Zobrazeno 1 - 10
of 42
pro vyhledávání: '"John K. Clark"'
Autor:
J. F. Phillips Bernal, Joseph Mascaro, Alvaro Duque, Guayana Paez-Acosta, Aravindh Balaji, David E. Knapp, Gregory P. Asner, E. Cabrera Montenegro, L. Maatoug, John K. Clark, K. D. Chadwick, P. von Hildebrand, M. C. García Dávila, D. A. Navarrete Encinales, James Jacobson, A. P. Yepes Quintero, Ty Kennedy-Bowdoin, G. A. Galindo García, M. F. Ordóñez
Publikováno v:
Biogeosciences, Vol 9, Iss 7, Pp 2683-2696 (2012)
High-resolution mapping of tropical forest carbon stocks can assist forest management and improve implementation of large-scale carbon retention and enhancement programs. Previous high-resolution approaches have relied on field plot and/or light dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0997e8f0503b356d58d1e5d8a07837dd
https://doi.org/10.5194/bg-9-2683-2012
https://doi.org/10.5194/bg-9-2683-2012
Autor:
Maurice Maidment, Angus John Morrison, Keneth Davies, Fiona Jeremiah, Grant Wishart, Alan Prosser, Robert A. Campbell, James Baker, Stuart Francis, Julia M. Adam, Ruth Fields, Susan Boyce, John K. Clark, Maureen Deehan, Jean E. Cottney, Takao Kiyoi, Iain Martin, Paul Ratcliffe, Kathryn Everett, Jurgen Schulz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2932-2937
Novel, low brain penetrant, orally bioavailable CB1 receptor agonists were designed starting from a mature lead series of potent brain penetrant CB1 receptor agonists. Increasing the calculated polar surface area was found to be a good strategy for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d42884ec55ac32b481759aa8c65fa3f
https://doi.org/10.1016/j.bmcl.2012.02.048
https://doi.org/10.1016/j.bmcl.2012.02.048
Autor:
Ty Kennedy-Bowdoin, Gregory P. Asner, David E. Knapp, James Jacobson, Amanda Uowolo, Joseph Mascaro, John K. Clark, R. Flint Hughes
Publikováno v:
Frontiers in Ecology and the Environment. 9:434-439
Current markets and international agreements for reducing emissions from deforestation and forest degradation (REDD) rely on carbon (C) monitoring techniques. Combining field measurements, airborne light detection and ranging (LiDAR)-based observatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d46f36597340f6b080a8704a711001
https://doi.org/10.1890/100179
https://doi.org/10.1890/100179
Autor:
Yasuko Kiyoi, Phillip M. Cowley, Ian Carlyle, James R. Baker, Thomas R. Clarkson, Grant Wishart, Dawn Osbourn, Iain J. Martin, Kirsteen Buchanan, Darren Edwards, Nick Ward, Maureen Deehan, John K. Clark, Glenn Walker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2034-2039
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d24af231886a7db08d0f88ddcb8863c
https://doi.org/10.1016/j.bmcl.2011.02.019
https://doi.org/10.1016/j.bmcl.2011.02.019
Autor:
Robert A. Campbell, Angus John Morrison, Julia M. Adam, Daniel Ecker, Stuart Francis, James Baker, Anna-Marie Easson, Fiona Jeremiah, Ola Epemolu, Takao Kiyoi, Roberta Bursi, Duncan McArthur, Jurgen Schulz, Darren Edwards, Paul Passier, Maureen Deehan, Paul Westwood, Joanna Udo de Haes, Peter G. Schnabel, Jean E. Cottney, John K. Clark, Glenn Walker, Paul Harradine, Heinz Steinbrede, Paul Ratcliffe, Grant Wishart, Ruth Fields, Jack Pick, Louise Evans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2541-2546
We report an expansion of the structure-activity relationship (SAR) of a novel series of indole-3-heterocyclic CB1 receptor agonists. Starting from the potent but poorly soluble lead, 1, a rational approach was taken in order to balance solubility, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac4fce3568bffcc8bec0c8ef27a0ea4
https://doi.org/10.1016/j.bmcl.2011.02.023
https://doi.org/10.1016/j.bmcl.2011.02.023
Autor:
Julia M. Adam, Kazuya Yoshiizumi, Paul Ratcliffe, Neil S. Keddie, Takao Kiyoi, Grant Wishart, Jurgen Schulz, Duncan McArthur, Angus John Morrison, John K. Clark, Karsten Meyer, James Baker, Jean E. Cottney, Maureen Deehan, Robert A. Campbell, Ruth Fields, Anna-Marie Easson, Stuart Francis, Fiona Jeremiah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:506-509
Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a bioisostere approach replacing a piperazine amide was undertaken. This was found to be a good stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff623a5aaaefc52bb58196f1c7a44a87
https://doi.org/10.1016/j.bmcl.2010.10.093
https://doi.org/10.1016/j.bmcl.2010.10.093
Autor:
Gregory P. Asner, George V. N. Powell, Joseph Mascaro, Aravindh Balaji, Ty Kennedy-Bowdoin, Eloy Victoria, Laura Secada, James Jacobson, John K. Clark, Guayana Paez-Acosta, R. Flint Hughes, Michael Valqui, David E. Knapp
Publikováno v:
Proceedings of the National Academy of Sciences. 107:16738-16742
Efforts to mitigate climate change through the Reduced Emissions from Deforestation and Degradation (REDD) depend on mapping and monitoring of tropical forest carbon stocks and emissions over large geographic areas. With a new integrated use of satel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671ae76c66726ed77318f7f8c6670637
https://doi.org/10.1073/pnas.1004875107
https://doi.org/10.1073/pnas.1004875107
Publikováno v:
Tetrahedron. 64:3119-3126
The asymmetric synthesis of the potent selective NOP agonist 2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-methyl-pentyl]-piperidin-4-yl}-2-oxo-2,3-dihydro-benzimidazol-1-yl)-N-methyl-acetamide and analogues was developed. The key step, chiral reduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97fd4598deb728b585cf59786d016ca8
https://doi.org/10.1016/j.tet.2008.01.125
https://doi.org/10.1016/j.tet.2008.01.125
Autor:
Ronald Palin, Hardy Sundaram, Philip S. Jones, David Vrolijk, Louise Evans, Mark A. Weston, David R. Barn, Grove Simon James Anthony, Helen Feilden, John K. Clark, J. Cottney, Marc Crockatt, Alasdair R.C. Smith, Grant Wishart, Paul Wren, Phillip M. Cowley, Richard Morphy, Frank Griekspoor, Richard R. Goodwin, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:589-593
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43590a4562dd3711ecd7e4e22da1580f
https://doi.org/10.1016/j.bmcl.2004.11.049
https://doi.org/10.1016/j.bmcl.2004.11.049
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2351-2354
The first solid-phase synthesis of zatebradine 1 and its analogues is reported. This has resulted in the preparation of compounds with increased ability to reduce the spontaneous beating of isolated guinea-pig atria in a concentration-dependent manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c525e8d7dcbf21a394c806372ab0b0ea
https://doi.org/10.1016/s0960-894x(01)00424-3
https://doi.org/10.1016/s0960-894x(01)00424-3