Zobrazeno 1 - 2
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pro vyhledávání: '"John Kunich"'
Autor:
John Kunich, Serah Choi, Kusum Pandey, Larry Boyle, Bridget Bagus, Yuqiao Shen, Gaston Habets, Frank McCormick, Conrado Soria, Dave Ginzinger, Annie Shen, Clodagh C. O’Shea, Cory R. Nicholas, Leisa Johnson
Publikováno v:
Cancer Cell. 6(6):611-623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-defective tumor cells. Here we show that loss of E1B-55K leads to the induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbb94f51c502a0a857c7dfaff612b2e
Autor:
Larry Boyle, Leisa Johnson, Frank McCormick, Annie Shen, John Kunich, Ali Fattaey, Terry Hermiston, Marilyn Lemmon, Marty Giedlin, Kusum Pandey
Publikováno v:
Cancer Cell. 1:325-337
We have engineered a human adenovirus, ONYX-411, that selectively replicates in human tumor cells, but not normal cells, depending upon the status of their retinoblastoma tumor suppressor protein (pRB) pathway. Early and late viral gene expression as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4262cc0f6caa4e11eea2ec6e59cbd2b9
https://doi.org/10.1016/s1535-6108(02)00060-0
https://doi.org/10.1016/s1535-6108(02)00060-0