Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John K. Whisnant"'
Autor:
Mary E. Gordinier, Alpa Nick, Anca Chelariu-Raicu, Carola Leuschner, John K. Whisnant, Linda M Bavisotto, Renata R. Urban, Robert L. Coleman, Graziela Zibetti Dal Molin
Publikováno v:
Gynecologic Oncology. 160:418-426
Objective This randomized open-label phase II study evaluated the safety and clinical activity of EP-100 plus weekly paclitaxel in patients with recurrent ovarian cancer expressing positive LHRH receptor. Methods In a limited “run-in” dose escala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb50bb89d5a20fa13d9a86bfc753888
https://doi.org/10.1016/j.ygyno.2020.11.013
https://doi.org/10.1016/j.ygyno.2020.11.013
Autor:
Kerry M. Barnhart, John Sarantopoulos, Mitesh J. Borad, Hector Alila, Carola Leuschner, Glen J. Weiss, Ramesh K. Ramanathan, John K. Whisnant, Kelly K. Curtis, Donald W. Northfelt
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose To conduct a phase I study determining the safety, pharmacokinetics and preliminary efficacy of EP-100, a novel anticancer drug consisting of natural luteinizing-hormone-releasing hormone (LHRH) ligand linked to a cationic membrane-disrupting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3656337bd0811375d315bc06c8c939cb
https://pubmed.ncbi.nlm.nih.gov/24610297
https://pubmed.ncbi.nlm.nih.gov/24610297
Autor:
Kathryn A. Mason, Hisanori Ariga, Robert Neal, David Valdecanas, Nancy Hunter, Arthur M. Krieg, John K. Whisnant, Luka Milas
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 11(1)
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs detected by Toll-like receptor 9 of dendritic cells and B cells have potent immunomodulatory effects. CpG oligodeoxynucleotides induce cytokines, activate natural killer cells, and el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6648a3159110902c800df4c9fe584c
https://pubmed.ncbi.nlm.nih.gov/15671522
https://pubmed.ncbi.nlm.nih.gov/15671522
Autor:
Donald W. Northfelt, Glen J. Weiss, John Sarantopoulos, Ramesh K. Ramanathan, Carola Leuschner, Kelly K. Curtis, John K. Whisnant, Manpreet Chadha, Kerry M. Barnhart, Hector Alila, Monica M. Mita
Publikováno v:
Journal of Clinical Oncology. 30:3060-3060
3060 Background: EP-100 is a synthetic 28 amino acid LHRH peptide conjugated to an 18 aa cytolytic peptide. Selective targeting in LHRH-R expressing cells occurs via direct binding to the extracellular membrane receptor followed by disruption of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2049dc5cbe8389add9aec0d4fcf45bf
https://doi.org/10.1200/jco.2012.30.15_suppl.3060
https://doi.org/10.1200/jco.2012.30.15_suppl.3060
Autor:
Judy N. Turner, Richard L. Tuttle, J. Scott Luther, Daniel D. Von Hoff, Patrick W. Cobb, William Wargin, John G. Kuhn, Dennis A. Tweedy, J. B. Craig, G. S. Harman, Jim M. Koeller, Geoffrey R. Weiss, John K. Whisnant, V. Sol Lucas, K. Havlin
Publikováno v:
Selective cancer therapeutics. 7(2)
Crisnatol is an arylmethylaminopropanediol derivative that has shown promise as an antitumor agent in preclinical testing. In a phase I trial using a monthly six-hour infusion schedule the recommended dose for future phase II trials was found to be 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a6408cf67a86f50cf6fca9e1706f1a
https://pubmed.ncbi.nlm.nih.gov/1754731
https://pubmed.ncbi.nlm.nih.gov/1754731
Autor:
Marc Buyse, Kristoffer Hellstrand, John K. Whisnant, Dileep Bhagwat, Mats Brune, Stephane E Allard, Pierre Squifflet, Jacob M. Rowe
Publikováno v:
Blood. 112:1948-1948
Background: Data from a randomized multinational trial of 320 adults with AML demonstrated that maintenance therapy with 3-week cycles of histamine dihydrochloride plus low-dose interleukin-2 (HDC/IL-2) for up to 18 months significantly improved leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70f514e39d8e62d3bceb3d586fe27ef
https://doi.org/10.1182/blood.v112.11.1948.1948
https://doi.org/10.1182/blood.v112.11.1948.1948
Autor:
Jeff Szer, Mats Brune, Jacob M. Rowe, Elisabeth Wallhult, Kristoffer Hellstrand, John K. Whisnant, Bo Nilsson, Dileep Bhagwat
Publikováno v:
Blood. 110:4381-4381
PURPOSE: To assess the impact on Quality of Life (QoL) of postconsolidation immunotherapy with histamine dihydrochloride (HDC) in combination with interleukin-2 (IL-2) in acute myelogenous leukemia (AML). PATIENTS & METHODS: A multi-national randomiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e65c2021e116f9e32d7120bff67f2c4
https://doi.org/10.1182/blood.v110.11.4381.4381
https://doi.org/10.1182/blood.v110.11.4381.4381
Publikováno v:
The American Journal of Medicine. 65:847-854
Lymphocytes from a patient with severe combined immunodeficiency (SCID) of the X-linked adenosine deaminase-positive type were studied in detail. Eighty per cent of peripheral blood cells were positive for surface immunoglobulins, the predominant flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8fab40699d58176f2f5768a113b0713
https://doi.org/10.1016/0002-9343(78)90805-7
https://doi.org/10.1016/0002-9343(78)90805-7
Autor:
Robert L. Baehner, John K. Whisnant, Jorge A. Ortega, Beatrice C. Lampkin, William Krivit, Phillip K. Weck, Harland N. Sather, R. Beverly Raney, Irwin O. Bernstein, G. Denman Hammond, Robert J. Wells
Publikováno v:
Journal of Interferon Research. 8:309-318
Twelve children ages 3-15 years with relapsed acute lymphocyte leukemia (ALL) were treated over 25 days by intravenous or intramuscular administration of interferon-αnl (IFN-αnl). Single doses rang...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c550a654e8b9c8537d1347fa0f28f3
https://doi.org/10.1089/jir.1988.8.309
https://doi.org/10.1089/jir.1988.8.309
Autor:
Rebecca H. Buckley, Richard B. Gilbertsen, John K. Whisnant, Marvin S. Platt, Andrew T. Huang, Richard I. Schiff
Publikováno v:
New England Journal of Medicine. 294:1076-1081
As an alternative to bone-marrow transplantation, two infants with severe combined immunodeficiency who had no histocompatible donors were given intraperitoneal infusions of fresh liver cells from fetuses of eight and nine to 10 weeks. Transient graf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e5574c0d319c57ec331b857360c54f
https://doi.org/10.1056/nejm197605132942002
https://doi.org/10.1056/nejm197605132942002