Zobrazeno 1 - 10
of 62
pro vyhledávání: '"John L, Darling"'
Autor:
Rajendra P. Pangeni, Ivonne Olivaries, David Huen, Vannessa C. Buzatto, Timothy P. Dawson, Katherine M. Ashton, Charles Davis, Andrew R. Brodbelt, Michael D. Jenkinson, Ivan Bièche, Lu Yang, Farida Latif, John L. Darling, Tracy J. Warr, Mark R. Morris
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Brain metastases comprise 40% of all metastatic tumours and breast tumours are among the tumours that most commonly metastasise to the brain, the role that epigenetic gene dysregulation plays in this process is not well understood. We carrie
Externí odkaz:
https://doaj.org/article/08b2c9c30d794134830e32dbafb71118
Autor:
Daniel Blakeway, Lawrence Eagles, Farjana B. Rowther, John L. Darling, Katherine Karakoula, Tracy Warr, Mark R. Morris
HK2 has a prominent role in glycolysis, acting as the rate-limiting step in the pathway. HK2 is highly expressed in many cancers, with overexpression associated with drug resistant phenotypes. In parallel, its inhibition has improved the effectivenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d2e852e0678ef20bf8d58a3e34a23a
https://europepmc.org/articles/PMC5791708/
https://europepmc.org/articles/PMC5791708/
Autor:
Katherine Karakoula, John L. Darling, Dominic Thompson, Thomas Jacques, Kim Phipps, Tracy Warr, Nelofer Syed
Aberrant cellular metabolism is recognized as a major event in the growth and development of many cancers and the targetting of metabolic defects in tumour cells represents a new therapeutic opportunity. For example, cells that do not express suffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499af0a56969708ee4f4e586886038db
https://europepmc.org/articles/PMC5791677/
https://europepmc.org/articles/PMC5791677/
Autor:
Timothy Dawson, Farjana B. Rowther, Tracy Warr, D. G. T. Thomas, Weinbin Wei, John L. Darling, Anushree Singh, Mylene P. Madiesse-Timchou, Katherine M. Ashton
Publikováno v:
Molecular Carcinogenesis. 55:268-279
Cyclic nucleotides (cAMP & cGMP) are critical intracellular second messengers involved in the transduction of a diverse array of stimuli and their catabolism is mediated by phosphodiesterases (PDEs). We previously detected focal genomic amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d55a45ea96b7ca62470d7ddd1f940d26
https://doi.org/10.1002/mc.22276
https://doi.org/10.1002/mc.22276
Autor:
John L. Darling, Tracy Warr, Timothy Dawson, Mark R. Morris, Daniel Blakeway, Katherine Karakoula, Farjana B. Rowther, Kate Ashton
Publikováno v:
Neuro-Oncology. 20:vi165-vi166
HK2 has a prominent role in aerobic glycolysis and has been implicated in many cancer types including GBM, with overexpression associated with drug resistant phenotypes. Previously, we have demonstrated HK2 expression was upregulated between 6 to >10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996e0f7116d608b563b468b95fcc4c7e
https://doi.org/10.1093/neuonc/noy148.689
https://doi.org/10.1093/neuonc/noy148.689
Autor:
Peng Liu, James Z. Tang, Wen Guo Jiang, Vinodh Kannappan, Angel L. Armesilla, I S Kumar, Weiguang Wang, John L. Darling, Sarah Brown, Patricia Erebi Tawari
Publikováno v:
British Journal of Cancer
Background: Triple-negative breast cancer (TNBC) has significantly worse prognosis. Acquired chemoresistance remains the major cause of therapeutic failure of TNBC. In clinic, the relapsed TNBC is commonly pan-resistant to various drugs with complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9c204c33665b5cdc9bf6004235a14d
https://doi.org/10.1038/bjc.2013.534
https://doi.org/10.1038/bjc.2013.534
Autor:
Xiu-Wu Bian, Peng Liu, T Goktug, P. Channathodiyil, Sarah Brown, John L. Darling, P-O Guichet, Vinodh Kannappan, Weiguang Wang, Angel L. Armesilla, J-P Hugnot
Publikováno v:
British Journal of Cancer
Background: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5548b8ba79e888dfc407bc22b946ad2a
https://doi.org/10.1038/bjc.2012.442
https://doi.org/10.1038/bjc.2012.442
Autor:
John L. Darling, Mark R. Morris, Charles Davis, Weiguang Wang, Rajendra P. Pangeni, Michael D. Jenkinson, Tracy Warr, Ivonne Olivares, Andrew Brodbelt, David Huen, Katherine M. Ashton, Timothy Dawson
Publikováno v:
European Journal of Surgical Oncology. 43:2233-2234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4980b708eff4337aaec9d802c02f2988
https://doi.org/10.1016/j.ejso.2017.10.170
https://doi.org/10.1016/j.ejso.2017.10.170
Autor:
John L. Darling, Angel L. Armesilla, Jim Cassidy, Sumi Mathew, Xiaoxia Guo, Weiguang Wang, Bing Xu
Publikováno v:
Cancer Letters. 291:200-208
The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce95ce1b4b5c4ecdb718d0f4e2afd7f
https://doi.org/10.1016/j.canlet.2009.10.013
https://doi.org/10.1016/j.canlet.2009.10.013
Autor:
Elisabeth Goessl, James Brown, Angel L. Armesilla, Xiaoxia Guo, Shuchita Pandey, Bing Xu, Weiguang Wang, John L. Darling
Publikováno v:
Cancer Letters. 290:104-113
Most of the gemcitabine (dFdC) resistant cell lines manifested high NFkappaB activity. The NFkappaB activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of disulfiram (DS), an anti-alcoholism drug and NFkappaB inhibitor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddee6818d9cd5e59cddcddc55220e874
https://doi.org/10.1016/j.canlet.2009.09.002
https://doi.org/10.1016/j.canlet.2009.09.002