Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John Kong-a San"'
Autor:
Petros Papadopoulos, Laura Gutiérrez, Reinier van der Linden, John Kong-A-San, Alex Maas, Dubravka Drabek, George P Patrinos, Sjaak Philipsen, Frank Grosveld
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51272 (2012)
The human β-globin locus contains the β-like globin genes (i.e. fetal γ-globin and adult β-globin), which heterotetramerize with α-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disorders in the
Externí odkaz:
https://doaj.org/article/f787f09f7b2d4671a318f9e93972cb09
Autor:
Bastian Stielow, Imme Krüger, Rolf Diezko, Florian Finkernagel, Nynke Gillemans, John Kong-a-San, Sjaak Philipsen, Guntram Suske
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001203 (2010)
SUMO modification of transcription factors is linked to repression of transcription. The physiological significance of SUMO attachment to a particular transcriptional regulator, however, is largely unknown. We have employed the ubiquitously expressed
Externí odkaz:
https://doaj.org/article/9e85d90ff03d42879c120e667850bfeb
Publikováno v:
Transgenic Research
Transgenic Research, 26(2), 237-246. Springer Netherlands
Transgenic Research, 26(2), 237-246. Springer Netherlands
In spite of the emergence of genome editing tools, ES cell mediated transgenesis remains the most controllable way of creating genetically modified animals. Although tetraploid (4N) complementation of 4N host embryos and ES cells, is the only method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7657ad2927738aed97b6bc7ed7d92ba9
http://europepmc.org/articles/PMC5350236
http://europepmc.org/articles/PMC5350236
Autor:
Eddy Rubin, Caroline L. Speck, Pik-Shan Li, John Kong-a-San, Matthew Burgess, Andrew Jarratt, Marella F. T. R. de Bruijn, Wade T. Nottingham, Shyam Prabhakar, Jan Fang Cheng, Jackie Sloane-Stanley
The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in the major vasculature of the mouse embryo. As a pivotal factor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d62f61d1b4e214e1ef280a6e1b6094
https://ora.ox.ac.uk/objects/uuid:d1babc62-db8d-4f7c-be6a-53c10ee203dd
https://ora.ox.ac.uk/objects/uuid:d1babc62-db8d-4f7c-be6a-53c10ee203dd
Autor:
George Panayotou, Rick Janssens, Rudi W. Hendriks, Sylvia Dekker, John Kong-a San, Alexandra van Remoortere, Frank Grosveld, Dubravka Drabek
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 103(41), 15130-15135. National Academy of Sciences
We have generated transgenic mice containing hybrid llama/human antibody loci that contain two llama variable regions and the human D, J, and Cμ and/or Cγ constant regions. Such loci rearrange productively and rescue B cell development efficiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5f92db45e71b14abbb5d003aca5358
https://hdl.handle.net/1765/14099
https://hdl.handle.net/1765/14099
Autor:
John Strouboulis, Mariken de Krom, John Kong-a-San, A. M. Ali Imam, Frank Grosveld, Nicholas P. Anagnou, Eleni Katsantoni
Publikováno v:
Experimental Hematology, 32, 224-233. Elsevier Inc.
Objective Persistent expression of the human fetal γ-globin genes in the adult stage is often associated with naturally occurring deletions in the human β-globin locus. The mapping of the 5′ breakpoints of these deletions within the A γ- to δ-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4ef27c4d703a7a7db0801256394905
https://pure.eur.nl/en/publications/56c42b32-0ebe-4663-8772-3807cabe394b
https://pure.eur.nl/en/publications/56c42b32-0ebe-4663-8772-3807cabe394b
Autor:
John Kong-a-San, Ton de Wit, Marella F. T. R. de Bruijn, Xiaoqian Ma, Marian Peeters, Corne Snoijs, Catherine Robin, Elaine Dzierzak
Publikováno v:
British Journal of Haematology. 116:401-408
Summary. The Sca-1 surface glycoprotein is used routinely as a marker for haematopoietic stem cell enrichment. Two allelic genes, Ly-6A and Ly-6E, encode this marker and appear to be differentially regulated in haematopoietic cells and haematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1e1472f57a0f22d64b9f5e689f5108b
https://doi.org/10.1046/j.1365-2141.2002.03250.x
https://doi.org/10.1046/j.1365-2141.2002.03250.x
Autor:
Frank Grosveld, Petros Papadopoulos, George P. Patrinos, Reinier van der Linden, Laura Gutierrez, Sjaak Philipsen, Dubravka Drabek, John Kong-a-San, Alex Maas
Publikováno v:
PLoS ONE
PLoS One (print), 7(12). Public Library of Science
PLoS ONE, Vol 7, Iss 12, p e51272 (2012)
PLoS One (print), 7(12). Public Library of Science
PLoS ONE, Vol 7, Iss 12, p e51272 (2012)
The human beta-globin locus contains the beta-like globin genes (i.e. fetal gamma-globin and adult beta-globin), which heterotetramerize with alpha-globin subunits to form fetal or adult hemoglobin. Thalassemia is one of the commonest inherited disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc777cb3c88b6a1ab16225eda210ac6
http://europepmc.org/articles/PMC3522686
http://europepmc.org/articles/PMC3522686
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 12, Iss 1, p 18 (2012)
BMC Developmental Biology, 12(1):18. BioMed Central Ltd.
BMC Developmental Biology, Vol 12, Iss 1, p 18 (2012)
BMC Developmental Biology, 12(1):18. BioMed Central Ltd.
Background To facilitate the in vivo study of esophageal (stem) cell biology in homeostasis and cancer, novel mouse models are necessary to elicit expression of candidate genes in a tissue-specific and inducible fashion. To this aim, we developed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f64404b5fc36346db90aaaa2aeabe79
https://doi.org/10.1186/1471-213x-12-18
https://doi.org/10.1186/1471-213x-12-18
Autor:
Pik-Shan Li, Jackie A. Sharpe, Caroline L. Speck, Jackie Sloane-Stanley, Debbie Barton, John Kong-a-San, Matthew Burgess, Marella F. T. R. de Bruijn, Wade T. Nottingham
Publikováno v:
BLOOD CELLS MOLECULES AND DISEASES. 38(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf112223bddb13e51083b0307a34fe9c
http://ora.ox.ac.uk/objects/uuid:e4f1dba4-f98e-4c51-86ba-c55103701d8e
http://ora.ox.ac.uk/objects/uuid:e4f1dba4-f98e-4c51-86ba-c55103701d8e