Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John L, Kane"'
Autor:
Patrick Shum, Thomas Licher, John L. Kane, Carolin Gerbeth-Kreul, Gerhard Hessler, Antje Pommereau, Sven Ruf, Christian Engel, Linli Wei, Joerg Czech, Theresa A Kuntzweiler
Publikováno v:
SLAS Discovery. 26:783-797
Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e4fb083c4e35d492c537df0250e79a
https://doi.org/10.1177/24725552211011180
https://doi.org/10.1177/24725552211011180
Autor:
Carolin, Gerbeth-Kreul, Antje, Pommereau, Sven, Ruf, John L, Kane, Theresa, Kuntzweiler, Gerhard, Hessler, Christian K, Engel, Patrick, Shum, LinLi, Wei, Joerg, Czech, Thomas, Licher
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(6)
Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9160baf68ccf7faf0016023ba5f4dc1
https://pubmed.ncbi.nlm.nih.gov/33955247
https://pubmed.ncbi.nlm.nih.gov/33955247
Autor:
Matija Zelic, Jose Sancho, Yi Li, Nellwyn Hagan, Oleg Butovsky, John L. Kane, Lisa Woodworth, Andrew Scholte, Charlotte Madore, Michael Kothe, Barbara Gisevius, Dimitry Ofengeim, Jacqueline Saleh, Jonathan Proto, Deepak Grover, Maria Fitzgerald, Aiden Haghikia, Jinyu Liu, Amy Mahan
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 10, Pp 1-25 (2020)
Cell Death and Disease, Vol 11, Iss 10, Pp 1-25 (2020)
Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc9ca138cd4d331e3ff620100313d25
http://europepmc.org/articles/PMC7584629
http://europepmc.org/articles/PMC7584629
Autor:
John L. Kane, Junkai Liao, Kevin D. Noson, Gary Asmussen, Yibin Xiang, Maria Fitzgerald, Christine Klaus, Bradford H. Hirth, Michael Booker, Christopher Yee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4550-4554
Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369c9d41ca3e07b0818f4eabf2709c0f
https://doi.org/10.1016/j.bmcl.2010.06.019
https://doi.org/10.1016/j.bmcl.2010.06.019
Publikováno v:
Organic Letters. 3:1081-1084
[structure: see text]. A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of beta'-bromo-alpha-diazo ketones with rhodium carboxylates. The key transformation involves intramolecular addition of a rhodium carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ad442482f521bb1e3aa09ee5bf83fa
https://doi.org/10.1021/ol0156897
https://doi.org/10.1021/ol0156897
Autor:
Gary Asmussen, Yibin Xiang, John L. Kane, Bradford H. Hirth, Christopher Yee, Kevin D. Noson, Michael Booker, Junkai Liao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6119-6121
Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a347c182cf62373121f9b662ce5ea70
https://doi.org/10.1016/j.bmcl.2009.09.022
https://doi.org/10.1016/j.bmcl.2009.09.022
Autor:
C. Ho, R. Fang, T. Gladysheva, N. Moran, A. Vardanyan, A. Bourque, Gloria Matthews, D. Blasioli, R. Dagher, Dinesh S. Bangari, C.R. Flannery, John L. Kane, M. Philbrook, M. Santos, K. Donahue
Publikováno v:
Osteoarthritis and Cartilage. 23:A45-A46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5cb6ed18fbfe33c5809d595296f111
https://doi.org/10.1016/j.joca.2015.02.100
https://doi.org/10.1016/j.joca.2015.02.100
Publikováno v:
ChemInform. 32
A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of β‘-bromo-α-diazo ketones with rhodium carboxylates. The key transformation involves intramolecular addition of a rhodium carbenoid to an arene π-bond,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93b2871ad08f022358f186afee73e90
https://doi.org/10.1002/chin.200128093
https://doi.org/10.1002/chin.200128093
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13bcc584aa9bd1bac814bedc6d587e1f
https://doi.org/10.1002/chin.200520067
https://doi.org/10.1002/chin.200520067