de04
https://doi.org/10.1002/mds.26626
https://doi.org/10.1002/mds.26626
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(2)
A series of novel aporphine derivatives were synthesized for initial screening at the 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86c2b56a495db415b9249cb1264d3891
https://pubmed.ncbi.nlm.nih.gov/30545651
https://pubmed.ncbi.nlm.nih.gov/30545651
Convenient synthesis of18F-radiolabeled R-(−)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine
Autor:
David Alagille, Gilles Tamagnan, Shaohui Zhang, John L. Neumeyer, R. M. Baldwin, Thomas J. Morley, Vamsidhar Akurathi, Wei Li, Anna W. Sromek, Alan B. Packard
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:725-729
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2536422dcef868d9cf3930f360342093
https://doi.org/10.1002/jlcr.3246
https://doi.org/10.1002/jlcr.3246