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Akademický článek

The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement

Publikováno v: Frontiers in Allergy, Vol 2 (2021)

Motivation: The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in gene

Externí odkaz: https://doaj.org/article/c6d13eb198294ceebba143d7e3429f0c

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Functional classification of protein toxins as a basis for bioinformatic screening

Autor: Gregory S. Ladics, Lucilia Pereira Mouriès, Lieven Sterck, Peter Chang, Sabitha Papineni, Henry P. Mirsky, Jean Baptiste Rascle, John Kough, Joseph M. Jez, Catherine H. Schein, Surendra S. Negi, Werner Braun

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
SCIENTIFIC REPORTS
Scientific Reports

Proteins are fundamental to life and exhibit a wide diversity of activities, some of which are toxic. Therefore, assessing whether a specific protein is safe for consumption in foods and feeds is critical. Simple BLAST searches may reveal homology to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473519ee052870e1320bbd513505a648
http://link.springer.com/article/10.1038/s41598-017-13957-1

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Assessment of potential adjuvanticity of Cry proteins

Autor: Gregory S. Ladics, Scott McClain, John Kough, Rod A. Herman, Penny Hunst, Saurabh S. Joshi, Kevin C. Glenn, Nancy G. Doerrer, Ronald van Ree, Jean-Baptiste Rascle, Sabitha Papineni, Brian Barnett, Christal C. Bowman, Jason M. Ward, Corinne Herouet-Guicheney, Ai-Lin Tao, Lars K. Poulsen

Publikováno v: Regulatory toxicology and pharmacology, 79, 149-155. Academic Press Inc.

Genetically modified (GM) crops have achieved success in the marketplace and their benefits extend beyond the overall increase in harvest yields to include lowered use of insecticides and decreased carbon dioxide emissions. The most widely grown GM c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34ee82f8ff89e6310b0d5710d8f30f0
https://doi.org/10.1016/j.yrtph.2016.04.005

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Editor’s Choice: Evaluating the Potential for Adverse Interactions within Genetically Engineered Breeding Stacks

Autor: Natalie N. Weber, Claire Halpin, Henry-York Steiner, L. Curtis Hannah, Wayne A. Parrott, John Kough, Lynne Underhill, Joseph M. Jez

Publikováno v: Plant Physiology. 161:1587-1594

Plant breeding has a long history of developing varieties with desirable traits in response to the needs of both growers and consumers. Although the bases for most of these traits are not known genetically or biochemically, conventional breeding comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f4c32086393d2df5af703130878b329
https://doi.org/10.1104/pp.112.209817

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Editor’s Choice: Crop Genome Plasticity and Its Relevance to Food and Feed Safety of Genetically Engineered Breeding Stacks

Autor: Claire Halpin, Natalie N. Weber, L. Curtis Hannah, Joseph M. Jez, Wayne A. Parrott, John Kough

Publikováno v: Plant Physiology. 160:1842-1853

Genetically engineered (GE) stacks, combinations of two or more single transgenic events (i.e. single-locus insertions) that have been produced by crossing sexually compatible parents, are an important and growing sector of the crop seed market. Stac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65dc72e3a08c63f693effe6bf896fef2
https://doi.org/10.1104/pp.112.204271

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The Safety of Bacillus thuringiensis for Human Consumption

Autor: John Kough

Publikováno v: Journal of New Seeds. 5:1-10

Bacillus thuringiensis (Bt) provides one of the most prominent biologically based pesticides. Bt affords a high degree of safety to the environment, non-target organisms and humans in combination with its effectiveness in controlling numerous insect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e7d38e1b18caa9debe2d52bd82231b
https://doi.org/10.1300/j153v05n01_01

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Toxicological evaluation of proteins introduced into food crops

Autor: Bruce, Hammond, John, Kough, Corinne, Herouet-Guicheney, Joseph M, Jez, Flavio, Zambrone

Publikováno v: Critical Reviews in Toxicology

This manuscript focuses on the toxicological evaluation of proteins introduced into GM crops to impart desired traits. In many cases, introduced proteins can be shown to have a history of safe use. Where modifications have been made to proteins, expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63356b7c8ccf349180480c6739af96f
https://pubmed.ncbi.nlm.nih.gov/24164515

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The N-terminal 303 amino acids of the human cytomegalovirus envelope glycoprotein B (UL55) and the exon 4 region of the major immediate early protein 1 (UL123) induce a cytotoxic T-cell response

Autor: Eva Gonczol, Klara Berencsi, Robert F. Rando, Valéria Endrész, John Kough, Stanley A. Plotkin, Shin Takeda, Zsofia Gyulay

Publikováno v: Vaccine. 14:369-374

We reported earlier that an adenovirus (Ad) recombinant expressing the full-length human cytomegalovirus (HCMV) glycoprotein B (gB) gene induces gB-specific cytotoxic T lymphocyte (CTL) responses in CBA (H-2k) mice (Berencsi et al., J. Gen. Virol. 74

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca714d1c1c524795dd96f481427c6c9
https://doi.org/10.1016/0264-410x(95)00227-r

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