Zobrazeno 1 - 10
of 64
pro vyhledávání: '"John Klingensmith"'
Autor:
Murim Choi, John Klingensmith
Publikováno v:
PLoS Genetics, Vol 5, Iss 2, p e1000395 (2009)
Point mutations in TBX1 can recapitulate many of the structural defects of 22q11 deletion syndromes (22q11DS), usually associated with a chromosomal deletion at 22q1.2. 22q11DS often includes specific cardiac and pharyngeal organ anomalies, but the p
Externí odkaz:
https://doaj.org/article/90ec27c871df483ba6217a0e9491c6f8
Publikováno v:
Developmental Dynamics. 244:564-576
Background: Morphogenesis of vertebrate craniofacial skeletal elements is dependent on a key cell population, the cranial neural crest cells (NCC). Cranial NCC are formed dorsally in the cranial neural tube and migrate ventrally to form craniofacial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e008602a095582544ca63ef111e5ad9
https://doi.org/10.1002/dvdy.24256
https://doi.org/10.1002/dvdy.24256
Publikováno v:
Developmental Dynamics. 244:277-288
The alimentary and respiratory organ systems arise from a common endodermal origin, the anterior foregut tube. Formation of the esophagus from the dorsal region and the trachea from the ventral region of the foregut primordium occurs by means of a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b707fc6799ce12a63d4e2969c34bae
https://doi.org/10.1002/dvdy.24219
https://doi.org/10.1002/dvdy.24219
Publikováno v:
Developmental Biology. 391(1):111-124
Esophageal atresia with tracheoesophageal fistula (EA/TEF) is a serious human birth defect, in which the esophagus ends before reaching the stomach, and is aberrantly connected with the trachea. Several mouse models of EA/TEF have recently demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7055e2d90c51c6057fe8379c001065
Autor:
John Klingensmith, Sarah R. Fausett
Publikováno v:
Wiley Interdisciplinary Reviews: Developmental Biology. 1:184-202
The mammalian trachea and esophagus share a common embryonic origin. They arise by compartmentalization of a single foregut tube, composed of foregut endoderm (FGE) and surrounding mesenchyme, around midgestation. Aberrant compartmentalization is tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ee771e743a27bf5d35df4cc6a7b288
https://doi.org/10.1002/wdev.12
https://doi.org/10.1002/wdev.12
Autor:
Li Zhang, Sarah R. Fausett, John Klingensmith, Peng Jin, Xinyu Zhao, Zhao-Qian Teng, Weixiang Guo, Chang-Mei Liu, Devin M. Christopher, Olivia L. George
Publikováno v:
Neuron. 70:924-938
SummaryIn adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e944d2a9eb977181ac7635d6ef83a8a9
https://doi.org/10.1016/j.neuron.2011.03.027
https://doi.org/10.1016/j.neuron.2011.03.027
Autor:
Andrew M. Ravanelli, John Klingensmith
Publikováno v:
Developmental Biology. 350(1):101-111
The cordon-bleu (Cobl) gene is widely conserved in vertebrates, with developmentally regulated axial and epithelial expression in mouse and chick embryos. In vitro, Cobl can bind monomeric actin and nucleate formation of unbranched actin filaments, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4127eb9a5f6dab886f107d43e8ec3
Publikováno v:
Journal of Molecular and Cellular Cardiology. 48:1255-1265
Bone morphogenetic protein (BMP) signaling regulates embryonic development of many organ systems and defective BMP signaling has been implicated in adult disorders of many of these systems. However, its relevance in cardiac disease has not been repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540d153ce3b9742478b43bed65170d43
https://doi.org/10.1016/j.yjmcc.2010.01.010
https://doi.org/10.1016/j.yjmcc.2010.01.010
Publikováno v:
American Journal of Medical Genetics Part C: Seminars in Medical Genetics. :43-51
Holoprosencephaly (HPE) is the most common malformation of the forebrain, resulting from a failure to completely septate the left and right hemispheres at the rostral end of the neural tube. Because of the tissue interactions that drive head developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b77e058567d18d5930958e080646e9
https://doi.org/10.1002/ajmg.c.30256
https://doi.org/10.1002/ajmg.c.30256
Publikováno v:
Development. 135:2425-2434
In mouse, left-right (L-R) patterning depends on asymmetric expression of Nodal around the node, leading to Nodal expression specifically in the left lateral plate mesoderm (LPM). Bone morphogenetic protein (BMP) signaling is also involved, but the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e8a4dedfd0a47cbdd36e2ad7a33f3
https://doi.org/10.1242/dev.018986
https://doi.org/10.1242/dev.018986