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Akademický článek

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain mo

Externí odkaz: https://doaj.org/article/58327b67c3514927a9a253f4bd3c8f1f

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Akademický článek

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

Autor: Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric Sturgill, Sarah Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Rodina, John Koren III, Michael W. Becker, Charles M. Rudin, Ari Melnick, Ross L. Levine, Gail J. Roboz, Stephen D. Nimer, Gabriela Chiosis, Monica L. Guzman

Publikováno v: Cell Reports, Vol 13, Iss 10, Pp 2159-2173 (2015)

Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from relapsed disease. Irrespective of mutation status, the development of aggressive leukemias is en

Externí odkaz: https://doaj.org/article/03d9a17749844c7d85caa19fad88d006

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Akademický článek

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies

Autor: Lindsey B. Shelton, John Koren, Laura J. Blair

Publikováno v: Frontiers in Neuroscience, Vol 11 (2017)

The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading aberrant proteins. Tau, a microtubule associated protein, aberrantly accumulates in Alzhei

Externí odkaz: https://doaj.org/article/8d0491ee745647938580bddead27f441

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Akademický článek

Human cyclophilin 40 unravels neurotoxic amyloids.

Autor: Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blair

Publikováno v: PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)

The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in

Externí odkaz: https://doaj.org/article/b8e1004e37a14f80868d70e4b48f50e7

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Akademický článek

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.

Autor: John Koren, Yoshinari Miyata, Janine Kiray, John C O'Leary, Lana Nguyen, Jianping Guo, Laura J Blair, Xiaokai Li, Umesh K Jinwal, Jin Q Cheng, Jason E Gestwicki, Chad A Dickey

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35566 (2012)

MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. However, complications prevented the use of this compound beyond clinical trials. Here we describe YM-1, a derivative of MKT-077. We found that YM-1 was more cytotoxic and

Externí odkaz: https://doaj.org/article/5a1f2f7e12414802a13741110362ebfe

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