Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John K. Cini"'
Autor:
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 s
Externí odkaz:
https://doaj.org/article/9baead1eb8e549ccaed6f20a613f9c70
Autor:
John K. Cini, Susan Dexter, Darrel J. Rezac, Stephen J. McAndrew, Gael Hedou, Rich Brody, Rukiye-Nazan Eraslan, Richard T. Kenney, Pankaj Mohan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical trials involving therapeutic cytokines have encountered obstacles such as short pharm
Externí odkaz:
https://doaj.org/article/ec5b713791af4cd19df56d27a6cab5cc
Autor:
John K. Cini, Stephen J. McAndrew, Nick Evans, Lucie Janeckova, Maryam Ahmadi, Rukiye-Nazan Eraslan, Miglena G. Prabagar, Susan Dexter, Richard T. Kenney
Publikováno v:
Cancer Research. 82:4229-4229
Combination approaches using stimulatory cytokines, checkpoint inhibitors, chemotherapy and/or radiation therapy are known to improve overall survival of cancer patients. Recombinant interleukins (IL) have had limited clinical success due to short ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61350d47d043e158ac403c2a20145347
https://doi.org/10.1158/1538-7445.am2022-4229
https://doi.org/10.1158/1538-7445.am2022-4229
Autor:
John K. Cini, Susan Dexter, Stephen McAndrew, Robert Huebner, Hossein Borghaei, Darrel J. Rezac
Publikováno v:
Cancer Research. 81:1589-1589
Interleukin 12 (IL12) and other cytokines offer a potent and well characterized immunomodulatory therapy potential against multiple tumor types. Early efforts to advance recombinant human IL12 (rhIL12) were met with limited success in the clinic, due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6135f301215b666a8ce795ec3cfa9cc1
https://doi.org/10.1158/1538-7445.am2021-1589
https://doi.org/10.1158/1538-7445.am2021-1589
Autor:
John K. Cini, Athena D. Nagi
Publikováno v:
Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition ISBN: 9781841848204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8360021ac0ba58467bd7cc6040d1698f
https://doi.org/10.1081/e-ept4-120050200
https://doi.org/10.1081/e-ept4-120050200
Publikováno v:
Archives of Biochemistry and Biophysics. 253:205-213
Colony-stimulating factor 1 (CSF-1) was purified from the serum-free conditioned medium of a human pancreatic carcinoma cell line (MIA PaCa-2) by a combination of conventional chromatography and high-performance liquid chromatography. The purity of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d30cd9a91b25cd495052b660ac9eab
https://doi.org/10.1016/0003-9861(87)90653-9
https://doi.org/10.1016/0003-9861(87)90653-9
Publikováno v:
Archives of biochemistry and biophysics. 263(1)
Glucose-6-phosphate isomerase exists as multiple, catalytically active isozymes which can be resolved by polyacrylamide gel electrophoresis, isoelectric focusing, and ion-exchange chromatography. GPI from bovine heart was purified to homogeneity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123edff59c21ef420dd2f989267b1fdd
https://pubmed.ncbi.nlm.nih.gov/3369868
https://pubmed.ncbi.nlm.nih.gov/3369868
Publikováno v:
Molecular Biology of Aging ISBN: 9781489922205
The use of fibroblasts as in vitro models for the study of cellular and molecular changes which accompany aging was recognized almost twenty-five years ago. Fibroblasts exhibit a finite replicative capacity which is related to the age of the donor an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ea89f8f41ba310363e2db288ce1d25
https://doi.org/10.1007/978-1-4899-2218-2_27
https://doi.org/10.1007/978-1-4899-2218-2_27