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pro vyhledávání: '"John K. Towns"'
Autor:
John K. Towns
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Biopharmaceuticals are most often administered to patients subcutaneously by way of a device delivery system, with these two components – biopharmaceutical and device – constituting the combination product. Combination products that employ differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa72850002ff4a5ce54aa8dee3c93e9
https://doi.org/10.1007/978-3-030-31415-6_32
https://doi.org/10.1007/978-3-030-31415-6_32
Autor:
John K. Towns
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 68:347-361
Interest in human factors usability testing has seen a sharp increase from manufacturers bringing new injectable pharmaceutical combination products to market and from regulators reviewing and approving submissions. This paper highlights the special
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f60ac5b5885d7cb4953225b992ace4
https://doi.org/10.5731/pdajpst.2014.00983
https://doi.org/10.5731/pdajpst.2014.00983
Autor:
Jody L. Roth, John K. Towns, Mark H. Mayer, John Michael Beals, Bruce H. Mitlak, Gregory C. Davis, Melissa Veenhuizen, Bruce I. Meiklejohn, Craig Johnson
Publikováno v:
Current Medical Research and Opinion. 25:1655-1661
Policy makers around the world are currently considering the creation of a regulatory pathway for follow-on biologics (FOB), which will have to account for the substantial technical challenges associated with FOB development. These challenges will li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e16f6caf4122b3986745fc909df1c9
https://doi.org/10.1185/03007990903017313
https://doi.org/10.1185/03007990903017313
Autor:
Fred E. Regnier, John K. Towns
Publikováno v:
Analytical Chemistry. 64:2473-2478
Adsorption of analytes to the walls of fused silica capillaries is common. This paper examines the quantitative impact of cationic polymer adsorption on electroosmotically driven transport, peak symmetry, and efficiency in capillary zone electrophore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50042b0b25bd7de59f1f20882f2325ed
https://doi.org/10.1021/ac00045a003
https://doi.org/10.1021/ac00045a003
Publikováno v:
Journal of Chromatography A. 599:227-237
This paper reports a diol-epoxy coating process to deactivate the inner surface of fused-silica capillaries for use in capillary zone electrophoresis. The most effective coating consists of an epoxy polymer covalently bonded to the silica surface thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bffa7a85eb72310a9f4fa73b7cd510f
https://doi.org/10.1016/0021-9673(92)85476-a
https://doi.org/10.1016/0021-9673(92)85476-a
Autor:
John K. Towns, Fred E. Regnier
Publikováno v:
Journal of Chromatography A. 516:69-78
A hydrophilic, positively charged, durable coating has been developed for capillary electrophoresis of macromolecules. Polyethyleneimine is adsorbed to the inner wall of fused silica capillaries and the adsorbed coating cross-linked into a stable lay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13bac3192060620652869a171529bf5
https://doi.org/10.1016/s0021-9673(01)90205-5
https://doi.org/10.1016/s0021-9673(01)90205-5
Autor:
Fred E. Regnier, John K. Towns
Publisher Summary Capillary electrophoresis (CE) is a rapid, high-resolution analytical technique for the separation of a wide variety of charged and uncharged species. Separations in electrophoresis are based on the differential migration rates of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a418512922d470b6980e53da6a39f6b
https://doi.org/10.1016/s1464-3456(96)80019-6
https://doi.org/10.1016/s1464-3456(96)80019-6
Autor:
Eugene C. Rickard, John K. Towns
Publisher Summary The general concept of peptide mapping (or peptide fingerprinting) is relatively simple. When proteins are subjected to enzymatic digestion or cleavage, by chemical reagents, they will be broken down into discrete fragments. These p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10abb04c7800150d7c65346781f535cd
https://doi.org/10.1016/s0076-6879(96)71013-3
https://doi.org/10.1016/s0076-6879(96)71013-3
Autor:
John K. Towns
Publikováno v:
Journal of chromatography. A. 705(1)
Residual moisture content has a significant impact on the solid-state stability of biopharmaceutical products. Protein degradation due to residual moisture is minimal at or below the monolayer level of hydration owing to low availability of water and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54545e42bc914b19c6ba6116539dbd57
https://pubmed.ncbi.nlm.nih.gov/7620565
https://pubmed.ncbi.nlm.nih.gov/7620565
Autor:
John K. Towns, Fred E. Regnier
Publikováno v:
Analytical chemistry. 63(11)
Capillary zone electrophoretic separations of proteins have been achieved by using nonionic surfactant coated capillaries. Capillaries were prepared by derivatization of the silica surface with octadecylsilane followed by the deposition of a layer of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7006f98e57fc034b5f57a19530c0f79b
https://pubmed.ncbi.nlm.nih.gov/1883070
https://pubmed.ncbi.nlm.nih.gov/1883070