Zobrazeno 1 - 10
of 941
pro vyhledávání: '"John Knight"'
Autor:
Jennifer Pett, Christine Linhart, Nicholas Osborne, Stephen Morrell, Mohammed Fahim, John Knight, Shakila Premaranthne, A. W. M. Wazil, Neelakanthi Ratnatunga, Sulcochana Wijethunga, Shenal Thalgahagoda, Zoltan Endre, Richard Taylor, Nishantha Nanayakkara
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Chronic kidney disease (CKD) is a significant clinical challenge in Sri Lanka. The present study presents histopathological diagnoses from native renal biopsies in Kandy District, 2011–2020. Methods Reports of 5,014 renal biopsi
Externí odkaz:
https://doaj.org/article/a7ba87c5d9d44d4ebe706e1d6b64ebd3
Autor:
Joe Carroll, Catalina Lopez Manzano, Eve Tomlinson, Ayman Sadek, Chris Cooper, Hayley E Jones, Lorraine Rowsell, John Knight, Andrew Mumford, Rachel Palmer, William Hollingworth, Nicky J. Welton, Penny Whiting
Publikováno v:
Health Technology Assessment, Vol 28, Iss 57 (2024)
Background Stroke or transient ischaemic attack patients are at increased risk of secondary vascular events. Antiplatelet medications, most commonly clopidogrel, are prescribed to reduce this risk. Factors including CYP2C19 genetic variants can hinde
Externí odkaz:
https://doaj.org/article/9fe23a35a7de4c0994e943ca0b06e2b6
Autor:
Raquel Duchen, Luke Mondor, Jodi Gatley, Refik Saskin, Jeff Bakal, Ted McDonald, John Knight, Nathan Nickel, Charles Burchill, Erik Youngson, Sandra Magalhaes, Andrew Goosen, Sonya Bowen, Lisa Flaten, Natalie Troke, Christine Warren, Zoe Hsu, Xueyi Chen, Lihui Liu, Yan Wang, Chandy Somayaji, Linyun Shen, Simon Youssef, Sarah Magee, Daniel Dutton
Publikováno v:
International Journal of Population Data Science, Vol 9, Iss 5 (2024)
Objective and Approach Canada’s federated health data system along with access pathways geared toward academic research, pose challenges for knowledge Users (KUs) requiring timely, pan-Canadian evidence to inform decisions. To understand challenges
Externí odkaz:
https://doaj.org/article/6ed7b11f16e74da7aae6355a436f41fb
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101765- (2024)
Primary Hyperoxaluria Type 3 (PH3) results from 4-hydroxy-2-oxoglutarate (HOG) aldolase (HOGA) deficiency, which causes an increase in endogenous oxalate synthesis leading to calcium oxalate kidney stone disease. The mechanisms underlying HOG metabol
Externí odkaz:
https://doaj.org/article/3156737256c6472b8c6f5c9915552811
Autor:
Bahareh Ahmadzadeh, Christopher Patey, Oliver Hurley, John Knight, Paul Norman, Alison Farrell, Stephen Czarnuch, Shabnam Asghari
Publikováno v:
JMIR Research Protocols, Vol 13, p e52612 (2024)
BackgroundLong wait times in the emergency department (ED) are a major issue for health care systems all over the world. The application of artificial intelligence (AI) is a novel strategy to reduce ED wait times when compared to the interventions in
Externí odkaz:
https://doaj.org/article/4fa8235bcd8a48e0ae2f4a9375a4aed3
Autor:
Kris Aubrey-Bassler, Zhiwei Gao, Jennifer Rayner, John Knight, Maude Laberge, William Hogg, Joan Tranmer, Julia Lukewich, Mylaine Breton, Cheryl Etchegary, Ashley Ryan
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Over the last 20 years, the Canadian province of Ontario implemented several new models of primary care focusing on changes to physician remuneration, clinics led by nurse practitioners and the introduction of interprofessional primary c
Externí odkaz:
https://doaj.org/article/d25607b0f63d46b682caa21112f4e414
Autor:
Benjamin Talbot, Sara Farnbach, Allison Tong, Steve Chadban, Shaundeep Sen, Vincent Garvey, Martin Gallagher, John Knight
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 9 (2022)
Background: Numerous factors influence patient recruitment to, and retention on, peritoneal dialysis (PD), but a major challenge is a perceived “inaccessibility” to treating clinicians. It has been suggested that remote patient monitoring (RPM) c
Externí odkaz:
https://doaj.org/article/fa265e92ec5f45f5b129c6c410c57522
Publikováno v:
Kidney International Reports, Vol 5, Iss 7, Pp 1040-1051 (2020)
Introduction: Crystalluria is thought to be associated with kidney stone formation and can occur when urine becomes supersaturated with calcium, oxalate, and phosphate. The principal method used to identify urinary crystals is microscopy, with or wit
Externí odkaz:
https://doaj.org/article/3a30b95904914809a11967cf079be7ad
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101138- (2021)
Objective: Hydroxyacylglutathione hydrolase (aka as GLO-2) is a component of the glyoxalase pathway involved in the detoxification of the reactive oxoaldehydes, glyoxal and methylglyoxal. These reactive metabolites have been linked to a variety of pa
Externí odkaz:
https://doaj.org/article/cbca25f732c047218b18091d90072a31
Autor:
David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts,
Externí odkaz:
https://doaj.org/article/5887f05591104f9e9068f2413b7885fd